Rapid determination of vitamin C by NIR, MIR and FT-Raman techniques

Abstract

Rapid spectroscopic determination of vitamin C in food and pharmaceutical products using infrared and Raman techniques was proposed. In this study, near-infrared (NIR), Fourier transform near-infrared (FT-NIR), Fourier transform infrared-attenuated total reflectance (FTIR-ATR), diffuse reflectance (DRIFTS), Fourier transform infrared-photoacoustic (FTIR-PAS) and FT-Raman spectroscopy were used in conjunction with partial least squares (PLS) regression to quantify vitamin C in powdered mixtures and solutions. Results indicate that the methods adopted have high prediction correlation. R2 values were 0.999 for FTIR-ATR, 0.976 for DRIFTS, 0.966 for FTIR-PAS, 0.988 for NIR, 0.992 for FT-NIR and 0.95 for FT-Raman, with an overall prediction error of 0.2-3.0%. The time required to complete an experiment ranged from 5 s (NIR) to 3 min (FT-Raman). The FTIR and FT-Raman techniques can be complementary tools for qualitative and quantitative characterization of the samples. Infrared and Raman techniques can be used to quantify vitamin C in foods and pharmaceutical products.

Identification and characterization of pharmaceuticals using Raman and surface‐enhanced Raman scattering

“…68 In this study, near-IR (NIR), Fourier transform (FT) NIR, FT IR-attenuated total reflectance (FTIR-ATR), diffuse reflectance (DRIFTS), FT IR-photoacoustic (FTIR-PAS) and FT-Raman spectroscopy were used in conjunction with partial least-squares (PLS) regression to quantify vitamin C in powders, mixtures and solutions. The results indicated that the methods adopted have high prediction correlation with an overall prediction error of 0.2-3.0%.…”

Determination of amoxicillin content in powdered pharmaceutical formulations using DRIFTS and PLS

“…Instrumentation analytical methods that are neither destructive nor produce residues have been increasingly investigated for the identification and quantification of active ingredients, using infrared spectroscopy (Blanco et al, 2000a;Blanco et al, 2000b;Blanco et al, 2001;Braga, Poppi, 2004;Pasquini, 2003;Sun, Xiang, An, 2004;Yang, Irudayaraj, 2002).…”

“…The interface between chemometric tools and the data obtained by infrared methods offers new possibilities for the quantification and qualification of pharmaceutical drugs (Blanco et al, 2000a;Blanco et al, 2000b;Blanco et al, 2001;Pasquini, 2003;Yang, Irudayaraj, 2002;Ferrão, Davanzo, 2005). On top of that, because it is a simple, easily obtained and non-destructive method, its procedures are appropriate for pharmaceutical formulations.…”

“…On top of that, because it is a simple, easily obtained and non-destructive method, its procedures are appropriate for pharmaceutical formulations. Such methods have allowed to compare (Sabin, Ferrão, Furtado, 2004;Neumann et al, 2004 and quantify (Blanco et al, 2000b;Blanco et al, 2001;Yang, Irudayaraj, 2002;Sun, Xiang, An, 2004;Konzen et al, 2003) several drugs during different manufacturing stages.…”

Aplicações da espectroscopia no infravermelho no controle de qualidade de medicamentos contendo diclofenaco de potássio. Parte I: dosagem por regressão multivariada

“…Associada ao crescente desenvolvimento do método de refletância difusa, este tipo de análise garante a caracterização de fármacos com extrema rapidez. A identificação destas substâncias pode ser alcançada tanto quantitativamente como qualitativamente através da espectroscopia por refletância difusa no infravermelho com transformada de Fourier (Diffuse Reflectance Infrared Fourier Transform Spectroscopy -DRIFTS) (Yang, Irudayaraj, 2002), aliada a ferramentas quimiométricas de análise multivariada (Neumann et al, 2004;Parisotto et al, 2005).…”