Rapid determination of scopolamine in evidence of recreational and predatory use

Sáiz, Jorge; Duc, Thanh; López, María López; Bartolomé, Carmen; Hauser, Peter C.; García-Ruiz, Carmen

doi:10.1016/j.scijus.2013.08.001

Cited by 52 publications

(39 citation statements)

References 33 publications

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“…A simple CE‐C 4 D method for determination of scopolamine and atropine, a related alkaloid, in seeds, drinks, and body lotions was presented by Sáiz et al. recently . Methanol poisonings are often reported as a consequence of ethanol adulteration by methanol and subsequent application of the toxic mixture in alcoholic beverages production.…”

Section: Applications Of Electrophoresis Methods With Conventional Camentioning

confidence: 99%

“… described an unmanned mobile platform employing CE‐C 4 D (called lab‐on‐a‐robot) for air sampling and analysis and demonstrated the determination of formic, acetic, and propionic acid vapors. Applications of portable CE‐C 4 D systems were further reported for the analysis of warfare degradation products , scopolamine in forensic studies , determination of inorganic and heavy metal ions in environmental samples , and the analysis of postblast residues . Portable CE‐C 4 D was also used as a scanning device for fraction collection prior to CE‐MALDI‐MS analyses of peptides .…”

Section: Instrumentationmentioning

confidence: 99%

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Contactless conductivity detection for analytical techniques—Developments from 2012 to 2014

Kubáň

Hauser

2014

Electrophoresis

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The review covers the progress of capacitively coupled contactless conductivity detection over the 2 years leading up to mid-2014. During this period many new applications for conventional CE as well as for microchip separation devices have been reported; prominent areas have been clinical, pharmaceutical, forensic, and food analyses. Further progress has been made in the development of field portable instrumentation based on CE with contactless conductivity detection. Several reports concern the combination with sample pretreatment techniques, in particular electrodriven extractions. Accounts of arrays of contactless conductivity detectors have appeared, which have been created for quite different tasks requiring spatially resolved information. The trend of the use of contactless conductivity measurements for applications other than CE has continued.

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Section: Applications Of Electrophoresis Methods With Conventional Camentioning

confidence: 99%

Section: Instrumentationmentioning

confidence: 99%

Contactless conductivity detection for analytical techniques—Developments from 2012 to 2014

Kubáň

Hauser

2014

Electrophoresis

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“…People have suffered intoxication looking for a recreational uses of this plant (Olivares, 1995). The toxicity of L. pubiflora is attributed to the high content of tropane alkaloids, mainly atropine and scopolamine, by competitive inhibition of muscarinic receptors (Defrates et al, 2005; Sáiz et al, 2013). Similar effects were observed with Datura compounds (Steenkamp et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

High Resolution UHPLC-MS Metabolomics and Sedative-Anxiolytic Effects of Latua pubiflora: A Mystic Plant used by Mapuche Amerindians

et al. 2017

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Latua pubiflora (Griseb) Phil. Is a native shrub of the Solanaceae family that grows freely in southern Chile and is employed among Mapuche aboriginals to induce sedative effects and hallucinations in religious or medicine rituals since prehispanic times. In this work, the pentobarbital-induced sleeping test and the elevated plus maze test were employed to test the behavioral effects of extracts of this plant in mice. The psychopharmacological evaluation of L. pubiflora extracts in mice determined that both alkaloid-enriched as well as the non-alkaloid extracts produced an increase of sleeping time and alteration of motor activity in mice at 150 mg/Kg. The alkaloid extract exhibited anxiolytic effects in the elevated plus maze test, which was counteracted by flumazenil. In addition, the alkaloid extract from L. pubiflora decreased [3H]-flunitrazepam binding on rat cortical membranes. In this study we have identified 18 tropane alkaloids (peaks 1–4, 8–13, 15–18, 21, 23, 24, and 28), 8 phenolic acids and related compounds (peaks 5–7, 14, 19, 20, 22, and 29) and 7 flavonoids (peaks 25–27 and 30–33) in extracts of L. pubiflora by UHPLC-PDA-MS which are responsible for the biological activity. This study assessed for the first time the sedative-anxiolytic effects of L. pubiflora in rats besides the high resolution metabolomics analysis including the finding of pharmacologically important tropane alkaloids and glycosylated flavonoids.

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“…The field of forensic analysis may also benefit from having systems available for fast analysis of suspicious samples. Sáiz et al focused their attention on scopolamine [18]. This alkaloid is clinically used, but also abused because of its influence on neurotransmission pathways concerning memory.…”

Section: Recent Applicationsmentioning

confidence: 99%

Recent Advances in Portable Analytical Electromigration Devices

Schepdael

2016

Separations

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Rapid determination of scopolamine in evidence of recreational and predatory use

Cited by 52 publications

References 33 publications

Contactless conductivity detection for analytical techniques—Developments from 2012 to 2014

Contactless conductivity detection for analytical techniques—Developments from 2012 to 2014

High Resolution UHPLC-MS Metabolomics and Sedative-Anxiolytic Effects of Latua pubiflora: A Mystic Plant used by Mapuche Amerindians

Recent Advances in Portable Analytical Electromigration Devices

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