Rapid Estimation of Left Ventricular Ejection Fraction in Acute Myocardial Infarction by Echocardiographic Wall Motion Analysis

Berning, J; Nielsen, Jens Rokkedal; Launbjerg, J; Fogh, Jan; Mickley, Hans; Andersen, Poul Erik

doi:10.1159/000175011

Cited by 123 publications

(82 citation statements)

References 2 publications

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“…LV ejection fraction (LVEF) was evaluated by 1 observer on the basis of the wall motion index score 30. LV systolic dysfunction was defined as LVEF <50% 23, 24, 25…”

Section: Methodsmentioning

confidence: 99%

Cardiac Time Intervals Measured by Tissue Doppler Imaging M‐mode: Association With Hypertension, Left Ventricular Geometry, and Future Ischemic Cardiovascular Diseases

Biering‐Sørensen

Møgelvang

Schnohr

et al. 2016

JAHA

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BackgroundWe hypothesized that the cardiac time intervals reveal reduced myocardial function in persons with hypertension and are strong predictors of future ischemic cardiovascular diseases in the general population.Methods and ResultsIn a large community‐based population study, cardiac function was evaluated in 1915 participants by using both conventional echocardiography and tissue Doppler imaging (TDI). The cardiac time intervals, including the isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT), and ejection time (ET), were obtained by TDI M‐mode through the mitral leaflet. IVCT/ET, IVRT/ET, and myocardial performance index [MPI=(IVRT+IVCT)/ET] were calculated. After multivariable adjustment for clinical variables the IVRT, IVRT/ET, and MPI, remained significantly impaired in persons with hypertension (n=826) compared with participants without hypertension (n=1082). Additionally, they displayed a significant dose–response relationship, between increasing severity of elevated blood pressure and increasing left ventricular mass index (P<0.001 for all). Further, during follow‐up of a median of 10.7 years, 435 had an ischemic cardiovascular disease (ischemic heart disease, peripheral arterial disease, or stroke). The IVRT/ET and MPI were powerful and independent predictors of future cardiovascular disease, especially in participants with known hypertension. They provide prognostic information incremental to clinical variables from the Framingham Risk Score, the SCORE risk chart, and the European Society of Hypertension/European Society of Cardiology risk chart.ConclusionThe cardiac time intervals identify impaired cardiac function in individuals with hypertension, not only independent of conventional risk factors but also in participants with a normal conventional echocardiographic examination. The IVRT/ET and MPI are independent predictors of future cardiovascular disease especially in participants with known hypertension.

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“…LV ejection fraction (LVEF) was evaluated by 1 observer on the basis of the wall motion index score 30. LV systolic dysfunction was defined as LVEF <50% 23, 24, 25…”

Section: Methodsmentioning

confidence: 99%

Cardiac Time Intervals Measured by Tissue Doppler Imaging M‐mode: Association With Hypertension, Left Ventricular Geometry, and Future Ischemic Cardiovascular Diseases

Biering‐Sørensen

Møgelvang

Schnohr

et al. 2016

JAHA

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“…WMI was calculated by dividing the sum of the scores by the number of segments analyzed. A satisfactory approximation of LVEF in percent can be derived by multiplying WMI by 30 [24].…”

Section: Echocardiography and Data Analysismentioning

confidence: 99%

Prognostic importance of a short deceleration time in symptomatic congestive heart failure☆

Akkan

Kjærgaard

Møller

et al. 2008

European J of Heart Fail

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Aims: A restrictive transmitral filling (RF) pattern predicts increased mortality in heart failure (HF) with reduced left ventricular (LV) systolic function. We performed a combined evaluation of LV function and RF for prognosis in patients with HF with and without systolic dysfunction. Methods and results: Doppler echocardiography was performed in 972 patients with symptomatic HF. RF was considered present when deceleration time (DT) was ≤140 ms and non-RF when N 140 ms. A DT N 240 ms was defined as delayed relaxation. During a median of 51 months the unadjusted all-cause mortality rates were significantly increased among patients with RF vs. the non-RF group (1-and 4-year mortality was 25% and 54% vs. 17% and 43%). In a multivariable model, RF was a significant predictor of all-cause mortality (hazard ratio (HR) = 2.0, 95% confidence interval (CI):1.5-2.6) whereas delayed relaxation was without prognostic importance (HR = 0.9, CI:0.5-1.6). Repeating the multivariable model in subgroups of wall motion index (WMI) showed that RF was a strong predictor of mortality independent of WMI. For patients with LVEF of at least 50%, HR for RF was 2.0 (CI:1.1-3.4; p = 0.02) and interaction between LVEF and RF was not significant. Conclusion: In a heterogeneous population hospitalised for symptomatic HF a restrictive transmitral filling pattern, defined as shortened deceleration time, during hospitalisation is an ominous prognostic sign independent of LV systolic function.

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“…All echocardiograms were examined offline by 1 expert using the EchoPAC software version 6.4.3f1 (GE Medical). The 16 standard segments, as suggested by the American Society of Echocardiography (21 ), were used for evaluation of left ventricular ejection fraction (22)(23)(24).…”

Section: Echocardiographymentioning

confidence: 99%

Impact of Hemoglobin on Plasma Pro-B-Type Natriuretic Peptide Concentrations in the General Population

et al. 2007

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Background: Age, sex, and renal function contribute to variations in plasma concentrations of B-type natriuretic peptide (BNP) and its molecular precursor (proBNP). Recent studies indicate that anemia may also affect proBNP concentrations in patients with heart failure or stroke. However, the impact of hemoglobin status on proBNP concentrations has not been established in the general population. Methods: In the 4th examination in the Copenhagen City Heart Study, we performed a nested case-control study of 6238 individuals from a Danish general population. Of these, 3497 randomly selected participants also underwent an echocardiographic examination. The population was stratified into groups depending on health and hemoglobin status. Correlations between hemoglobin and proBNP concentrations were examined by simple and multiple regression analyses, adjusted for variables known to influence the proBNP plasma concentration. Results: The mean proBNP concentration was increased 1.7-fold in the group with anemia vs the nonanemic group [mean (SD) 42 (45) pmol/L vs 25 (29) pmol/L, P <0.0001, n ‫؍‬ 5892]. Multiple regression analysis confirmed an independent effect of hemoglobin on proBNP concentrations. In a selected subgroup without signs or symptoms of heart disease (n ‫؍‬ 2855), lower hemoglobin concentrations, defined as <120 g/L in women and

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Rapid Estimation of Left Ventricular Ejection Fraction in Acute Myocardial Infarction by Echocardiographic Wall Motion Analysis

Cited by 123 publications

References 2 publications

Cardiac Time Intervals Measured by Tissue Doppler Imaging M‐mode: Association With Hypertension, Left Ventricular Geometry, and Future Ischemic Cardiovascular Diseases

Cardiac Time Intervals Measured by Tissue Doppler Imaging M‐mode: Association With Hypertension, Left Ventricular Geometry, and Future Ischemic Cardiovascular Diseases

Prognostic importance of a short deceleration time in symptomatic congestive heart failure☆

Impact of Hemoglobin on Plasma Pro-B-Type Natriuretic Peptide Concentrations in the General Population

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