Rapid discrimination of Panax notogeinseng of different grades by FT-IR and 2DCOS-IR

Ma, Fang; Chen, Jian‐Bo; Wu, Xian‐Xue; Zhou, Qun; Sun, Su-Qin

doi:10.1016/j.molstruc.2016.02.087

Cited by 35 publications

(10 citation statements)

References 20 publications

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“…QC methods for herbal drugs have been published and reviewed using FT-IR and Raman spectroscopy [38,39]. Different grades of Panax notoginseng powders can be directly differentiated by using FT-IR and 2D FT-IR [40]. A combination of ATR-FTIR micro-spectroscopy imaging can be applied directly for identifying complex mixtures of powdered herbal drugs [41].…”

Section: Chemical Profiling Methods As Qc Tool For Herbal Medicinesmentioning

confidence: 99%

Recent Development of Quality Control Methods for Herbal Derived Drug Preparations

Indrayanto

2018

Natural Product Communications

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Pharmaceutical industries should apply rigorous QC (quality control) to ensure the consistency, safety, and efficacy of their herbal derived drug-preparations. QC must be performed at every stage of the production line i.e. incoming raw materials, extractions, in-process control, finished products and keeping samples. Due to the complex nature of the chemical content of herbal drugs, two approaches to QC should be taken, that is quantitative determination of the selected marker(s) compound(s), and metabolite profiling. Contamination of herbal medicines by heavy metals, pesticides, toxic metabolites, microbial toxins, pathogenic microorganisms and other foreign matter should also be evaluated. A combination of chemical profiling and multivariate analysis (MVA) is recommended as the QC tool for the botanical identification method (BIM) of herbs, extracts, herb materials, and herbal drug preparations. Microscopic methods, DNA profiling or chemical marker(s) are not recommended for use as the sole BIM due to the lack of specificity. Only markers that meet certain criteria i.e. quality active (QA) markers can be utilized as a QC tool. The limit specification range of markers used as QC tools should be described in the analytical target profile (ATP). To gain reliable results of any analysis that has been performed at any QC laboratory, the analysis method must be validated according to the newest guidance. Sample detection limit of any toxic compound(s) should be lower than its cutoff value and MPL. The reliability of any results of analysis of a QC laboratory must be evaluated by using QC-samples for each series of measurements.

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Section: Chemical Profiling Methods As Qc Tool For Herbal Medicinesmentioning

confidence: 99%

Recent Development of Quality Control Methods for Herbal Derived Drug Preparations

Indrayanto

2018

Natural Product Communications

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“…The peak at 1,368 cm À1 corresponded to NO 3 À , indicating the signature of nitrate in the samples. 52 The peak at 53 The peaks at 923 and 862 cm À1 represented the stretching vibration of C-C and the bending vibration of C-H, respectively. 54 According to the original spectrum, the different origins could not be directly discriminated from the spectra only by the naked eye; this was owing to the similar chemical composition of P. notoginseng samples.…”

Section: Atr-ftir Spectral Analysis and Preprocessingmentioning

confidence: 99%

Anticoagulant activity analysis and origin identification of Panax notoginseng using HPLC and ATR‐FTIR spectroscopy

Cui

Liu

et al. 2022

Phytochemical Analysis

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Introduction Panax notoginseng is one of the traditional precious and bulk‐traded medicinal materials in China. Its anticoagulant activity is related to its saponin composition. However, the correlation between saponins and anticoagulant activities in P. notoginseng from different origins and identification of the origins have been rarely reported. Objectives We aimed to analyze the correlation of components and activities of P. notoginseng from different origins and develop a rapid P. notoginseng origin identification method. Materials and methods Pharmacological experiments, HPLC, and ATR‐FTIR spectroscopy (variable selection) combined with chemometrics methods of P. notoginseng main roots from four different origins (359 individuals) in Yunnan Province were conducted. Results The pharmacological experiments and HPLC showed that the saponin content of P. notoginseng main roots was not significantly different. It was the highest in main roots from Wenshan Prefecture (9.86%). The coagulation time was prolonged to observe the strongest effect (4.99 s), and the anticoagulant activity was positively correlated with the contents of the three saponins. The content of ginsenoside Rg1 had the greatest influence on the anticoagulant effect. The results of spectroscopy combined with chemometrics show that the variable selection method could extract a small number of variables containing valid information and improve the performance of the model. The variable importance in projection has the best ability to identify the origins of P. notoginseng; the accuracy of the training set and the test set was 0.975 and 0.984, respectively. Conclusion This method is a powerful analytical tool for the activity analysis and identification of Chinese medicinal materials from different origins.

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“…47 The band near 1640 cm À1 may contain the bending vibration absorption peak of the hydroxyl group and the stretching vibration absorption of the conjugate carbonyl group, as well as the vibration absorption of the aromatic compound skeleton. 45 Small band 1250 cm À1 is assigned to the asymmetric vibration of (═C-O-C) or attributed to the vibration of (-C(CH 3 ) 2 -), which can be found in C-4 or C-25 of dammarane saponins. 48 In addition, the peak near 1039 cm À1 was attributed to C-C-O or C-C-OH vibration.…”

Section: Spectral Features Interpretationmentioning

confidence: 99%

Multisource information fusion strategies of mass spectrometry and Fourier transform infrared spectroscopy data for authenticating the age and parts of Vietnamese ginseng

Liu

Zuo

et al. 2021

Journal of Chemometrics

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Aiming at two different classification tasks in the field of quality evaluation of valuable Chinese herbal medicine, the applicability of data fusion strategy based on different complementary analysis techniques was studied. In this study, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and ultra-performance liquid chromatography quadrupole timeof-flight mass spectrometry (UPLC-QTOF/MS) were used to analyze the different parts (including roots, stems, leaves, and fibrils) of 2-to 5-year-old Vietnamese ginseng. The multivariate classification models (orthogonal partial least squares discrimination analysis, OPLS-DA; support vector machine, SVM) were established using low-level and mid-level data fusion methods to identify different parts and age of Vietnamese ginseng. The OPLS-DA model have shown that the fusion data matrix with low-level fusion processing could separate Vietnamese ginseng samples with different growth years to the greatest extent, whereas the single data matrix had partial overlap. But 100% of prediction set classification accuracy could be achieved. The SVM model combined with two parameter optimization algorithms (grid search, GS; genetic algorithm, GA) was used to identify Vietnamese ginseng samples with different ages. The mid-level fusion strategy based on the recursive feature elimination (RFE) features variable extraction method was more suitable for SVM model. In the model established by combining the two parameter optimization methods, the identification effect can reach 83.33%. The results showed that data fusion, as an effective strategy, could distinguish different ages and parts of Vietnamese ginseng.

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Rapid discrimination of Panax notogeinseng of different grades by FT-IR and 2DCOS-IR

Cited by 35 publications

References 20 publications

Recent Development of Quality Control Methods for Herbal Derived Drug Preparations

Recent Development of Quality Control Methods for Herbal Derived Drug Preparations

Anticoagulant activity analysis and origin identification of Panax notoginseng using HPLC and ATR‐FTIR spectroscopy

Multisource information fusion strategies of mass spectrometry and Fourier transform infrared spectroscopy data for authenticating the age and parts of Vietnamese ginseng

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