Rapid fabrication and screening of tailored functional 3D biomaterials: Validation in bone tissue repair – Part II

Combining "waste utilization" and "tissue to tissue" strategies to accelerate vascularization for bone repair

“…Developing predictable and sufficient vascular networks in scaffolds remains one of the major challenges for bone tissue engineering [ 35 ]. Various strategies for in vitro vascularization of the bone tissue scaffolds have been developed and implemented in the past [ [36] , [37] , [38] , [39] ]. Recently, the strategies for vascularization are based on the use of angiogenic growth factors, the implantation of endothelial cells, microfabrication of blood vessels through bioprinting, and microsurgical principles [ 40 , 41 ].Each strategy has its specific advantages and disadvantages.…”

“…These cells reside within the vessel walls of microvascular segments or, at the very least, tightly attach to perivascular locations [ 5 ]. This advantageous localization ensures that transplanted stem cells remain within their physiological stem cell ecological niche, thereby promoting survival, self-renewal, proliferation, mobilization, and differentiation [ 36 ]. In comparison to stem cells derived from a single adipose tissue, those associated with microvascular fragments showcase heightened proliferation rates and increased gene expression related to neural, osteogenic, and adipose differentiation [ 5 ].…”

CAM Model: Intriguing Natural Bioreactor for Sustainable Research and Reliable/Versatile Testing

“…The swelling and degradation ability of polymer matrix hydrogels makes them suitable for encapsulating and delivering numerous therapeutic agents, such as cells, growth factors, drugs, and genes, into tissue defects [ 167 , 168 ]. In addition, hydrogels are very often enriched with other molecules, such as, for example, acrylamine [ 169 ], heparin [ 170 ], and hyaluronic acid [ 171 ]. The latter is designed to treat periodontitis, a chronic biofilm-associated inflammatory disease of the tooth-supporting tissues that causes tooth loss.…”

Advances in Biomimetic Scaffolds for Hard Tissue Surgery

“…This Special Issue presents eleven contributions submitted by scholars with renowned backgrounds in scaffolds design, fabrication, functionalization, or clinical applications [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]; four of these contributions are valuable review articles, and seven are original new research articles. Thematically, according to the area of application, the contributions can be grouped into articles concerning the following:…”