Rapid Fire Abstract session: new insights in cardiomyopthies434The role of 4D echocardiography and cardiac biomarkers for early detection of chemotherapy induced cardiotoxicity in nonHodgkin lymphoma patients435Identification of proto-oncogenes and genes responsible for myocardial fibrosis and diastolic dysfunction after anticancer treatment under experimental conditions436Wild type transthyretin cardiac amyloidosis: clinical characteristics, echocardiographic findings, and predictors of outcome437A novel

Mihalcea, D.; Bergler‐Klein, Jutta; Grogan, Martha; Pagourelias, E; Faber, Lothar; Ciampi, Quirino; Debonnaire, P.J.M.R.; Saberniak, Jørg; Florescu, Maria; Vladareanu, AM; Mihaila, S.; Vinereanu, Dragoş; Spannbauer, Andreas; Zlabinger, Katrin; Macejovska, Dominika; Maurer, G.; Gyöngyösi, Mariann; Scott, C G; Lin, Grace; Klarich, Kyle W.; Miller, Wayne L.; Dispenzieri, A.; Mirea, OC; Duchenne, J; Vovas, Georgios; Aelst, Lucas Van; Claus, Piet; Cleemput, Johan Van; Delforge, Michel; Bogaert, J.; Voigt, J U; Burghardt, Amelie; Seggewiß, Hubert; Buuren, Frank van; Horstkotte, Dieter; Olivotto, Iacopo; Gardini, Chiara; Monserrat, L; Peteiro, Jesús; Lopes, Lílian Maria; Cotrim, Carlos; Losi, Ma; Lazzeroni, DE; Joyce, Emer; Brink, OVW Van Den; Bax, J. J.; Delgado, V.; Marsan, N Ajmone; Leren, IS; Haland, TF; Hopp, Einar; Edvardsen, Thor; Haugaa, Kristina H.

doi:10.1093/ehjci/jev254

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“…The mean age at diagnosis ranged from 74.0 to 93.8 years. Few studies used autopsies (n = 5) to identify eligible patients [20,46,61,62,64]. Seventeen studies used endomyocardial biopsy to diagnose at least one patient [19, 20, 22, 42, 43, 46, 47, 50-53, 55, 56, 60-62, 64], nine studies used either extracardiac biopsy or other diagnostic methods (e.g., scintigraphy) [41,44,45,48,54,[57][58][59]63] and two studies did not report any diagnostic methods [40,49].…”

Section: Included Studiesmentioning

confidence: 99%

Estimating the Gender Distribution of Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy: A Systematic Review and Meta-Analysis

Kroi¹,

Fischer

Gezin³

et al. 2020

Cardiol Ther

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Introduction This study investigates the gender distribution in patients diagnosed with wild-type transthyretin amyloidosis cardiomyopathy (ATTRwt). Methods A systematic review and meta-analysis of the male proportion in diagnosed ATTRwt patients were conducted. To avoid overlapping population, pooled estimates in the primary analysis were based on all unique studies. In secondary analyses, we considered predefined subsets of studies based on study sample size, recruitment years, geography, study design, age at diagnosis, and method of diagnosis. Additional meta-regression analyses were tested for potential determinants of gender distribution. Results Twenty-eight unique studies (2542 patients) were included in the meta-analysis. Male proportion in patients with ATTRwt was 86.9% (95% confidence interval 81.5–91.6%). Studies, including patients older than 80 years at diagnosis, had a 29.1% ( p value < 0.001) lower male proportion compared to studies, including younger patients. After adjusting for age, studies using autopsy as a method of diagnosis had a 21.1% ( p value 0.002) lower male proportion compared to other studies. Conclusions Studies conducted to date suggest ATTRwt disproportionally affects males. The proportion of males was significantly impacted by the age at diagnosis and method diagnosis, which may suggest important gender-based differences in the clinical manifestation and diagnostic challenges of ATTRwt in females that warrant future research. Electronic supplementary material The online version of this article (10.1007/s40119-020-00205-3) contains supplementary material, which is available to authorized users.

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