Rapid Determination of Monozygous Twinning with a Microfabricated Capillary Array Electrophoresis Genetic-Analysis Device1

Yeung, Stephanie H. I.; Medintz, Igor L.; Greenspoon, Susan A.; Mathies, Richard A.

doi:10.1373/clinchem.2007.102319

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…There are increasing successes in developing integrated, microfluidic, disposable diagnostic cards that still require instrumentation. 11,[33][34][35][36][37][38] Also, reports of disposable microfluidic devices with little or no instrumentation for POC diagnostics are appearing. 19,24,[39][40][41][42] One such report utilizes pressurized gas in a micro-reservoir as an energy source to control sequencing on a disposable card.…”

Section: Integrated Poc Microfluidic Devicesmentioning

confidence: 99%

Towards non- and minimally instrumented, microfluidics-based diagnostic devices

et al. 2008

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In many health care settings, it is uneconomical, impractical, or unaffordable to maintain and access a fully equipped diagnostics laboratory. Examples include home health care, developing-country health care, and emergency situations in which first responders are dealing with pandemics or biowarfare agent release. In those settings, fully disposable diagnostic devices that require no instrument support, reagent, or significant training are well suited. Although the only such technology to have found widespread adoption so far is the immunochromatographic rapid assay strip test, microfluidics holds promise to expand the range of assay technologies that can be performed in formats similar to that of a strip test. In this paper, we review progress toward development of disposable, low-cost, easy-to-use microfluidics-based diagnostics that require no instrument at all. We also present examples of microfluidic functional elements-including mixers, separators, and detectors-as well as complete microfluidic devices that function entirely without any moving parts and external power sources.

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Section: Integrated Poc Microfluidic Devicesmentioning

confidence: 99%

Towards non- and minimally instrumented, microfluidics-based diagnostic devices

et al. 2008

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“…Moreover, while reusable devices for continuous sample monitoring are highly desirable, many microfluidic devices are often designed to be disposable, again decreasing exposure risk. Finally, microfluidics offer a straightforward method for multiplexed detection, with the use of multiple parallel channels, along with demonstrated single-molecule analytical capabilities. ,− …”

Section: Spectroscopic Sensorsmentioning

confidence: 99%

“…The device could also be used to detect cholera toxin and the E. coli heat-labile toxin in water and meat samples. It is worth considering that electrophoretic devices are quite amenable to miniaturization while still being massively parallel and accommodating integrated sample preparation technologies. ,,− , …”

Section: Spectroscopic Sensorsmentioning

confidence: 99%

“…It is worth considering that electrophoretic devices are quite amenable to miniaturization while still being massively parallel and accommodating integrated sample preparation technologies. 104,115,[645][646][647]1130 ■ OUTLOOK AND PERSPECTIVE The focus of the preceding discussion has been to provide a wide cross-section of current diagnostics and, more importantly, recent research describing how biothreat agents are sensed along with some pertinent information on how they are classified and viewed from the perspective of public health officials. The continuing importance of this field is directly reflected in the depth and breadth of ongoing investment and the different research approaches currently being explored.…”

Section: ■ Spectroscopic Sensorsmentioning

confidence: 99%

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Detecting Biothreat Agents: From Current Diagnostics to Developing Sensor Technologies

et al. 2018

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Although a fundamental understanding of the pathogenicity of most biothreat agents has been elucidated and available treatments have increased substantially over the past decades, they still represent a significant public health threat in this age of (bio)terrorism, indiscriminate warfare, pollution, climate change, unchecked population growth, and globalization. The key step to almost all prevention, protection, prophylaxis, post-exposure treatment, and mitigation of any bioagent is early detection. Here, we review available methods for detecting bioagents including pathogenic bacteria and viruses along with their toxins. An introduction placing this subject in the historical context of previous naturally occurring outbreaks and efforts to weaponize selected agents is first provided along with definitions and relevant considerations. An overview of the detection technologies that find use in this endeavor along with how they provide data or transduce signal within a sensing configuration follows. Current "gold" standards for biothreat detection/diagnostics along with a listing of relevant FDA approved in vitro diagnostic devices is then discussed to provide an overview of the current state of the art. Given the 2014 outbreak of Ebola virus in Western Africa and the recent 2016 spread of Zika virus in the Americas, discussion of what constitutes a public health emergency and how new in vitro diagnostic devices are authorized for emergency use in the U.S. are also included. The majority of the Review is then subdivided around the sensing of bacterial, viral, and toxin biothreats with each including an overview of the major agents in that class, a detailed cross-section of different sensing methods in development based on assay format or analytical technique, and some discussion of related microfluidic lab-on-a-chip/point-of-care devices. Finally, an outlook is given on how this field will develop from the perspective of the biosensing technology itself and the new emerging threats they may face.

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Utilizing the Organizational Power of DNA Scaffolds for New Nanophotonic Applications

Bui

Dı́az

Fontana

et al. 2019

Advanced Optical Materials

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Rapid development of DNA technology has provided a feasible route to creating nanoscale materials. DNA acts as a self‐assembled nanoscaffold capable of assuming any three‐dimensional shape. The ability to integrate dyes and new optical materials such as quantum dots and plasmonic nanoparticles precisely onto these architectures provides new ways to exploit their near‐ and far‐field interactions. A fundamental understanding of these optical processes will help drive development of next‐generation photonic nanomaterials. This review is focused on latest progress in DNA‐based photonic materials and highlights DNA scaffolds for rapidly assembling and prototyping nanoscale optical devices. Three areas are discussed including intrinsically active DNA structures displaying chiral properties, DNA scaffolds hosting plasmonic nanomaterials, and fluorophore‐labeled DNAs that engage in Förster resonance energy transfer and give rise to complex molecular photonic wires. An explanation of what is desired from these optical processes when harnessed sets the tone for what DNA scaffolds are providing toward each focus. Examples from the literature illustrate current progress along with a discussion of challenges to overcome for further improvements. Opportunities to integrate diverse classes of optically active molecules including light‐generating enzymes, fluorescent proteins, nanoclusters, and metal–chelates in new structural combinations on DNA scaffolds are also highlighted.

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Rapid Determination of Monozygous Twinning with a Microfabricated Capillary Array Electrophoresis Genetic-Analysis Device1

Cited by 7 publications

References 19 publications

Towards non- and minimally instrumented, microfluidics-based diagnostic devices

Towards non- and minimally instrumented, microfluidics-based diagnostic devices

Detecting Biothreat Agents: From Current Diagnostics to Developing Sensor Technologies

Utilizing the Organizational Power of DNA Scaffolds for New Nanophotonic Applications

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