Rapid Fabrication of Self‐Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body

Li, Sixiang; Wang, Le; Zheng, Wenfu; Yang, Guang; Jiang, Xingyu

doi:10.1002/adfm.202002370

Cited by 172 publications

(129 citation statements)

References 92 publications

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“…The endowment of an electrically conductive property to the hydrogel pattern is critical for applying neural or myogenic cells. Some researchers combined soft materials and electrically conductive property for stretchable bioelectronics [ 6 , 7 , 8 ], cardiac tissue engineering [ 9 ], and wound healing [ 10 ]. Nevertheless, few successful electrically conductive hydrogel micropatterns were synchronized with cell patterning because combining the hydrogel patterning with an electrically conductive material is challenging.…”

Section: Introductionmentioning

confidence: 99%

Electrically Conductive Micropatterned Polyaniline-Poly(ethylene glycol) Composite Hydrogel

et al. 2021

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Hydrogel substrate-based micropatterns can be adjusted using the pattern shape and size, affecting cell behaviors such as proliferation and differentiation under various cellular environment parameters. An electrically conductive hydrogel pattern system mimics the native muscle tissue environment. In this study, we incorporated polyaniline (PANi) in a poly(ethylene glycol) (PEG) hydrogel matrix through UV-induced photolithography with photomasks, and electrically conductive hydrogel micropatterns were generated within a few seconds. The electrical conductance of the PANi/PEG hydrogel was 30.5 ± 0.5 mS/cm. C2C12 myoblasts were cultured on the resulting substrate, and the cells adhered selectively to the PANi/PEG hydrogel regions. Myogenic differentiation of the C2C12 cells was induced, and the alignment of myotubes was consistent with the arrangement of the line pattern. The expression of myosin heavy chain on the line pattern showed potential as a substrate for myogenic cell functionalization.

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Section: Introductionmentioning

confidence: 99%

Electrically Conductive Micropatterned Polyaniline-Poly(ethylene glycol) Composite Hydrogel

et al. 2021

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“…In the last decades, research on conductive self-healing hydrogels has increased considerably [ 77 , 78 , 79 , 80 , 81 ]. The interest in this family of polymeric materials lies in their versatility and their potential uses in a wide variety of applications such as electronic skin, wound healing, human motion sensors, self-repairing circuits, soft robots, biomimetic prostheses and health monitoring systems [ 82 ].…”

Section: Polymeric Materials With Antibacterial Activitymentioning

confidence: 99%

Polymeric Materials with Antibacterial Activity: A Review

Olmos

González‐Benito

2021

Polymers

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Infections caused by bacteria are one of the main causes of mortality in hospitals all over the world. Bacteria can grow on many different surfaces and when this occurs, and bacteria colonize a surface, biofilms are formed. In this context, one of the main concerns is biofilm formation on medical devices such as urinary catheters, cardiac valves, pacemakers or prothesis. The development of bacteria also occurs on materials used for food packaging, wearable electronics or the textile industry. In all these applications polymeric materials are usually present. Research and development of polymer-based antibacterial materials is crucial to avoid the proliferation of bacteria. In this paper, we present a review about polymeric materials with antibacterial materials. The main strategies to produce materials with antibacterial properties are presented, for instance, the incorporation of inorganic particles, micro or nanostructuration of the surfaces and antifouling strategies are considered. The antibacterial mechanism exerted in each case is discussed. Methods of materials preparation are examined, presenting the main advantages or disadvantages of each one based on their potential uses. Finally, a review of the main characterization techniques and methods used to study polymer based antibacterial materials is carried out, including the use of single force cell spectroscopy, contact angle measurements and surface roughness to evaluate the role of the physicochemical properties and the micro or nanostructure in antibacterial behavior of the materials.

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“…[169] Their results showed that the hydrogel dressings upregulated the expression of CD31 growth factor to significantly promote angiogenesis and enhance the thickness of granulation tissue and favor the collagen deposition, which could accelerate wound closure in a mouse wound model with full thickness. In view of the fact that conductive materials can promote wound healing, [170] this group prepared another adhesive, antioxidant, conductive antibacterial hydrogel dressing by using the oxidative coupling of catechol groups with H 2 O 2 / HRP catalytic system based on dopamine-grafted gelatin (GT-DA) and PDA-coated CNT (CNT-PDA) ( Figure 8B). [171]…”

Section: Carbon-based Photothermal Hydrogelsmentioning

confidence: 99%

Antibacterial Hybrid Hydrogels

Cao

Luo

et al. 2020

Macromolecular Bioscience

122

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Bacterial infectious diseases and bacterial‐infected environments have been threatening the health of human beings all over the world. In view of the increased bacteria resistance caused by overuse or improper use of antibiotics, antibacterial biomaterials are developed as the substitutes for antibiotics in some cases. Among them, antibacterial hydrogels are attracting more and more attention due to easy preparation process and diversity of structures by changing their chemical cross‐linkers via covalent bonds or noncovalent physical interactions, which can endow them with various specific functions such as high toughness and stretchability, injectability, self‐healing, tissue adhesiveness and rapid hemostasis, easy loading and controlled drug release, superior biocompatibility and antioxidation as well as good conductivity. In this review, the recent progress of antibacterial hydrogel including the fabrication methodologies, interior structures, performances, antibacterial mechanisms, and applications of various antibacterial hydrogels is summarized. According to the bacteria‐killing modes of hydrogels, several representative hydrogels such as silver nanoparticles‐based hydrogel, photoresponsive hydrogel including photothermal and photocatalytic, self‐bacteria‐killing hydrogel such as inherent antibacterial peptides and cationic polymers, and antibiotics‐loading hydrogel are focused on. Furthermore, current challenges of antibacterial hydrogels are discussed and future perspectives in this field are also proposed.

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Rapid Fabrication of Self‐Healing, Conductive, and Injectable Gel as Dressings for Healing Wounds in Stretchable Parts of the Body

Cited by 172 publications

References 92 publications

Electrically Conductive Micropatterned Polyaniline-Poly(ethylene glycol) Composite Hydrogel

Electrically Conductive Micropatterned Polyaniline-Poly(ethylene glycol) Composite Hydrogel

Polymeric Materials with Antibacterial Activity: A Review

Antibacterial Hybrid Hydrogels

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