Rapid estimation of cartilage T2 based on double echo at steady state (DESS) with 3 Tesla

Welsch, Goetz H.; Scheffler, Klaus; Mamisch, Tallal C.; Hughes, Timothy; Millington, Steven; Deimling, M.; Trattnig, Siegfried

doi:10.1002/mrm.22036

Cited by 78 publications

(139 citation statements)

References 17 publications

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“…The other two states showed a dependence on both TE1 and dTE with different oscillation frequencies, and reached maximum amplitude whenever s 0,1 (Eqs. [6] and [7]) was a multiple of the in-phase time, resulting in a constructive summation of their compartments (Eq. [9]).…”

Section: Resultsmentioning

confidence: 99%

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Exploiting multicompartment effects in triple‐echo steady‐state T₂ mapping for fat fraction quantification

Liu

Steingoetter

Curcic

et al. 2017

Magnetic Resonance in Med

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Purpose: To investigate and exploit the effect of intravoxel offresonance compartments in the triple-echo steady-state (TESS) sequence without fat suppression for T 2 mapping and to leverage the results for fat fraction quantification. Methods: In multicompartment tissue, where at least one compartment is excited off-resonance, the total signal exhibits periodic modulations as a function of echo time (TE). Simulated multicompartment TESS signals were synthesized at various TEs. Fat emulsion phantoms were prepared and scanned at the same TE combinations using TESS. In vivo knee data were obtained with TESS to validate the simulations. The multicompartment effect was exploited for fat fraction quantification in the stomach by acquiring TESS signals at two TE combinations. Results: Simulated and measured multicompartment signal intensities were in good agreement. Multicompartment effects caused erroneous T 2 offsets, even at low water-fat ratios. The choice of TE caused T 2 variations of as much as 28% in cartilage. The feasibility of fat fraction quantification to monitor the decrease of fat content in the stomach during digestion is demonstrated. Conclusions: Intravoxel off-resonance compartments are a confounding factor for T 2 quantification using TESS, causing errors that are dependent on the TE. At the same time, offresonance effects may allow for efficient fat fraction mapping using steady-state imaging.

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Section: Resultsmentioning

confidence: 99%

“…The frequency of these periodical modulations varies for the different states and imaging sequences (Eqs. [4][5][6][7][8]), whereas the amplitude of the modulations is dependent on ff. When using a more realistic fat model with more than one spectral fat peak, Equation [9] becomes…”

Section: Theorymentioning

confidence: 99%

Exploiting multicompartment effects in triple‐echo steady‐state T₂ mapping for fat fraction quantification

Liu

Steingoetter

Curcic

et al. 2017

Magnetic Resonance in Med

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“…Die T2 DESS erwies sich als nützlich für die Defekterkennung im Gelenkbereich (Imhof et al 2002) und zum hoch spezifischen Nachweis von Frakturen unter Beteiligung der Wachstumsfuge (Stock 2005). Diese Sequenz kombiniert zwei Echos und verbessert den T2-Kontrast (Welsch et al 2009). Der Epiphysenfugenknorpel konnte damit klar abgrenzt werden, was besonders für weiterführende Untersuchungen an erkrankten Knorpelabschnitten beim Pferd von Interesse sein könnte.…”

Section: Materials Und Methodenunclassified

MR Imaging of the cartilaginous growthstructures of the distal radius of the horse – an age related study

Troillet¹,

Brehm²,

Flatz³

et al. 2011

PHK

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ZusammenfassungEine magnetresonanztomographische Untersuchung des distalen Abschnittes des Radius wurde an 28 Gliedmaßenpräparaten von Pferden im Alter von zwei Tagen bis 17 Jahren durchgeführt. Die knorpeligen Wachstumsregionen des distalen Radius wurden mit besonderem Hinblick auf seine Epiphysenfuge deskriptiv erfasst und altersbedingte Unterschiede definiert. Die durchschnittliche Dicke des sich darstellenden Epiphysenfugenknorpels wurde in verschiedenen Sequenzen in zwei Ebenen vermessen und in Bezug zum Alter der Spendertiere gesetzt. Der hyaline Knorpel der untersuchten Region war mit den gewählten Sequenzen sehr gut zu beurteilen. Die knorpeligen Anteile der Epiund Apophysenfuge konnten deutlich dargestellt werden. Angrenzende Strukturen wie die subchondrale Knochenplatte der Radiusepiphyse und die Mineralisationszone der Epiphysenfuge konnten ebenfalls abgebildet werden. Epiphysenfugennarben waren bis zu einem hohen Alter nachweisbar. Die Untersuchungsmaterialien waren auf Grund ähnlicher altersbedingter Unterschiede fünf Gruppen zuzuordnen. Die alterskorrelierende Abnahme der mittleren Epiphysenfugenknorpeldicke konnte mittels Vermessungen der Knorpelschichten graphisch dargestellt werden. Die Magnetresonanztomographie (MRT) hat sich als geeignetes Verfahren erwiesen, die knorpeligen Strukturen der Wachstumsregion des distalen Radius des Pferdes bildlich wiederzugeben. Altersabhängige strukturelle Unterschiede konnten im MRT dargestellt werden. Damit leistet die vorgestellte Studie einen Beitrag zur Darstellung der physiologischen anatomischen Verhältnisse der Wachstumsknorpel im Bereich des distalen Radius.Schlüsselwörter: Pferd / Magnetresonanztomographie / Radius / Epiphysenfuge / Knorpel / bildgebende Diagnostik MR Imaging of the cartilaginous growthstructures of the distal radius of the horse -an age related study 28 cadaver limb segments including the distal radius of 28 orthopedically sound horses of diverse breeds aged from 2 days to 17 years were examined by magnetic resonance imaging (MRI). The limbs were examined in four different sequences (T1w-SE, T2w-TSE, PD-SE, T2 DESS-GE) and in two planes (sagittal, dorsal). The region of growth with respect to the physis of the distal radial bone was documented descriptively. Age related changes regarding the cartilaginous structures within this region were distinguished. Consecutively the average thickness of the obtainable cartilage zone of the physis was measured using two sequences (T1w-SE, T2 DESS-GE). The results were compared among each other and to the increasing age of the examined samples. The hyaline cartilage of the examined area could be clearly defined by the sequences used. Cartilaginous structures of the epiphyses and apophysis were considered to be well assessable with MRI. In young foals proximal to the physeal cartilage a zone of provisional calcification could be documented whereas a hypointense epiphyseal subchondral bone plate was visible adjacent distally. In adult horses physeal scars in that region of the growthplate were clea...

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“…The iDESS sequence originates from the double-echo steady-state (DESS) technique, [20][21][22][23][24][25][26][27] with the main difference in the order of echo acquisition. Figure 1(a) plots the schematic sequence diagram including the readout gradient waveforms of the DESS sequence.…”

Section: A the Idess Techniquementioning

confidence: 99%

“…The two echoes, fast imaging with steady-state precession (FISP) and reverse fast imaging with steady-state precession (PSIF), are acquired concurrently in a readout gradient. 20,26 Figure 1 (b) plots the readout gradient of the iDESS sequence, which is proposed for midbrain imaging in this study. In iDESS acquisition, two changes are made when compared to the DESS sequence: (1) the temporal acquisition order of FISP and PSIF has been reversed to enable longer phase evolutions by adjusting the pre-and rephrasing gradient areas to thrice of those in DESS and (2) separated readout gradients are used to acquire PSIF and FISP, enabling flexible adjustment of TEs for both echoes.…”

Section: A the Idess Techniquementioning

confidence: 99%

Efficient imaging of midbrain nuclei using inverse double‐echo steady‐state acquisition a)

Chang

Chao

et al. 2015

Medical Physics

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Purpose: Imaging of midbrain nuclei using T2-or T2*-weighted MRI often entails long echo time, leading to long scan time. In this study, an inverse double-echo steady-state (iDESS) technique is proposed for efficiently depicting midbrain nuclei. Methods: Thirteen healthy subjects participated in this study. iDESS was performed along with two sets of T2*-weighted spoiled gradient-echo images (SPGR1, with scan time identical to iDESS and SPGR2, using clinical scanning parameters as a reference standard) for comparison. Generation of iDESS composite images combining two echo signals was optimized for maximal contrast-to-noise ratio (CNR) between the red nuclei and surrounding tissues. Signal-to-noise ratios (SNRs) were calculated from the occipital lobe. Comparison was also made using phase-enhanced images as in standard susceptibility-weighted imaging (SWI). Results: The iDESS images present significantly higher SNR efficiency (171.3) than SPGR1 (158.7, p = 0.013) and SPGR2 (95.5, p < 10 −8). iDESS CNR efficiency (19.2) is also significantly greater than SPGR1 (6.9, p < 10) and SPGR2 (14.3, p = 0.0016). Compared with DESS, iDESS provides further advantage on enhanced phase information and hence improved contrast on SWI-processed images. Conclusions: iDESS efficiently depicts midbrain nuclei with improved CNR efficiency, increased SNR efficiency, and reduced scan time and is less prone to susceptibility signal loss from air-tissue interfaces. C 2015 American Association of Physicists in Medicine.

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Rapid estimation of cartilage T2 based on double echo at steady state (DESS) with 3 Tesla

Cited by 78 publications

References 17 publications

Exploiting multicompartment effects in triple‐echo steady‐state T₂ mapping for fat fraction quantification

Exploiting multicompartment effects in triple‐echo steady‐state T₂ mapping for fat fraction quantification

MR Imaging of the cartilaginous growthstructures of the distal radius of the horse – an age related study

Efficient imaging of midbrain nuclei using inverse double‐echo steady‐state acquisition a)

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Rapid estimation of cartilage T2 based on double echo at steady state (DESS) with 3 Tesla

Cited by 78 publications

References 17 publications

Exploiting multicompartment effects in triple‐echo steady‐state T2 mapping for fat fraction quantification

Exploiting multicompartment effects in triple‐echo steady‐state T2 mapping for fat fraction quantification

MR Imaging of the cartilaginous growthstructures of the distal radius of the horse – an age related study

Efficient imaging of midbrain nuclei using inverse double‐echo steady‐state acquisition a)

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Exploiting multicompartment effects in triple‐echo steady‐state T₂ mapping for fat fraction quantification

Exploiting multicompartment effects in triple‐echo steady‐state T₂ mapping for fat fraction quantification