Rapid fabrication of three-dimensional flower-like gold microstructures on flexible substrate for SERS applications

Lu, Sichen; You, Tingting; Gao, Yukun; Yang, Nan; Zhang, Chenmeng; Yin, Ping

doi:10.1016/j.saa.2019.01.018

Cited by 24 publications

(12 citation statements)

References 34 publications

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“…Guo and Wang 22 reported similar types of gold structures synthesized by the electrochemical method. Several other studies also showed SB-D alike gold particles, [23][24][25] synthesized by modern techniques. On the other hand, the uniform coral shaped microstructure of SB-C also raised a similar suspicion, as this type of shape is unlikely to be observed in Bhasma samples known to be manufactured by traditional methods.…”

Section: Discussionmentioning

confidence: 85%

Physicochemical Variation in Nanogold-Based Ayurved Medicine Suvarna Bhasma Produced by Various Manufacturers Lead to Different In Vivo Bioaccumulation Profiles

Biswas

Chawda²,

Thakur³

et al. 2021

J Evid Based Complementary Altern Med

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Suvarna Bhasma (SB) is a gold particle-based medicine that is used in Ayurved to treat tuberculosis, arthritis and nervous diseases. Traditionally, the Ayurved preparation processes of SB do exist, but they are all long, tedious and involve several steps. Due to this, there is a possibility of bypassing the necessary Ayurved processes or non-adherence to all steps or use of synthetic gold particles. Our aim is to characterize 5 commercial SB preparations from 5 different manufacturers. A comparative physicochemical, pharmacokinetic (PK) and bioaccumulation study was carried out on all the 5 SB preparations. The general appearance such as color and texture of these 5 samples were different from each other. The size, shape and gold concentration (from 32-98 wt%) varied among all the 5 SBs. The accumulation of ionic gold in zebrafish and gold concentration profiles in rat blood were found to be significantly different for all the 5 SBs. Non-compartmental PK model obtained from the concentration-time profile showed significant differences in various PK parameters such as peak concentration (Cmax), half-life (t1/2) and terminal elimination slope (λz) for all the 5 SB preparations. SB-B showed the highest Cmax (8.55 μg/L), whereas SB-D showed the lowest Cmax (4.66 μg/L). The dissolution of ionic gold from SBs in zebrafish tissue after the oral dose had a 5.5-fold difference between the highest and lowest ionic gold concentrations. All the 5 samples showed distinct physicochemical and biological properties. Based on characteristic microscopic morphology, it was found that 2 preparations among them were suspected of being manufactured by non-adherence to the mentioned Ayurved references.

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Section: Discussionmentioning

confidence: 85%

Physicochemical Variation in Nanogold-Based Ayurved Medicine Suvarna Bhasma Produced by Various Manufacturers Lead to Different In Vivo Bioaccumulation Profiles

Biswas

Chawda²,

Thakur³

et al. 2021

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

show abstract

“…Besides using surface patterns to generate enhanced EM fields, the assembly of Au or Ag nanostructures, such as nanospheres, 27,28 nanorods, 29–31 nanowires, 32 nanotriangles, 33 nanotubes 34,35 and nanostars, 36–39 could also be adopted to improve the EM fields and be fabricated as SERS substrates. These nanoparticles could be synthesized via relatively simpler chemical methods, 28,40–44 compared to the sophisticated physical methods mentioned above.…”

Section: Introductionmentioning

confidence: 99%

Facile and robust fabrication of hierarchical Au nanorods/Ag nanowire SERS substrates for the sensitive detection of dyes and pesticides

et al. 2022

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“…However, these methods involved the use of either complex operations with precise instrumentation or the rinsing residual oil process by using organic reagents. Because of the potential pollution and burden from oil and organic reagents, it may cause the interference of SERS detection such as overlapping peak disturbance, 26 high background signal, 27 fading the SERS performance of microgels, 28 and so on. 23 The agglomeration of nanoparticles was loaded in these preparing microgels and provided the "hotspot" in the SERS analysis, but the degree of the agglomeration of nanoparticles may affect the reproducibility of detection.…”

Section: ■ Introductionmentioning

confidence: 99%

Oil-Free Gold Nanobipyramid@Ag Microgels as a Functional SERS Substrate for Direct Detection of Small Molecules in a Complex Sample Matrix

et al. 2021

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Surface-enhanced Raman scattering (SERS) is a supersensitive analysis technology based on the target molecular fingerprint information. The enhancement of local electromagnetic field of the SERS substrate would increase the target molecules' Raman intensity which adsorb on the surface of nanoparticles. However, the existing adhesive macromolecules in the complex mixed sample would interfere with the adsorption of small target molecules, and it weakens the Raman intensity of target molecules. Microgels are one of the potential materials to suppress the interference of adhesive macromolecules and to avoid the complex pretreatments. However, most of the current microgel synthesis methods involve complex operations with precise instrumentation or the interference of oil and organic reagents. In this work, a simple and oil-free method was proposed to synthesize the gold nanobipyramid (Au NBP) @Ag@hyaluronic acid microgel via the condensation reaction of carboxyl and amino groups. As a proof-of-concept demonstration for small-molecule detection, the rhodamine 6G (R6G) molecules were allowed to enter inside the microgel through the meshes and adsorb on the surface of Au NBP@Ag nanoparticles within 30 min, while the macromolecule (bovine serum albumin in this case) was retained outside the microgel in the meantime. In addition, under the combined action of lightning rod effect of Au NBP and surface plasmon resonance effect of silver render the microgels with high SERS activity. The synthetic Au NBP@Ag@hyaluronic acid microgels were applied to detect 6-thioguanine in the human serum without any pretreatment process, and it showed a high signal enhancement and stable SERS signal, which can satisfy the requirement of clinical diagnosis. These results show that the proposed microgels have potential applications in the field of point-of-care testing.

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Rapid fabrication of three-dimensional flower-like gold microstructures on flexible substrate for SERS applications

Cited by 24 publications

References 34 publications

Physicochemical Variation in Nanogold-Based Ayurved Medicine Suvarna Bhasma Produced by Various Manufacturers Lead to Different In Vivo Bioaccumulation Profiles

Physicochemical Variation in Nanogold-Based Ayurved Medicine Suvarna Bhasma Produced by Various Manufacturers Lead to Different In Vivo Bioaccumulation Profiles

Facile and robust fabrication of hierarchical Au nanorods/Ag nanowire SERS substrates for the sensitive detection of dyes and pesticides

Oil-Free Gold Nanobipyramid@Ag Microgels as a Functional SERS Substrate for Direct Detection of Small Molecules in a Complex Sample Matrix

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