Rapid evolution ofKlebsiella pneumoniaebiofilmsin vitrodelineates adaptive changes selected during infection
Greta Zaborskytė,
Patrícia Coelho,
Marie Wrande
et al.
Abstract:Biofilm formation facilitates infection by the opportunistic pathogenKlebsiella pneumoniae, primarily through indwelling medical devices. Here, we address howK. pneumoniaecan increase its biofilm capacity by experimental evolution of surface-attached biofilms to mimic catheter-associated infections. We observed rapid convergent evolution that altered or abolished capsule, modified the fimbrial adhesin MrkD, or increased production of fimbriae and cellulose via upregulated c-di-GMP-dependent pathways. However, … Show more
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