Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy

Berger, Carole L.; Hoffmann, Kristin Elizabeth; Vasquez, Juan C.; Mane, Shrikant; Lewis, Julia M.; Filler, Renata; Ai, Lin; Zhao, Hongyu; Durazzo, Tyler S.; Baird, Abigail H.; Lin, Woei; Foss, Francine M.; Christensen, Inger; Girardi, Michael; Tigelaar, Robert E.; Edelson, Richard L.

doi:10.1182/blood-2009-11-256040

Cited by 80 publications

(66 citation statements)

References 36 publications

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“…LAMP3, a marker specific to DC differentiation [14], was upregulated four-fold (398%). CD80, a costimulatory molecule known to be upregulated upon APC activation [15], was found upregulated two-fold (220%) in monocytes exposed to high levels of platelets. CCR7, a chemokine receptor known to play a role in DC migration to lymphoid organs, was upregulated nearly four-fold (376%).…”

Section: Resultsmentioning

confidence: 99%

Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling

Durazzo

Tigelaar

Filler

et al. 2014

Transfusion and Apheresis Science

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Extracorporeal Photochemotherapy (ECP) is a widely used therapy for cutaneous T cell lymphoma (CTCL). Although the mechanism of clinical action of ECP is not precisely established, previous studies have shown evidence of induction of dendritic cells (DC). Here we show that, under flow conditions similar to those in post-capillary venues, ECP promotes platelet immobilization and activation, initiating stepwise receptor-ligand interactions with monocytes, which then differentiate into DC. These findings clarify how ECP directly stimulates DC maturation; suggest a new clinically applicable approach to the obtainment of DC; and identify a novel mechanism that may reflect physiological induction of DC.

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Section: Resultsmentioning

confidence: 99%

Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling

Durazzo

Tigelaar

Filler

et al. 2014

Transfusion and Apheresis Science

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“…Different groups have reported that ECP promoted the differentiation and partial maturation of DC based on surface costimulatory molecule expression, migratory activity, and Ag presentation assays (13,37,38). Of interest, Holtick et al (37) reported an increased immunostimulatory and migratory capacity of ECP-treated monocyte-derived DC.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have reported that ECP can expand the number of regulatory T cells (Tregs), providing a rationale to understand the immunoregulatory efficacy of ECP for the treatment of graft-versus-host disease and solid organ transplant rejection (10)(11)(12). In contrast, only few publications have revealed the immunostimulatory activity of ECP, which suggests that ECP promotes monocyte differentiation into dendritic cells (DC) and elevation of TNF-a production (13)(14)(15).…”

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confidence: 99%

Extracorporeal Photopheresis Promotes IL-1β Production

Yakut

Jakobs

Peric

et al. 2015

The Journal of Immunology

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Extracorporeal photopheresis (ECP) is a widely used clinical cell-based therapy exhibiting efficacy in heterogenous immune-mediated diseases such as cutaneous T cell lymphoma, graft-versus-host disease, and organ allograft rejection. Despite its documented efficacy in cancer immunotherapy, little is known regarding the induction of immunostimulatory mediators by ECP. In this article, we show that ECP promotes marked release of the prototypic immunostimulatory cytokine IL-1β. ECP primes IL-1β production and activates IL-1β maturation and release in the context of caspase-1 activation in monocytes and myeloid dendritic cells. Of interest, IL-1β maturation by ECP was fully intact in murine cells deficient in caspase-1, suggesting the predominance of an inflammasome-independent pathway for ECP-dependent IL-1β maturation. Clinically, patient analysis revealed significantly increased IL-1β production in stimulated leukapheresis concentrates and peripheral blood samples after ECP. Collectively, these results provide evidence for promotion of IL-1β production by ECP and offer new insight into the immunostimulatory capacity of ECP.

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“…Psoralen covalently binds and crosslinks DNA following UVA exposure, leading to the induction of apoptosis in the majority of treated lymphocytes by multiple mechanisms involving bcl-2 family members, disruption of the mitochondrial membrane potential and extrinsic cell death pathways [303][304][305]. In contrast, ECP leads to monocyte activation, including significant changes in gene expression [306], and dendritic cell differentiation, which is thought to culminate in enhanced antigen presentation and the initiation of a host immune response [307]. In hopes of prolonging the exposure time between monocyte-derived dendritic cells and malignant lymphocytes undergoing apoptosis, investigators have developed a modified ECP protocol (i.e., ''transimmunization'') whereby blood products are incubated overnight following UVA irradiation and before patient infusion [308].…”

Section: Extracorporeal Photophoresismentioning

confidence: 99%

Cutaneous T‐cell lymphoma: 2011 update on diagnosis, risk‐stratification, and management

Wilcox

2011

American J Hematol

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Disease overview: Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis fungoides (MF) or Sézary syndrome (SS).Diagnosis: The diagnosis of MF or SS requires the integration of clinical and histopathologic data.Risk‐adapted therapy: Tumor, node, metastasis, and blood (TNMB) staging remains the most important prognostic factor in MF/SS and forms the basis for a “risk‐adapted,” multidisciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin‐directed therapies is preferred, as both disease‐specific and overall survival for these patients is favorable. In contrast, patients with advanced‐stage disease with significant nodal, visceral, or blood involvement are generally approached with biologic‐response modifiers, denileukin diftitox, and histone deacetylase inhibitors before escalating therapy to include systemic, single‐agent chemotherapy. Multiagent chemotherapy may be used for those patients with extensive visceral involvement requiring rapid disease control. In highly‐selected patients with disease refractory to standard treatments, allogeneic stem‐cell transplantation may be considered. Am. J. Hematol., 2011. © 2011 Wiley‐Liss, Inc.

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Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy

Cited by 80 publications

References 36 publications

Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling

Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling

Extracorporeal Photopheresis Promotes IL-1β Production

Cutaneous T‐cell lymphoma: 2011 update on diagnosis, risk‐stratification, and management

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