Rapid Displacement of Dengue Virus Type 1 by Type 4, Pacific Region, 2007–2009

Li, Dongsheng; Li, Wen; Guigon, Aurélie; Mostyn, Candice; Grant, Richard; Aaskov, John

doi:10.3201/eid1601.091275

Cited by 42 publications

(50 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Delayed dengue case identification often occurs in areas with limited diagnostics or surveillance resources, especially where dengue outbreaks are episodic or have been under-recognized (e.g., Africa and Oceania) (10,11). These factors decrease health care provider awareness to include dengue in the differential diagnosis with other acute febrile illnesses (AFIs) such as malaria, leptospirosis, and influenza (12).…”

mentioning

confidence: 99%

Use of a Rapid Test for Diagnosis of Dengue during Suspected Dengue Outbreaks in Resource-Limited Regions

Hunsperger

Sharp

Lalita³

et al. 2016

J Clin Microbiol

View full text Add to dashboard Cite

G lobally, over 2.5 billion people are estimated to be at risk of dengue virus (DENV) infection with an estimated 96 million symptomatic cases of dengue occurring annually (1). Despite ongoing research efforts, there are no sustainable vector control approaches or effective antiviral drugs to prevent or treat dengue, and vaccines have only recently been licensed by few countries and with suboptimal efficacy (2, 3, 4, 5). However, improvements in patient clinical management has been shown to reduce mortality among patients with severe dengue from 5% to Ͻ0.5% (6-9).Delayed dengue case identification often occurs in areas with limited diagnostics or surveillance resources, especially where dengue outbreaks are episodic or have been under-recognized (e.g., Africa and Oceania) (10, 11). These factors decrease health care provider awareness to include dengue in the differential diagnosis with other acute febrile illnesses (AFIs) such as malaria, leptospirosis, and influenza (12). Lastly, minimal or no laboratory infrastructure to conduct standard dengue diagnostic assays or perform them in a timely manner limits their utility for case management (13).Laboratory diagnosis of dengue can be achieved with a single serum specimen obtained during the febrile phase of the illness by testing for DENV analytes (e.g., nucleic acid, nonstructural protein 1 [NS1], and anti-DENV IgM) (14). DENV viremia occurs for up to 7 days after the onset of fever, and anti-DENV IgM begins to appear around 3 days after fever onset (15, 16). Although detection of DENV nucleic acid by real-time reverse transcriptase PCR (rRT-PCR) is the most sensitive and specific means to detect DENV viremia (17), immunoassays to detect DENV NS1 antigen provide acceptable levels of detection sensitivity and specificity (18,19). Immunoassays with good sensitivities and specificities to detect anti-DENV IgM are also widely available (20). However, both of these diagnostic approaches are instrument dependent and require facilities capable of performing complex diagnostic tests.The availability of dengue rapid diagnostic tests (RDTs) has the potential to change the current situation in resource-limited areas and improve dengue clinical management. We evaluated an RDT that detected both DENV NS1 antigen and anti-DENV IgM for its ability to provide accurate information for detecting dengue from outbreaks as the main cause of febrile illness in areas without ongoing laboratory testing. In all settings, a suspected dengue case was defined as a person with an AFI presenting for medical care. Serum specimens were collected from all suspected dengue cases upon initial presentation along with patient demographics, days post onset of illness (DPO), and specimen collection date (Table 1). Second convalescent specimens were not collected for patients, and only specimens collected upon patient presentation to hospital or clinic were used in this study. MATERIALS AND METHODS Study design. The Centers for Disease Control and PreventionDiagnostic testing. The RDT used during each ...

show abstract

mentioning

confidence: 99%

Use of a Rapid Test for Diagnosis of Dengue during Suspected Dengue Outbreaks in Resource-Limited Regions

Hunsperger

Sharp

Lalita³

et al. 2016

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Knowledge of the serotype and genotype of DENV is important because the appearance of a "new" DENV serotype, which differs from that currently circulating, often is associated with major outbreaks of dengue due to the new serotype. 7,16,20 As more DENV genotype data becomes available, Pacific Island Communities may gain a clearer idea of from where most DENV introductions are coming and be able to undertake risk mitigation activities.…”

Section: Discussionmentioning

confidence: 99%

“…30 Nucleotide sequences were aligned using ClustalW and phylogenetic analyses were performed with Maximum Likelihood based on the Kimura 2-parameter method, 31 with 1000 bootstrap replicates. 32 Previously published E gene sequences available on Genbank or provided by Li et al 16 were included in the phylogenetic analyses.…”

Section: Nucleotide Sequencing and Genotyping Of Denvmentioning

confidence: 99%

“…17 Introduction of a new DENV represents a high risk of serotype replacement and of major outbreaks due to the new serotype. 7,16,20 provide diagnostic and reference support as requested. However, because the shipment of frozen human sera is expensive and subject to restrictive regulations, routine laboratories in PICs send samples only occasionally to the reference centers and usually only to confirm the etiology of an outbreak.…”

mentioning

confidence: 99%

“…It spread to an increasing number of PICs after the second half of 2008 and caused several epidemics during the following years. [15][16][17][18] Concomitantly, DENV-2 was detected in Yap State, Federated States of Micronesia in 2011. 19 In contrast to the epidemiology of dengue in hyper-endemic continental regions of Asia and the Americas, where multiple DENV serotypes/genotypes co-circulate, there usually is long-term transmission of only a single DENV serotype in the PICs.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Use of serum and blood samples on filter paper to improve the surveillance of dengue in Pacific Island Countries

Aubry

Roche

Dupont‐Rouzeyrol

et al. 2012

Journal of Clinical Virology

Self Cite

View full text Add to dashboard Cite

Detection of dengue virus type 4 in Easter Island, Chile

et al. 2011

View full text Add to dashboard Cite

We report the detection of dengue virus type 4 (DENV-4) for the first time in Easter Island, Chile. The virus was detected in serum samples of two patients treated at the Hospital in Easter Island. The two samples were IgM positive, and the infection was confirmed by RT-PCR and genetic sequencing; viral isolation was possible with one of them. The Easter Island isolates were most closely related to genotype II of dengue type 4.

show abstract

Rapid Displacement of Dengue Virus Type 1 by Type 4, Pacific Region, 2007–2009

Abstract: Since 2000–2001, dengue virus type 1 has circulated in the Pacific region. However, in 2007, type 4 reemerged and has almost completely displaced the strains of type 1. If only 1 serotype circulates at any time and is replaced approximately every 5 years, DENV-3 may reappear in 2012.

Cited by 42 publications

References 6 publications

Use of a Rapid Test for Diagnosis of Dengue during Suspected Dengue Outbreaks in Resource-Limited Regions

Use of a Rapid Test for Diagnosis of Dengue during Suspected Dengue Outbreaks in Resource-Limited Regions

Use of serum and blood samples on filter paper to improve the surveillance of dengue in Pacific Island Countries

Detection of dengue virus type 4 in Easter Island, Chile

Contact Info

Product

Resources

About