Rapid determination of quinine in SA drinks by reversed phase ion pair chromatography

Jeuring, H. J.; Hoeven, W. van den.; Doorninck, P. van.; Broeke, Robert Ten

doi:10.1007/bf01193795

Cited by 14 publications

(3 citation statements)

References 4 publications

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“…8 Several methods have been reported for the determination of QnCl including spectrophotometry, [9][10][11] chromato-graphy [12][13][14][15] and fluorometry. 16 The present work describes new selective membrane electrodes of the conventional type, for the determination of QnCl in pure solution and in pharmaceuticals preparations.…”

Section: Introductionmentioning

confidence: 99%

Energy‐Dispersive and X‐Ray Photoelectron Spectroscopy and Electron Microscopy of New Quininium‐Plastic Membrane Electrodes

2007

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New quininium (Qn) plastic membrane electrodes of the conventional type were constructed and characterized. They are based on incorporation of Qn-reineckate (QnRn) ion-pair, Qn-phosphotungstate (Qn3-PT), or Qn-phosphomolybdate (Qn3PM) ion associate into a poly(vinyl chloride) membrane. The electrodes are selective for Qn and have been successfully used for the determination of Qn2SO4 in pharmaceutical tablets. Nevertheless, they showed, as almost all other ion-selective electrodes, limited life times. Energy dispersive- (EDS) and X-ray photoelectron spectroscopy (XPS), as well as electron microscopy were applied to investigate the cause of this limitation in the life times of the electrodes. The results indicated that the electrodes lose their activity after prolonged soaking as a result of leaching of the ion exchanger from the membranes into the test solution in addition to deformation at the surface of the expired electrode.

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Section: Introductionmentioning

confidence: 99%

Energy‐Dispersive and X‐Ray Photoelectron Spectroscopy and Electron Microscopy of New Quininium‐Plastic Membrane Electrodes

2007

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“…Chromatographic techniques, especially HPLC, have played the most important role in facilitating the detection and quantification of these compounds. Techniques used have included HPLC, [3][4][5][6][7] GC, 8 spectrophotometry, [9][10][11][12] fluorimetry, 13,14 immunoassay, 15,16 and chemiluminescence. 17 However, these methods suffer disadvantages, such as poor sensitivity, poor selectivity or a timeconsuming procedure.…”

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confidence: 99%

Optosensor for Cinchona Alkaloids With C18 Silica Gel as a Substrate

Gong¹,

Zhang²,

Yang³

1997

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A flow-through optosensor for cinchona alkaloids with C18 silica gel as a substrate is proposed. The sensor is developed in conjunction with a flow-injection analysis system and is based on the retention of the cinchona alkaloids on a C18 column and the enhancement of their fluorescence. The analytical performance characteristics of the proposed sensor for the detection and quantification of these alkaloids were as follows: the detection limits of quinine, cinchonine, quinidine and cinchonidine were 2.3, 31.6, 2.3 and 31.6 ng ml-1, respectively, with relative standard deviations of 0.9% for quinine and quinidine (20 ng ml-1, n = 7) and 1.1% for cinchonine and cinchonidine (4.0 micrograms ml-1, n =7), respectively. Most of the common species did not interfere. The recommended method has been successfully tested for determination of quinine in pharmaceutical preparations and soft drinks.

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“…Many analytical methods for the determination of quinine have been described, including direct [-4, 5] and indirect [1,6] spectrophotometric determination, highperformance liquid chromatographic [7][8][9], gas chromatography [10], fluorodensitometric measurement after separation by thin layer chromatography [11], fluorimetric method [12,13], and inmunoassay [14,15]. We have developed a 4th-order derivative spectrophotometry to determine quinine in soft drinks where colouring matter and other additives are also present.…”

mentioning

confidence: 99%