Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases

Gagnon, Jean‐François; Postuma, Ronald B.; Mazza, Stéphanie; Doyon, Julien; Montplaisir, Jacques

doi:10.1016/s1474-4422(06)70441-0

Cited by 347 publications

(244 citation statements)

References 114 publications

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“…Imaging and autopsy studies suggest an association with neuropathological changes in the brainstem, such as neuronal loss and Lewy bodies in the locus coeruleus and the substantia nigra [520]. In a case series of 29 patients with RBD, 11 (38%) were diagnosed with PD about 13 years after the onset of RBD symptoms [521].…”

Section: Rem Sleep Behavior Disordermentioning

confidence: 99%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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Section: Rem Sleep Behavior Disordermentioning

confidence: 99%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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“…Analysis of EEG activity shows that relative to healthy controls, RBD patients have slower cortical EEG frequencies, which is an index of impaired cortical activation (Gagnon et al, 2006b). EEG slowing also occurs in Parkinson's disease and dementia (Soikkeli et al, 1991;Briel et al, 1999).…”

Section: Cortical Activation Is Impaired In Transgenic Micementioning

confidence: 99%

“…These areas also have reduced EEG activity during waking and NREM in RBD patients. Subcortical regions that contain GABA neurons are affected in RBD (Gagnon et al, 2006b;Boeve et al, 2007). These same GABA-rich regions modulate cortical activation and project to the cortical regions affected by EEG slowing (Jones, 2005).…”

Section: Inhibition and Eeg Slowing In Rbdmentioning

confidence: 99%

Impaired GABA and Glycine Transmission Triggers Cardinal Features of Rapid Eye Movement Sleep Behavior Disorder in Mice

Brooks¹,

Peever²

2011

J. Neurosci.

112

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Rapid eye movement (REM) sleep behavior disorder (RBD) is a neurological disease characterized by loss of normal REM motor inhibition and subsequent dream enactment. RBD is clinically relevant because it predicts neurodegenerative disease onset (e.g., Parkinson's disease) and is clinically problematic because it disrupts sleep and results in patient injuries and hospitalization. Even though the cause of RBD is unknown, multiple lines of evidence indicate that abnormal inhibitory transmission underlies the disorder. Here, we show that transgenic mice with deficient glycine and GABA transmission have a behavioral, motor, and sleep phenotype that recapitulates the cardinal features of RBD. Specifically, we show that mice with impaired glycine and GABA A receptor function exhibit REM motor behaviors, non-REM muscle twitches, sleep disruption, and EEG slowing-the defining disease features. Importantly, the RBD phenotype is rescued by drugs (e.g., clonazepam and melatonin) that are routinely used to treat human disease symptoms. Our findings are the first to identify a potential mechanism for RBD-we show that deficits in glycine-and GABA A -mediated inhibition trigger the full spectrum of RBD symptoms. We propose that these mice are a useful resource for investigating in vivo disease mechanisms and developing potential therapeutics for RBD.

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“…It is thought that excessive electromyographic (EMG) activity during REM sleep in RBD patients reflects dysfunction of the brainstem structures responsible for muscle atonia during REM sleep (2)(3)(4)(5). RBD is very common in several neurodegenerative diseases, including multiple system atrophy, dementia with Lewy bodies and Parkinson's disease (6)(7)(8). It is also rarely observed in some patients with focal lesions of the brainstem from various causes, including vascular diseases, multiple sclerosis and inflammatory lesions (9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Rapid Eye Movement Sleep Behavior Disorder in a Patient with Brainstem Lymphoma

et al. 2013

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Rapid eye movement (REM) sleep behavior disorder (RBD) is common in patients with neurodegenerative diseases. RBD occurring in a patient with brainstem lymphoma has not yet been reported. A 30-year-old man had an eleven-month history of violent motor and vocal behavior during sleep. Brain magnetic resonance imaging disclosed hypointensity T1 and hyperintensity T2 signals in the pontomesencephalic junction and at the upper/mid pons level. A stereotactic biopsy demonstrated the presence of diffuse large B-cell lymphoma. On polysomnography, there was enhanced submental and limb electromyographic tone and increased muscular activity during REM sleep. Chemotherapy diminished the dream-enacting behaviors. This case provides evidence that treatment aimed at the primary disease can partially improve the frequency of RBD.

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Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases

Cited by 347 publications

References 114 publications

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Impaired GABA and Glycine Transmission Triggers Cardinal Features of Rapid Eye Movement Sleep Behavior Disorder in Mice

Rapid Eye Movement Sleep Behavior Disorder in a Patient with Brainstem Lymphoma

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