Rapid Evaluation of Water-in-Oil (w/o) Emulsion Stability by Turbidity Ratio Measurements

Song, M.; Jho, Sung-Ho; Kim, Jong-Yun; Kim, Jong-Duk

doi:10.1006/jcis.2000.7090

Cited by 64 publications

(30 citation statements)

References 9 publications

(9 reference statements)

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“…These include droplet size analysis, 15,16) light scattering, 15,17,18) and turbidity measurements. 19) We believe that our MRI method is better than conventional methods. T 2 mapping can depict slight changes in the emulsions with high sensitivity, and MRS is an effective tool for nondestructive component analysis.…”

Section: H-nmr Spectra Of Each Phase-separated Layer Acquired From Thmentioning

confidence: 86%

Stability of Mixed Preparations Consisting of Commercial Moisturizing Creams with an Ointment Base Investigated by Magnetic Resonance Imaging

Onuki

Funatani

Yamamoto

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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A moisturizing cream mixed with a steroid ointment is frequently prescribed to patients suffering from atopic dermatitis. However, there is a concern that the mixing operation causes destabilization. The present study was performed to investigate the stability of such preparations closely using magnetic resonance imaging (MRI). As sample preparations, five commercial moisturizing creams that are popular in Japan were mixed with an ointment base, a white petrolatum, at a volume ratio of 1 : 1. The mixed preparations were stored at 60°C to accelerate the destabilization processes. Subsequently, the phase separations induced by the storage test were monitored using MRI. Using advanced MR technologies including spin-spin relaxation time (T 2 ) mapping and MR spectroscopy, we successfully characterized the phase-separation behavior of the test samples. For most samples, phase separations developed by the bleeding of liquid oil components. From a sample consisting of an oil-in-water-type cream, Urepearl Cream 10%, a distinct phase-separation mode was observed, which was initiated by the aqueous component separating from the bottom part of the sample. The resultant phase separation was the most distinct among the test samples. To investigate the phase separation quantitatively and objectively, we conducted a histogram analysis on the acquired T 2 maps. The water-in-oil type creams were found to be much more stable after mixing with ointment base than those of oil-in-water type creams. This finding strongly supported the validity of the mixing operation traditionally conducted in pharmacies.Key words mixed external preparation; magnetic resonance imaging; quantitative T 2 map; emulsion stability Atopic dermatitis is one of the most common skin disorders in Japan. Dermatologists frequently prescribe moisturizing creams mixed with steroid ointments.1-4) This treatment approach is based on the concept that moisture retention of the skin is important for the treatment of atopic dermatitis, as is steroid therapy. To facilitate application of the cream and ointment, they are mixed in an operation that is widely performed at pharmacy level.Moisturizing creams are classified into two types: oilin-water (o/w) emulsions, which are composed of small oil droplets dispersed in a continuous aqueous phase, while water-in-oil (w/o) creams are composed of small water droplets dispersed in a continuous oily phase.5) The basic concept concerning the compatibility of the different types of emulsions with steroid ointments is described in the dispensing guidelines in Japan, Chozai Shishin.6) The guidelines show a greater preference for w/o-type moisturizing creams in mixing creams with ointments than for o/w-type creams. This description is often used as a rationale to argue that the mixing operation performed in the pharmacy is appropriate. However, as a whole, pharmaceutical emulsions are not designed under the assumption that they would be mixed with other preparations. Therefore, it remains a concern that the mixing operation could be a...

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Section: H-nmr Spectra Of Each Phase-separated Layer Acquired From Thmentioning

confidence: 86%

Stability of Mixed Preparations Consisting of Commercial Moisturizing Creams with an Ointment Base Investigated by Magnetic Resonance Imaging

Onuki

Funatani

Yamamoto

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Foyeke et al [75] investigated the interfacial properties of lipophilic nonionic surfactants of The amount of surfactant directly influences the dispersed droplet size and W/O emulsion stability. In the literature, most studies concluded that increasing the amount of surfactant reduces the droplet size and increase the emulsion stability [17,18,76]. The HLB values in Table 2.2 are not certain and may change according to the nature of oil, viscosity, and oil/water ratio [11,49].…”

Section: (Iv) Flocculationmentioning

confidence: 99%

“…The Oswald ripening is the fusion of smaller droplets into bigger droplets because of their Laplace pressures difference [15,17]. It is stated in many studies that using a co-surfactant in W/O emulsion enhanced the stability [16][17][18][19]. The required ratio of surfactants can be predicted from "Hydrophilic-Lipophilic Balance"…”

mentioning

confidence: 99%

Synthesis and characterization of multi‐hollow opaque polymer pigments

Asmaoğlu

Gündüz

Mavış

et al. 2016

J of Applied Polymer Sci

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“…Additionally, the optimization of formulations becomes more complex, especially concerning the determination of the required HLB. In order to reduce the time and experimental effort, several short-term methods are suggested in the literature to evaluate emulsion destabilization phenomena such as mean droplet size (21), conductivity (29), turbidity (30,31), and/or creaming layer measurements (17). Recently, the micro-emultocrit method was proposed as a tool to predict the emulsion stability (22).…”

Section: First Run Of Experimentsmentioning

confidence: 99%

Development and Evaluation of Emulsions from Carapa guianensis (Andiroba) Oil

et al. 2010

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Abstract. Carapa guianensis, a popular medicinal plant known as "Andiroba" in Brazil, has been used in traditional medicine as an insect repellent and anti-inflammatory product. Additionally, this seed oil has been reported in the literature as a repellent against Aedes aegypti. The aim of this work is to report on the emulsification of vegetable oils such as "Andiroba" oil by using a blend of nonionic surfactants (Span 80® and Tween 20®), using the critical hydrophilic-lipophilic balance (HLB) and pseudo-ternary diagram as tools to evaluate the system's stability. The emulsions were prepared by the inverse phase method. Several formulations were made according to a HLB spreadsheet design (from 4.3 to 16.7), and the products were stored at 25°C and 4°C. The emulsion stabilities were tested both long-and short-term, and the more stable one was used for the pseudo-ternary diagram study. The emulsions were successfully obtained by a couple of surfactants, and the HLB analysis showed that the required HLB of the oil was 16.7. To conclude, the pseudo-ternary diagram identified several characteristic regions such as emulsion, micro-emulsion, and separation of phases.

show abstract

Rapid Evaluation of Water-in-Oil (w/o) Emulsion Stability by Turbidity Ratio Measurements

Cited by 64 publications

References 9 publications

Stability of Mixed Preparations Consisting of Commercial Moisturizing Creams with an Ointment Base Investigated by Magnetic Resonance Imaging

Stability of Mixed Preparations Consisting of Commercial Moisturizing Creams with an Ointment Base Investigated by Magnetic Resonance Imaging

Synthesis and characterization of multi‐hollow opaque polymer pigments

Development and Evaluation of Emulsions from Carapa guianensis (Andiroba) Oil

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