Rapid Gastric Emptying Is More Common than Gastroparesis in Patients With Autonomic Dysfunction

Lawal, Adeyemi; Barboi, Alexandru; Krasnow, A Z; Hellman, Robert S.; Jaradeh, Safwan; Massey, Benson T.

doi:10.1111/j.1572-0241.2006.00946.x

Cited by 56 publications

(48 citation statements)

References 31 publications

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“…Rapid emptying has been recently observed as an accompanying factor in adult patients with cyclic vomiting syndrome (25,26). In one study, rapid GE was more common than delayed GE in symptomatic patients with autonomic dysfunction (27).…”

Section: Rapid Gementioning

confidence: 96%

Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine

Abell

Camilleri

Donohoe

et al. 2008

Journal of Nuclear Medicine Technology

474

527

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This consensus statement from the members of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine recommends a standardized method for measuring gastric emptying (GE) by scintigraphy. A low-fat, eggwhite meal with imaging at 0, 1, 2, and 4 h after meal ingestion, as described by a published multicenter protocol, provides standardized information about normal and delayed GE. Adoption of this standardized protocol will resolve the lack of uniformity of testing, add reliability and credibility to the results, and improve the clinical utility of the GE test.

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Section: Rapid Gementioning

confidence: 96%

Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine

Abell

Camilleri

Donohoe

et al. 2008

Journal of Nuclear Medicine Technology

474

527

View full text Add to dashboard Cite

show abstract

“…Interpreting why rapid gastric emptying is present in the vomiting-free period has led to speculation that there is an underlying autonomic dysfunction [7]. This is consistent with data that rapid gastric emptying is reported more commonly than delayed gastric emptying in symptomatic patients with autonomic dysfunction [16].…”

Section: Discussionmentioning

confidence: 74%

Dumping Syndrome: Establishing Criteria for Diagnosis and Identifying New Etiologies

2009

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“…Mechanisms for GLS may include rapid movement of food to the small bowel resulting in small bowel distention and accompanied nausea, pain, and diarrhea, ie, similar symptoms to that of gastroparesis. 16,17 Other mechanisms may relate to proximal gastric activity, which might be better demonstrated by liquid gastric emptying, something not evaluated in this study. Indeed, patients with normal gastric emptying may be more similar to RGE than delayed gastroparesis as a mechanism for their symptomatology.…”

Section: Discussionmentioning

confidence: 90%

“…19 Our study supports prior studies reporting the poor correlation between clinical symptomatology and the diagnosis of gastroparesis. 17,18 This study did not look at response of tGES to pain, except as part of a larger symptoms spectrum. However, a recent report did examine pain, in relation to neuropathic changes in the GI tract, and found that some patients with abdominal pain do respond well to tGES.…”

Section: Discussionmentioning

confidence: 99%

Temporary Endoscopic Stimulation in Gastroparesis-like Syndrome

Singh

McCrary

Kedar

et al. 2015

J Neurogastroenterol Motil

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Background/AimsGastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implanted consecutive patients with symptoms of gastroparesis with temporary gastric electrical stimulation and observed changes in gastric scintigraphy and total symptom score. MethodsFive hundred and fifty-one patients suffering from symptoms of gastroparesis (nausea, vomiting, bloating/distension, anorexia/early satiety, and abdominal pain) with negative endoscopy underwent gastric scintigraphy with analysis of 1) solid radionuclide gastric emptying at 1, 2, and 4 hours (% remaining); 2) area under the gastric emptying curve (AUC) at 1, 2, and 4 hours; and 3) total gastric emptying test (GET) (the sum of 1, 2, and 4 hour values). Patients were stratified into: delayed gastric emptying, normal gastric emptying, and rapid gastric emptying (Appendix). Of the 551 patients in the larger cohort, 379 had implantation of temporary gastric electrical stimulation (tGES). Gastrointestinal symptoms and gastric emptying were compared pre and post tGES implantation. ResultsAfter tGES, 2 hour gastric retention decreased (P ＜ 0.01) for the delayed patients, and increased (P ＜ 0.001) for normal and rapid patients. These changes were accompanied by improvements (P ＜ 0.001) in vomiting, nausea, and total symptom scores in all 3 subgroups.

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Rapid Gastric Emptying Is More Common than Gastroparesis in Patients With Autonomic Dysfunction

Cited by 56 publications

References 31 publications

Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine

Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine

Dumping Syndrome: Establishing Criteria for Diagnosis and Identifying New Etiologies

Temporary Endoscopic Stimulation in Gastroparesis-like Syndrome

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