Rapid-Growing Juvenile Xanthogranuloma on the Scalp in 18-Month-Old Girl

Abstract

Juvenile xanthogranuloma (JXG) is an uncommon histiocytic cutaneous lesion. An 18-month-old girl visited our clinic due to rapid growing orange-yellowish lesion on scalp. Enlarging time from 1 mm to 12 mm was just 8 weeks. We excised the tumor and adjacent normal tissue. Histopathological study showed numerous eosinophils and Touton giant cells within the lesion. Immunohistochemical study revealed positive immunoreactivity for CD68 in most areas. No recurrence was seen during 12 months after resection. We report a case with rapidly growing JXG on scalp with peculiar histopathologic findings.

Successful Treatment of Non-Langerhans Cell Histiocytosis With Topical Rapamycin in Two Pediatric Cases

“… 11 Certain treatment can be considered for rapidly growing skin-limited cases that raise aesthetic concerns. 12 However, this therapeutic approach may not always be consensual and should be evaluated on a case-by-case basis. Therapeutic options may include low-dose radiotherapy, intralesional steroid injections, cryotherapy, CO 2 laser treatment, and surgical excision.…”

Congenital Giant Juvenile Xanthogranuloma in a 3-Month-Old Boy

“…Spontaneous regression was unlikely, and in view of the rapid growth, we were concerned that waiting would lead to cosmetic and functional problems. 1 Therefore, we performed an extended excision; the tumor did not recur after resection.…”

“…JXG, the most common non-Langerhans cell histiocytosis, is a benign self-limited histiocytic proliferative disorder characterized by small yellow-red nodules or papules. 1 The etiopathology is unknown. 2 The average age of onset is 2 years.…”

“…5 The most common affected areas are the head, neck, and trunk, followed by the proximal extremities. 1 Histopathologic examination is essential to confirm the diagnosis.…”