Rapid Dissolution of Gallstones by Methyl Tert-Butyl Ether

“…Allen et al (80) Clinical symptoms observed in rats and mice exposed to 29,000 mg/mi air for 6 hr over 13 consecutive days include hypoactivity, ataxia, and periocular irritation, decreased startle and pain reflexes, and decreased muscle tone. These symptoms were reversible, and no mortality was observed among the rats and mice (79,81).…”

Section: Acute Toxicity In Humansmentioning

confidence: 99%

“…The molecular formula for benzene is C6H6, the molecular weight is 78.11 g/mole, the boiling point is 80.10 C, the vapor pressure is 100 mm Hg at 26.1°C, and the flash point is -11°C (14). The conversion factor from parts per million volume to milligrams per cubic meter is 3.19.…”

Section: Acute Toxicity Of Specific Compoundsmentioning

confidence: 99%

Acute toxicity of gasoline and some additives.

Reese

Kimbrough

1993

Environ Health Perspect

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The acute toxicity of gasoline; its components benzene, toluene, and xylene; and the additives ethanol, methanol, and methyl tertiary butyl ether are reviewed. All of these chemicals are only moderately to mildly toxic at acute doses. Because of their volatility, these compounds are not extensively absorbed dermally unless the exposed skin is occluded. Absorption through the lungs and the gastrointestinal tract is quite efficient. After ingestion, the principal danger for a number of these chemicals, particularly gasoline, is aspiration pneumonia, which occurs mainly in children. It is currently not clear whether aspiration pneumonia would still be a problem if gasoline were diluted with ethanol or methanol. During the normal use of gasoline or mixtures of gasoline and the other solvents as a fuel, exposures would be much lower than the doses that have resulted in poisoning. No acute toxic health effects would occur during the normal course of using automotive fuels.

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“…The use of MTBE as a therapeutic agent for dissolving gallstones (12) has provided information regarding the side effects in humans of MTBE administered by infusion. These studies, however, do not provide data relevant to the evaluation of MTBE neurotoxicity.…”

Section: Methyl Tertiary Butyl Ethermentioning

confidence: 99%

Neurotoxic effects of gasoline and gasoline constituents.

Burbacher

1993

Environ Health Perspect

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This overview was developed as part of a symposium on noncancer end points of gasoline and key gasoline components. The specific components included are methyl tertiary butyl ether, ethyl tertiary butyl ether, tertiary amyl methyl ether, butadiene, benzene, xylene, toluene, methyl alcohol, and ethyl alcohol. The overview focuses on neurotoxic effects related to chronic low-level exposures. A few general conclusions and recommendations can be made based on the results of the studies to date. a) All the compounds reviewed are neuroactive and, as such, should be examined for their neurotoxicity. b) For most of the compounds, there is a substantial margin of safety between the current permissible exposure levels and levels that would be expected to cause overt signs of neurotoxicity in humans. This is not the case for xylene, toluene, and methanol, however, where neurologic effects are observed at or below the current Threshold Limit Value. c) For most of the compounds, the relationship between chronic low-level exposure and subtle neurotoxic effects has not been studied. Studies therefore should focus on examining the dose-response relationship between chronic low-level exposure and subtle changes in central nervous system function.

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Rapid Dissolution of Gallstones by Methyl Tert-Butyl Ether

Cited by 252 publications

References 7 publications

Gallstone dissolution with methyl-tert-butyl ether via percutaneous cholecystostomy: success and caveats

Gallstone dissolution with methyl-tert-butyl ether via percutaneous cholecystostomy: success and caveats

Acute toxicity of gasoline and some additives.

Neurotoxic effects of gasoline and gasoline constituents.

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