Rapid identification of chemical compositions of three species of Schisandra chinensis by ultra‐high‐performance liquid chromatography quadrupole‐orbitrap‐mass spectrometry

Abstract

Schisandra chinensis is a traditional Chinese medicine, which has played an important role in the field of medicine and food. In this study, ultra‐high‐performance liquid chromatography quadrupole‐orbitrap‐mass spectrometry was used to rapidly classify and identify the chemical compositions. Note that 32, 28, and 30 kinds of compounds were successfully identified from northern Schisandra chinensis, vinegar‐processed Schisandra chinensis, and wine‐processed Schisandra chinensis, respectively. The cleavage patterns of various components including lignans, organic acids, flavonoids, and terpenoids were summarized, and the effects of different processing methods on Schisandra chinensis were analyzed through chemical composition. This method realized the rapid classification and identification of raw Schisandra chinensis and two different processed products, and provided references for improving the traditional processing methods, strengthening quality control, and ensuring safe clinical application.

Analytical strategies to identify multicomponent quality markers for commercial Hua‐ju‐hong using multidimensional chemical analysis

“…Notably, naringin was considered the only component marker for determining the quality of HJH in ChP, which would negate the unique medicinal and food value of HJH. LC‐MS and HPLC were two efficient methods for determining multi‐components in CMM [44, 45]. Using these two methods, it was found that other ingredients, such as bergapten, isoimperatorin, TCSC, and TCoH, whose content was far inferior to naringin but remarkably more in CGT than in CG, might play a synergistic role in regulating efficacy so that the therapeutic effect of CGT could be more optimized than that of CG.…”

A ternary correlation multi‐symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia

“…MS analysis of metabolites and constituents of TCM is a critical task. However, it generates a large amount of MS data that is difficult to analyze manually [25, 26]. Surprisingly, the emergence of comprehensive computational tools and metabolomic strategies has enabled efficient acceleration of MS data analysis.…”