Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunisation with conjugate vaccines

Peltola, Heikki; Kilpi, Terhi; Anttila, Marja

doi:10.1016/0140-6736(92)92117-x

Cited by 289 publications

(103 citation statements)

References 20 publications

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“…Sequelas podem ocorrer, por vezes incapacitantes 3,12,20 . Na década atual, diversos países conseguiram reduzir muito a prevalência de meningites bacterianas na população, implantando o uso rotineiro da vacina conjugada para H. influenzae tipo b 1,11,21,23,25,26 .…”

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Etiologia de meningites bacterianas em uma amostra da população de Salvador - Bahia

Nascimento‐Carvalho

Moreno-Carvalho²

1998

Arq. Neuro-Psiquiatr.

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As meningites bacterianas constituem patologia importante na faixa etária pediátrica. Com o objetivo de conhecer a distribuição da etiologia desta patologia em uma amostra da população de Salvador, Bahia, foram analisados, retrospectivamente, 7000 exames de líquor, realizados entre setembro de 1988 e agosto de 1995, no laboratório de liquorologia da Fundação José Silveira. Foram selecionados 892 (12,7%) exames realizados em pacientes menores de 16 anos e com suspeita de meningite; entre os 139 casos de meningite bacteriana, H. influenzae tipo b foi o agente mais frequente (26,0%), ocorrendo em 100% das vezes em menores de 5 anos. Observou-se tendência na queda do número de casos de meningite por H. influenzae tipo b a partir de 1992. Questiona-se se este fato decorre do uso da vacina anti-H. influenzae tipo b nesta amostra da população.

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Etiologia de meningites bacterianas em uma amostra da população de Salvador - Bahia

Nascimento‐Carvalho

Moreno-Carvalho²

1998

Arq. Neuro-Psiquiatr.

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“…Substantial declines in invasive Haemophilus influenzae type b diseases have been reported in many countries where routine vaccination against H. influenzae type b has been implemented (3)(4)(5)(6). Although very successful in developed countries, H. influenzae type b vaccination is still very costly and unfeasible in the majority of developing countries.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial resistance patterns of Haemophilus influenzae isolated from patients with meningitis in São Paulo, Brazil

Casagrande

Vicente

Landgraf

et al. 2000

Braz J Med Biol Res

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From 1989 to 1995, a total of 391 Haemophilus influenzae isolates were recovered from the cerebrospinal fluid (CSF) of hospitalized patients in São Paulo, Brazil. The majority of strains were isolated from infants aged less than 5 years. Strains belonging to biotype I (64.7%), biotype II (34.5%) and biotype IV (0.76%) were detected. Ninety-nine percent of these strains were serotype b. Minimal inhibitory concentration (MIC) was determined for ampicillin, chloramphenicol and ceftriaxone. The ß-lactamase assay was performed for all strains. The rate of ß-lactamase producer strains ranged from 10 to 21.4% during a period of 7 years, with an overall rate of 13.8%. Of the 391 strains analyzed, none was ß-lactamase negative ampicillin resistant (BLNAR). A total of 9.7% of strains showed resistance to both ampicillin and chloramphenicol; however, 4% of them were resistant to ampicillin only and 2% to chloramphenicol. All strains were susceptible to ceftriaxone and the MIC 90 was 0.007 µg/ml, suggesting that ceftriaxone could be an option for the treatment of bacterial meningitis in pediatric patients who have not been screened for drug sensitivity.

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“…Various studies have described community settings where unvaccinated children show significant disease reduction, as a byproduct of vaccination of their peers [9,[60][61][62][63]. Intermittent colonization, however, is associated with development of natural immunity [64,65] and is likely the cause of the natural decline in incidence of invasive disease with age amongst unvaccinated children [66].…”

Section: Mechanism Of Vaccine Protectionmentioning

confidence: 99%

Haemophilus influenzae type b conjugate vaccines – A South African perspective

Visser

Hoosen

2012

Vaccine

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Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunisation with conjugate vaccines

Cited by 289 publications

References 20 publications

Etiologia de meningites bacterianas em uma amostra da população de Salvador - Bahia

Etiologia de meningites bacterianas em uma amostra da população de Salvador - Bahia

Antimicrobial resistance patterns of Haemophilus influenzae isolated from patients with meningitis in São Paulo, Brazil

Haemophilus influenzae type b conjugate vaccines – A South African perspective

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