Rapid feasibility assessment for the use of wiped-film evaporation in the purification of thermally labile products

Fonseca, Juan D.; Suaza, Andrea; Cortes, Ricardo F.; Gil, Iván D.; Rodríguez, Gerardo; Orjuela, Álvaro

doi:10.1016/j.cherd.2019.04.002

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…The poor purity of MP in some experiments can be associated to the presence of remaining solvent, which could not be removed during distillation due to the high boiling point. In this case, low volatile solvents could be better removed using enhanced evaporation techniques such as falling or wiped film evaporation under vacuum conditions (Fonseca et al, ). Other impurities in MP could correspond to SE dissolved in the extraction solvent, which agrees with the theoretical selectivity reported in Table (

\frac{italicRE D_{i, italicMP}}{italicRE D_{i, mono} + italicRE D_{i, italicdi}}

).…”

Section: Resultsmentioning

confidence: 99%

A Quantitative Multi‐Criteria Solvent Selection Method for Extraction Processes: Case Study—Downstream Purification of Sucrose‐Based Surfactants

Chavarrio

Gutiérrez

Orjuela

2020

J Surfact & Detergents

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This work developed a novel method for the identification and selection of green solvents for extraction processes. The methodology was experimentally validated in the downstream separation of sucrose-based surfactants obtained from a solvent-free transesterification of sucrose and methyl palmitate (MP). First, a preliminary solvent screening was carried out taking into account environmental consciousness, extraction effectiveness, and predicted operating costs, combining both theoretical and empirical inputs. Potential solvents were first selected from a green solvents list used at the pharmaceutical industry, and the affinity with reactants was assessed based on the Hansen solubility parameters. Solvent suitability was ranked according to a novel objective function that incorporated the heat of vaporization, normal boiling point, cost, and availability. In the case of study, ethyl acetate was identified as the most promising solvent for MP extraction. This and other solvents were experimentally evaluated to validate the selection method and to assess their extraction performance. According to different effectiveness criteria, ethyl acetate was confirmed as the preferable extraction solvent. Finally, MP extraction from reaction media was optimized, varying temperature, number of stages, and solvent loading. Purified sucrose esters were subjected to bleaching obtaining a product under market specifications.

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\frac{italicRE D_{i, italicMP}}{italicRE D_{i, mono} + italicRE D_{i, italicdi}}

).…”

Section: Resultsmentioning

confidence: 99%

A Quantitative Multi‐Criteria Solvent Selection Method for Extraction Processes: Case Study—Downstream Purification of Sucrose‐Based Surfactants

Chavarrio

Gutiérrez

Orjuela

2020

J Surfact & Detergents

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“…Thin film evaporation (TFE), or wiped film evaporation [24][25][26][27][28], is a distillation process where the solution flows through cylindrical equipment and is wiped around the internal wall by blades or rollers to form a thin film. A jacket is used to heat the walls of the equipment and the process takes place at reduced pressure, causing water to evaporate from the oligonucleotide solution as it travels through the evaporator.…”

Section: Distillation Proceduresmentioning

confidence: 99%

Technical Considerations for Use of Oligonucleotide Solution API

Müslehiddinoğlu

Simler

Hill

et al. 2020

Nucleic Acid Therapeutics

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The most common approach for the manufacture of oligonucleotides includes isolation of the active pharmaceutical ingredient (API) via lyophilization to provide a solid product, which is then dissolved to provide an aqueous formulation. It is well known from the development and manufacture of large molecules (“biologics”) that API production does not always require isolation of solid API before drug product formulation, and this article provides technical considerations for the analogous use of oligonucleotide API in solution. The primary factor considered is solution stability, and additional factors such as viscosity, concentration, end-to-end manufacturing, microbiological control, packaging, and storage are also discussed. The technical considerations discussed in this article will aid the careful evaluation of the relative advantages and disadvantages of solution versus powder API for a given oligonucleotide drug substance.

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Tributyl citrate production via reactive distillation: Model reconciliation, optimization, scale up and sustainability indicators

Santaella

Gutiérrez

Orjuela

2022

Chemical Engineering Journal

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Rapid feasibility assessment for the use of wiped-film evaporation in the purification of thermally labile products

Cited by 4 publications

References 28 publications

A Quantitative Multi‐Criteria Solvent Selection Method for Extraction Processes: Case Study—Downstream Purification of Sucrose‐Based Surfactants

A Quantitative Multi‐Criteria Solvent Selection Method for Extraction Processes: Case Study—Downstream Purification of Sucrose‐Based Surfactants

Technical Considerations for Use of Oligonucleotide Solution API

Tributyl citrate production via reactive distillation: Model reconciliation, optimization, scale up and sustainability indicators

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