Rapid Eye Movement Sleep Behavior Disorder in Children With Autism

Thirumalai, Shanti S.; Shubin, Richard; Robinson, Ricki

doi:10.1177/088307380201700304

Cited by 143 publications

(57 citation statements)

References 13 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the observed increased sleep latency may actually be related to difficulties with novelty and separation [Weiskop et al, 2005]. A more thorough examination of sleep architecture could point to specific aspects that are qualitatively altered in autism [Thirumalai et al, 2002]. There are only limited data regarding sleep latency, other behavioral aspects of sleep, or sleep architecture in autism; and no information regarding family members or twin pairs.…”

Section: Sleep Problemsmentioning

confidence: 99%

The potential role for emergence in autism

Anderson

2008

Autism Research

View full text Add to dashboard Cite

Although most research on autistic behavior has considered autism categorically, the increasingly apparent genetic and phenotypic complexities of autism are prompting a more dimensional approach to this area. The long-standing interest in a less categorical approach is made clear from a review of literature. The accumulating empirical support for viewing autism-related phenomena as separable and fractionable is outlined and includes data indicating that many of the behaviors occur in isolation in family members and the general population, are not highly correlated within individuals, and appear to be inherited separately. However, it is emphasized that some of the most common and characteristic phenomena observed in individuals diagnosed with autism do not run in their families. It is suggested that these novel, ''emergent,'' phenomena may arise in the individual from interacting configurations of co-occurring traits or from the interaction of genetic and biological factors underlying the traits. A number of autism-related phenomena including intellectual disability, seizures, persistence of primitive reflexes, stereotypies, self-injurious behavior, savant abilities, and morphological abnormalities, among others, are discussed as potentially being emergent. It is concluded that consideration of the role of emergence in autistic behavior and related phenomena should complement a reductionist approach and might help illuminate the components and complexities of autism.

show abstract

Section: Sleep Problemsmentioning

confidence: 99%

The potential role for emergence in autism

Anderson

2008

Autism Research

View full text Add to dashboard Cite

show abstract

“…5) Disordered sleep-wake cycles have been reported in persons with autism [81][82][83], and VIP is an important peptide in the suprachiasmatic nucleus of the hypothalamus where it is essential for the maintenance of sustained rhythm generation [119]. In addition, VIP in the amygdala has been implicated in rapid eye movement sleep [120] and rapid eye movement sleep disorder has been reported in children with autism [121]. 6) Results from examination of polymorphisms in the upstream region of the VPAC2 receptor gene suggest a potential link between this gene and the gastrointestinal and stereotypical behaviors in autistic persons [122].…”

Section: Vip In Neurodevelopmental Disorders Vip In Autismmentioning

confidence: 99%

Vasoactive Intestinal Peptide in Neurodevelopmental Disorders:Therapeutic Potential

Hill¹

2007

CPD

View full text Add to dashboard Cite

Abstract:Vasoactive intestinal peptide (VIP) mediates important events during the development of the nervous system. VIP can stimulate neuronogenesis as well as differentiation and neurite outgrowth; it can promote the survival of neurons and assist in neuronal repair; it is also anti-inflammatory and can modulate immune responses. In addition, VIP is necessary for the normal growth and development of the early postimplantation mouse embryo during the period when the major embryonic events are neural tube formation, neuronogenesis and expansion of the vascular system. Receptors for VIP appear during early postimplantation embryogenesis in the rodent and exhibit changing localization patterns throughout the development of the brain. During embryogenesis, unregulated VIP may have major and permanent consequences on the formation of the brain and may be a participating factor in disorders of neurodevelopment. VIP has been linked to autism, Down syndrome and fetal alcohol syndrome. This paper will review the role of VIP in neurodevelopment, its known involvement in neurodevelopmental disorders and propose ways in which VIP might be of therapeutic value.

show abstract

“…In a relatively large fraction of the population in neurodevelopmental disorders, disturbances in the balance of excitation and inhibition are commonly identified [Rennie and Boylan, 2003], including seizures and subclinical spike wave activity, perturbations in arousal mechanisms, and broadly defined disruption of homeostatic processes, such as sleep-wake cycle. For example, compared to the typical population, frank epilepsy or infantile spasms has a far greater incidence in neurodevelopmental disorders (3-to 30-fold greater risk) such as autism, fragile X, or Angelman syndromes [Thirumalai et al, 2002;Tuchman and Rapin, 2002;Rennie and Boylan, 2003]. The temporal onset of seizures may vary with regard to syndrome, reflecting potentially different mechanisms that create susceptibility of interneuronal circuitry.…”

Section: Interneuron Pathogenesis: a Point Of Convergence In Autism Amentioning

confidence: 98%

Autism and 15q11‐q13 disorders: Behavioral, genetic, and pathophysiological issues

Dykens

Sutcliffe

Levitt

2004

Ment. Retard. Dev. Disabil. Res. Rev.

View full text Add to dashboard Cite

New insights into biological factors that underlie autism may be gained by comparing autism to other neurodevelopmental disorders that have autistic features and relatively well-delineated genetic etiologies or neurobiological findings. This review moves beyond global diagnoses of autism and instead uses an endophenotypic approach to compare specific clusters of autistic symptomatology to features of chromosome 15q11-q13 disorders. Paternally or maternally derived deficiencies of 15q11-q13 result in Prader-Willi or Angelman syndromes, and we first use a global approach to review potential autism susceptibility genes in the 15q11-q13 region. We then use a more trait-based approach to suggest possible ties between specific phenotypic characteristics of autism and Prader-Willi syndrome, namely savant-like skills. We conclude with insights from pathophysiological studies that implicate altered development of specific neuron types and circuits in the cerebral cortex as part of the pathophysiological processes associated with autism and mental retardation.

show abstract

Rapid Eye Movement Sleep Behavior Disorder in Children With Autism

Cited by 143 publications

References 13 publications

The potential role for emergence in autism

The potential role for emergence in autism

Vasoactive Intestinal Peptide in Neurodevelopmental Disorders:Therapeutic Potential

Autism and 15q11‐q13 disorders: Behavioral, genetic, and pathophysiological issues

Contact Info

Product

Resources

About