Rapid<i>in vivo</i>screening system for anti-oxidant activity using bacterial redox sensor strains

Park, S. J.; Chung, Hae Young; Lee, J. H.

doi:10.1111/j.1365-2672.2009.04514.x

Cited by 10 publications

(2 citation statements)

References 33 publications

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“…First, these bacteria may maintain these pools as preemptive hedges against future insults (102). GB is a protectant against osmostress, temperature stress, and oxidative stress, and has a role in maintenance of intracellular pH (98,(108)(109)(110). Therefore, perhaps GB is stored in these bacteria to provide enhanced survival and recovery from unexpected insults that provide a survival benefit versus bacteria that do not have such storage systems.…”

Section: Gb Storage: Protection For the Future?mentioning

confidence: 99%

Homeostasis and Catabolism of Choline and Glycine Betaine: Lessons from Pseudomonas aeruginosa

Wargo

2013

Appl Environ Microbiol

155

121

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Most sequenced bacteria possess mechanisms to import choline and glycine betaine (GB) into the cytoplasm. The primary role of choline in bacteria appears to be as the precursor to GB, and GB is thought to primarily act as a potent osmoprotectant. Choline and GB may play accessory roles in shaping microbial communities, based on their limited availability and ability to enhance survival under stress conditions. Choline and GB enrichment near eukaryotes suggests a role in the chemical relationships between these two kingdoms, and some of these interactions have been experimentally demonstrated. While many bacteria can convert choline to GB for osmoprotection, a variety of soil-and water-dwelling bacteria have catabolic pathways for the multistep conversion of choline, via GB, to glycine and can thereby use choline and GB as sole sources of carbon and nitrogen. In these choline catabolizers, the GB intermediate represents a metabolic decision point to determine whether GB is catabolized or stored as an osmo-and stress protectant. This minireview focuses on this decision point in Pseudomonas aeruginosa, which aerobically catabolizes choline and can use GB as an osmoprotectant and a nutrient source. P. aeruginosa is an experimentally tractable and ecologically relevant model to study the regulatory pathways controlling choline and GB homeostasis in choline-catabolizing bacteria. The study of P. aeruginosa associations with eukaryotes and other bacteria also makes this a powerful model to study the impact of choline and GB, and their associated regulatory and catabolic pathways, on host-microbe and microbe-microbe relationships.

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Section: Gb Storage: Protection For the Future?mentioning

confidence: 99%

Homeostasis and Catabolism of Choline and Glycine Betaine: Lessons from Pseudomonas aeruginosa

Wargo

2013

Appl Environ Microbiol

155

121

View full text Add to dashboard Cite

show abstract

“…Contrary to these reported biological activities, it has also been shown that some flavonoids can be pro-oxidant to DNA at certain concentrations (Macgregor and Jurd, 1978;Johnson and Loo, 2000). Indeed, whereas flavonoids such as quercetin, rutin and kaempferol significantly reduced oxidative damage even at low concentrations, betaine, glycyrrhizic acid and baicalin required higher concentration for their antioxidant activities (Park et al, 2010). However, some flavonoids, such as procyanidin B4, catechin and gallic acid, could prevent oxidative damage to cellular DNA at low concentration but induce cellular DNA damage at a high concentration (Fan and Lou, 2004).…”

Section: Compoundmentioning

confidence: 77%