Rapid determination of clindamycin in medicine with myoglobin–luminol chemiluminescence system

Shao, Xiaodong; Xie, Xiaofeng; Liu, Yanhong; Song, Zhengyong

doi:10.1016/j.jpba.2005.12.027

Cited by 17 publications

(8 citation statements)

References 16 publications

(15 reference statements)

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“…Compared with these techniques, the combination of CL and a flow-injection (FI) method (FI-CL) provides many advantages for pharmaceutical analyses, such as high sensitivity, high selectivity, small chemical consumption, cost effectiveness and simple sample preparation and instrumentation (17,18), and has been frequently used for this purpose in recent years (19). The use of FI-CL for the determination of clindamycin is based on the inhibitory effect of clindamycin on the reaction between luminol and myoglobin (20).…”

Section: Clindamycin [7(s)-chloro-7-deoxylincomycin] Is An Antibioticmentioning

confidence: 99%

Ultrasensitive assay of clindamycin in medicine and bio‐fluids with chemiluminescence detection

Wei

Dang

2007

Luminescence

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A simple chemiluminescence (CL) method using flow injection has been developed for the determination of clindamycin, based on the inhibitory effect of clindamycin on the CL generated from the luminol-K(3)Fe(CN)(6) system in alkaline medium. It was found that the decrement of CL intensity was linear with the logarithm of clindamycin concentration over the range 0.7-1000 ng/mL. The detection limit was 0.2 ng/mL with a relative standard deviation (RSD) of <5.0% (n = 7). At a flow rate of 3.0 mL/min, a complete analytical process could be performed within 0.5 min, including sampling and washing. The proposed procedure was applied successfully to the determination of clindamycin in pharmaceutical preparations and human urine without pretreatment.

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Section: Clindamycin [7(s)-chloro-7-deoxylincomycin] Is An Antibioticmentioning

confidence: 99%

Ultrasensitive assay of clindamycin in medicine and bio‐fluids with chemiluminescence detection

Wei

Dang

2007

Luminescence

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“…Currently, the detection methods of clindamycin mainly include chemiluminescence, 5 high-performance liquid chromatography-mass spectrometry (HPLC-MS), 6 high-performance liquid chromatography (HPLC), 7 gas−liquid chromatography method (GLC), 8 capillary electrophoresis (CE), 9 microbiological analysis method, 10 adsorption voltammetry, 11 and so on. Although all of the abovementioned methods can be used for the determination of clindamycin, unfortunately, there are also some shortcomings.…”

Section: ■ Introductionmentioning

confidence: 99%

Visual Recognition and Detection of Clindamycin by Au@Ag Core–Shell Nanoparticles

Jing

et al. 2021

ACS Omega

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The work described a new colorimetric sensor for the quantitative detection of clindamycin based on Au@Ag core–shell nanoparticles (Au@Ag NPs). The obtained Au@Ag NPs were characterized by transmission electron microscopy (TEM) and ultraviolet and visible spectrophotometry (UV–vis). When Au@Ag NPs were added to a clindamycin solution, it can be observed that the color immediately changed from bright yellow to gray-blue and the absorption spectrum also changed, realizing the visual detection of clindamycin. Under optimal conditions, the absorption ratio (A 546/A 400) of the UV–vis spectra increased linearly with the concentration of clindamycin ranging from 6.25 × 10–7 to 7.50 × 10–6 mol/L (R 2 = 0.9945), with a limit of detection (LOD) of 2.00 × 10–7 mol/L and good recovery of 100.0–102.0% (relative standard deviation (RSD) < 2%). The detection process was convenient without complicated instruments. Compared with other analytes, the Au@Ag NPs detection system has good selectivity for clindamycin. In addition, the Au@Ag NPs colorimetric sensor was successfully used to determine clindamycin in human urine samples. This study provides a simple, rapid, intuitive, and low-cost visualization analysis method of clindamycin, which was helpful for the visualization detection of other targets.

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“…High-performance liquid chromatography (HPLC) is the most commonly used [2,[4][5][6][7][8][9], potentiometric determination [10] capillary electrophoresis [11], micellar chromatography [12], chemiluminescence methods [13], voltammetry [14][15][16] and Spectrophotometric determination that dependent on color forming [17][18].…”

Section: Introductionmentioning

confidence: 99%

Determination of CLINDAMYCIN HCl in Capsules by New, Validated, Simple and Green Kinetic Spectrometric Method

Affas¹,

Sakur

2021

Preprint

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Background: simple, sensitive, free of organic solvents, kinetic spectrophotometric method has been developed for the determination of Clindamycin Hydrochloride, both in pure form and Capsules. Method used is based on reaction of Clindamycin with potassium iodide and potassium iodate in aqueous medium at (25 ±2 °c) to produce yellow colored tri iodide ions (I3-). the reaction is followed spectrophotometrically by measuring the absorbance at 350 nm wavelength during 40 minutes. Results: the effects of analytical parameters on reported kinetic methods were investigated. Under the optimized conditions, the initial rate and fixed time (at 10 min) methods were used for constructing the calibration graphs. The graphs were linear in concentration ranges 1-20 μg.ml-1 with limit of detection of 0.12 and 0.22 μg ml-1for the initial rate and fixed time methods, respectively. The results were satisfactory and the analytical performance for both methods was validated. Conclusion: The proposed methods have been applied to determine the components in capsules with an average recovery of 98.25% to 102.00% and the results are in good agreement with those found by the reference method.

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Rapid determination of clindamycin in medicine with myoglobin–luminol chemiluminescence system

Cited by 17 publications

References 16 publications

Ultrasensitive assay of clindamycin in medicine and bio‐fluids with chemiluminescence detection

Ultrasensitive assay of clindamycin in medicine and bio‐fluids with chemiluminescence detection

Visual Recognition and Detection of Clindamycin by Au@Ag Core–Shell Nanoparticles

Determination of CLINDAMYCIN HCl in Capsules by New, Validated, Simple and Green Kinetic Spectrometric Method

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