Rapid, High‐Resolution Magnetic Microscopy of Single Magnetic Microbeads

McCoey, Julia M.; Gille, Robert W. de; Nasr, Babak; Tetienne, J.‐P.; Hall, Liam T.; Simpson, David A.; Hollenberg, Lloyd C. L.

doi:10.1002/smll.201805159

Cited by 18 publications

(11 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relaxation may occur via the transverse and longitudinal relaxation channels characterized by their respective decay times T 2 and T 1 . However, we mainly focus on the latter one in this section, as the T 1 scheme (Figure c) is more frequently applied in bio-sensing. ,,− …”

Section: High-precision Bio-sensing At the Nanoscalementioning

confidence: 99%

Toward Quantitative Bio-sensing with Nitrogen–Vacancy Center in Diamond

et al. 2021

View full text Add to dashboard Cite

The long-dreamed-of capability of monitoring the molecular machinery in living systems has not been realized yet, mainly due to the technical limitations of current sensing technologies. However, recently emerging quantum sensors are showing great promise for molecular detection and imaging. One of such sensing qubits is the nitrogen−vacancy (NV) center, a photoluminescent impurity in a diamond lattice with unique roomtemperature optical and spin properties. This atomic-sized quantum emitter has the ability to quantitatively measure nanoscale electromagnetic fields via optical means at ambient conditions. Moreover, the unlimited photostability of NV centers, combined with the excellent diamond biocompatibility and the possibility of diamond nanoparticles internalization into the living cells, makes NV-based sensors one of the most promising and versatile platforms for various life-science applications. In this review, we will summarize the latest developments of NV-based quantum sensing with a focus on biomedical applications, including measurements of magnetic biomaterials, intracellular temperature, localized physiological species, action potentials, and electronic and nuclear spins. We will also outline the main unresolved challenges and provide future perspectives of many promising aspects of NV-based bio-sensing.

show abstract

Section: High-precision Bio-sensing At the Nanoscalementioning

confidence: 99%

Toward Quantitative Bio-sensing with Nitrogen–Vacancy Center in Diamond

et al. 2021

View full text Add to dashboard Cite

show abstract

“…These magnetic fluctuations can act as magnetic noise sources when brought sufficiently close (typically < 100 nm) to NV centers in diamond. By using the same widefield microscope and monitoring the spin relaxation rate (1/T1) of the NV centers across the full field of view (Materials and Methods), we can detect and map the fluctuating magnetic fields signals directly, in a technique termed quantum relaxation microscopy (QRM) (23)(24)(25). For completeness we applied QRM to image each of the iron cuticulosomes identified in Figs.…”

Section: Ground Statementioning

confidence: 99%

Quantum magnetic imaging of iron organelles within the pigeon cochlea

Gille

McCoey

Hall

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

The ability of pigeons to sense geomagnetic fields has been conclusively established despite a notable lack of determination of the underlying biophysical mechanisms. Quasi-spherical iron organelles previously termed “cuticulosomes” in the cochlea of pigeons have potential relevance to magnetoreception due to their location and iron composition; however, data regarding the magnetic susceptibility of these structures are currently limited. Here quantum magnetic imaging techniques are applied to characterize the magnetic properties of individual iron cuticulosomes in situ. The stray magnetic fields emanating from cuticulosomes are mapped and compared to a detailed analytical model to provide an estimate of the magnetic susceptibility of the individual particles. The images reveal the presence of superparamagnetic and ferrimagnetic domains within individual cuticulosomes and magnetic susceptibilities within the range 0.029 to 0.22. These results provide insights into the elusive physiological roles of cuticulosomes. The susceptibilities measured are not consistent with a torque-based model of magnetoreception, placing iron storage and stereocilia stabilization as the two leading putative cuticulosome functions. This work establishes quantum magnetic imaging as an important tool to complement the existing array of techniques used to screen for potential magnetic particle–based magnetoreceptor candidates.

show abstract

“…1(f)]. The latter topic has seen widefield NV microscopes used to investigate a variety of artificial magnetic structures from nano-and micro-particles [50][51][52] to thin-film structures, 21,30,[53][54][55][56] as well as to character-ize spin excitations in these structures 57 and phase transitions at high pressure. [58][59][60] Finally, widefield NV microscopes have been used to probe electric currents via their associated Ørsted magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Widefield quantum microscopy with nitrogen-vacancy centers in diamond: strengths, limitations, and prospects

Scholten,

Healey,

Robertson

et al. 2021

Preprint

View full text Add to dashboard Cite

A dense layer of nitrogen-vacancy (NV) centers near the surface of a diamond can be interrogated in a widefield optical microscope to produce spatially resolved maps of local quantities such as magnetic field, electric field and lattice strain, providing potentially valuable information about a sample or device placed in proximity. Since the first experimental realization of such a widefield NV microscope in 2010, the technology has seen rapid development and demonstration of applications in various areas across condensed matter physics, geoscience and biology. This Perspective analyzes the strengths and shortcomings of widefield NV microscopy in order to identify the most promising applications and guide future development. We begin with a brief review of quantum sensing with ensembles of NV centers, and the experimental implementation of widefield NV microscopy. We then compare this technology to alternative microscopy techniques commonly employed to probe magnetic materials and charge flow distributions. Current limitations in spatial resolution, measurement accuracy, magnetic sensitivity, operating conditions and ease of use, are discussed. Finally, we identify the technological advances that solve the aforementioned limitations, and argue that their implementation would result in a practical, accessible, high-throughput widefield NV microscope.

show abstract

Rapid, High‐Resolution Magnetic Microscopy of Single Magnetic Microbeads

Cited by 18 publications

References 48 publications

Toward Quantitative Bio-sensing with Nitrogen–Vacancy Center in Diamond

Toward Quantitative Bio-sensing with Nitrogen–Vacancy Center in Diamond

Quantum magnetic imaging of iron organelles within the pigeon cochlea

Widefield quantum microscopy with nitrogen-vacancy centers in diamond: strengths, limitations, and prospects

Contact Info

Product

Resources

About