Rapid identification and quantification of illicit drugs on nanodendritic surface-enhanced Raman scattering substrates

Dies, Hannah; Raveendran, Joshua; Escobedo, Carlos; Docoslis, Aristides

doi:10.1016/j.snb.2017.10.181

Cited by 81 publications

(71 citation statements)

References 17 publications

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“…Recently, we have published work involving a method for fabricating nanostructured silver surfaces via the electric field-driven assembly of silver nanoparticles from colloidal suspension [5]. These surfaces were applied for the sensitive detection of relevant chemical analytes [6,7].…”

Section: Introductionmentioning

confidence: 99%

Electrokinetically-Driven Assembly of Gold Colloids into Nanostructures for Surface-Enhanced Raman Scattering

et al. 2020

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Surface-enhanced Raman scattering (SERS) enables the highly sensitive detection of (bio)chemical analytes in fluid samples; however, its application requires nanostructured gold/silver substrates, which presents a significant technical challenge. Here, we develop and apply a novel method for producing gold nanostructures for SERS application via the alternating current (AC) electrokinetic assembly of gold nanoparticles into two intricate and frequency-dependent structures: (1) nanowires, and (2) branched “nanotrees”, that create extended sensing surfaces. We find that the growth of these nanostructures depends strongly on the parameters of the applied AC electric field (frequency and voltage) and ionic composition, specifically the electrical conductivity of the fluid. We demonstrate the sensing capabilities of these gold nanostructures via the chemical detection of rhodamine 6G, a Raman dye, and thiram, a toxic pesticide. Finally, we demonstrate how these SERS-active nanostructures can also be used as a concentration amplification device that can electrokinetically attract and specifically capture an analyte (here, streptavidin) onto the detection site.

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Section: Introductionmentioning

confidence: 99%

Electrokinetically-Driven Assembly of Gold Colloids into Nanostructures for Surface-Enhanced Raman Scattering

et al. 2020

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“…SERS finds reliable applications in medical diagnostics, therapeutic monitoring, pharmaceuticals, food safety analysis, and possibly, if integrated into a microcapsule, as ingestible sensors for therapeutic drug monitoring and health analysis. [9][10][11][12][13] In SERS, when a molecule is adsorbed onto nano-roughened noble metal surfaces such as silver and gold, Raman spectra will considerably be amplified.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of metal Nanoparticles for SERS-based Detections of illicit drugs in biological samples

Azimi¹

2020

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Surface-enhanced Raman scattering (SERS) has been widely used for the detection of illicit drugs due to its excellent chemical fingerprint information, high sensitivity by plasmon-enhanced excitation and scattering, and independence of aqueous solution impact. Even though it has been more than one decade since the first SERS was synthesized, extensive effort has recently been undertaken to improve hand-held Raman analyzer and make SERS a practical point-of-care (POC) device for the detection of illicit drugs in real samples. Lately, there has been a fast growth in improving methods for precise control over metal nanoparticle size and modification of their detection performance with functionalizing agents, which will dramatically enhance their application in various biomedical applications.In this study, a general view on the background of the SERS and several basic concepts and focuses are discussed. Then we put forward a summary of the progress in trace determination of illicit drugs using various functionalization methods for enhancing characteristics of the substrate toward a more selective detection of the analytes.

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“…4,5 Therefore, development of reliable, sensitive and selective methods for detection of trace amounts of cocaine is of paramount importance. To date, several analytical methods have been developed for determination of cocaine, including high performance liquid chromatography, 6,7 gas-chromatography-mass spectrometry, 8 ion mobility spectrometry, [9][10][11] surface-enhanced Raman scattering spectroscopy, 12,13 chemiluminescence, 14 uorescence, 15,16 colorimetry 17,18 and piezoelectric. 19 Although most of the mentioned techniques provide satisfactory sensitivities for cocaine detection, but development of simple, cost-effective and fast analytical methods for sensitive and selective detection of cocaine is still an open research area.…”

Section: Introductionmentioning

confidence: 99%

A nanoporous gold-based electrochemical aptasensor for sensitive detection of cocaine

2019

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The increasing application of aptamers in bioassays has triggered a lot of research interest for development of highly sensitive and selective sensing platforms. Herein, we report on the design of a sensitive cocaine biosensor by immobilizing the 5 0 -disulfide-functionalized end of an aptamer sequence on a nanoporous gold (NPG) electrode followed by the conjugation of its 3 0 -amino-functionalized end to 2,5dihydroxybenzoic acid (DHBA) as the redox probe. In the presence of cocaine, the aptamer undergoes a conformational change from an open unfolded state to a closed conformation, which reduces the distance between DHBA and the electrode surface, resulting in the enhanced electron-transfer efficiency.Using square wave voltammetric method and under the optimal conditions, the cocaine aptasensor presented two linear responses in the concentration ranges between 0.05-1 and 1-35 mM, with an excellent detection limit of 21 nM. The proposed aptasensor provides a simple and low-cost method for cocaine detection with good reproducibility and accuracy. Furthermore, it could be regarded as a general model to investigate the unique function of aptamer-functionalized nanostructured electrodes to stablish highly advanced electrochemical biosensors for various target analytes of diagnostic importance.

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Rapid identification and quantification of illicit drugs on nanodendritic surface-enhanced Raman scattering substrates

Cited by 81 publications

References 17 publications

Electrokinetically-Driven Assembly of Gold Colloids into Nanostructures for Surface-Enhanced Raman Scattering

Electrokinetically-Driven Assembly of Gold Colloids into Nanostructures for Surface-Enhanced Raman Scattering

Functionalization of metal Nanoparticles for SERS-based Detections of illicit drugs in biological samples

A nanoporous gold-based electrochemical aptasensor for sensitive detection of cocaine

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