Rapid determination of acyclovir in edible creatural tissues by molecularly imprinted matrix solid-phase dispersion coupled with high performance liquid chromatography

Han, Yehong; Yan, Hongyuan; Cheng, Xiaoling; Yang, Gengliang; Li, Baohui

doi:10.1039/c3ay40170g

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…The results indicated a good linear calibration (R 2 = 0.9994) and an acceptable range of mean recovery (91.6-103%) for ACV. Alongside, Han et al [99] prepared the molecularly imprinted matrix solid-phase dispersion (MI-MSPD) by using templates of theophyllines, functional monomers of MAA, a cross-linking agent of EGDMA and an initiator of AIBN. A simple, rapid and selective method, which applied MI-MSPD coupled with HPLC (MI-MSPD-HPLC), was proposed for analyzing ACV in creatural tissues.…”

Section: Molecularly Imprinted Polymers (Mips)mentioning

confidence: 99%

Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Wei

Yao

et al. 2021

Molecules

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Acyclovir (ACV) is an effective and selective antiviral drug, and the study of its toxicology and the use of appropriate detection techniques to control its toxicity at safe levels are extremely important for medicine efforts and human health. This review discusses the mechanism driving ACV’s ability to inhibit viral coding, starting from its development and pharmacology. A comprehensive summary of the existing preparation methods and synthetic materials, such as 5-aminoimidazole-4-carboxamide, guanine and its derivatives, and other purine derivatives, is presented to elucidate the preparation of ACV in detail. In addition, it presents valuable analytical procedures for the toxicological studies of ACV, which are essential for human use and dosing. Analytical methods, including spectrophotometry, high performance liquid chromatography (HPLC), liquid chromatography/tandem mass spectrometry (LC-MS/MS), electrochemical sensors, molecularly imprinted polymers (MIPs), and flow injection–chemiluminescence (FI-CL) are also highlighted. A brief description of the characteristics of each of these methods is also presented. Finally, insight is provided for the development of ACV to drive further innovation of ACV in pharmaceutical applications. This review provides a comprehensive summary of the past life and future challenges of ACV.

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Section: Molecularly Imprinted Polymers (Mips)mentioning

confidence: 99%

Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Wei

Yao

et al. 2021

Molecules

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“…In this study, an MISPE with thiamphenicol as the template molecule was developed and optimized by chromatographic methods for specific, simultaneous, qualitative, and quantitative analyses of chloramphenicol, thiamphenicol florfenicol, and florfenicol amine in aquaculture samples coupled with liquid chromatography–mass spectrometry/mass spectrometry (LC–MS/MS). The significant progress of MIPs in SPE and SPME in food analyses is summarized in Table , …”

Section: Highlighted Applications Of Mips In Food Analysismentioning

confidence: 99%

Recent advances in molecularly imprinted polymers in food analysis

Song

Chen

et al. 2014

J of Applied Polymer Sci

104

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Food security as a world issue has received increasing concern, and therefore, effective analytical methods and technologies have been continuously developed. However, the matrix complexity of food samples and the trace/ultratrace presence of targeted analytes require highly efficient cleanup and enrichment materials and procedures. Molecularly imprinted polymers (MIPs) with specific recognition abilities as versatile materials are being increasingly developed for diverse species in various fields, especially in food analysis. In this review, we mainly summarize the recent advances in MIPs used for food matrices over the last 5 years. We focus on toxic and harmful substances, such as pesticide/drug residues, heavy metals, microbial toxins, and additives. Some relatively new preparation methods involving surface imprinting, composites, and stimuli responsiveness are reviewed. Different MIPs as solid-phase adsorbents in solid-phase extraction, solid-phase microextraction, matrix solid-phase dispersion, stirring bar sorptive extraction, and magnetic material extraction and as stationary phases in chromatographic separation for foodstuff have been comprehensively summarized. MIP-based biomimetic sensing and enzymelike catalysis receive special attention. Moreover, some limitations and comparisons related to MIPs performances are also discussed. Finally, some significant attempts to further promote MIP properties and applications to ensure food safety are discussed.

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“…Figure (1). The chemical structure of acyclovir (ACV) ACV has been determined in pure form, dosage forms, and biological fluids using a variety of analytical methods, including chromatography [3][4][5][6], electrochemistry [7][8][9][10], spectrofluorimetry [11][12][13], flow injection [14], FT-IR [15], and spectrophotometry [13,[16][17][18][19][20][21][22][23][24][25][26][27][28][29]. The depicted analytical techniques that have been reported for the determination of ACV appear to depend on the use of a practical instrument for the majority of these techniques.…”

Section: Introductionmentioning

confidence: 99%

“…Figure(6). Application of Job's method to the reaction between ACV and Quinz and ARS reagents.from VAL and Quinz reaction.…”

mentioning

confidence: 99%

Utilization of charge transfer complexation reaction for the spectrophotometric determination of acyclovir as antiviral drug in pharmaceutical formulations

Gouda,

elsheikh,

Mahmoud

et al. 2024

Bulletin of Faculty of Science, Zagazig University

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The present work aims to develop and validate two simple, sensitive, accurate, precise and economical spectrophotometric methods for the determination of acyclovir (ACV) in pure form and pharmaceutical formulations. The developed methods are based on the formation of charge transfer complex between VAL as n-electron donor and quinalizarin (Quinz) or alizarin red S (ARS) as π-acceptor in methanol to form highly colored chromogens which showed an absorption maximum at 560 and 538 nm using Quinz and ARS, respectively. The optimization of the reaction conditions such as the type of solvent, reagent concentration and reaction time were investigated. Under the optimum conditions, Beer's law is obeyed in the concentration ranges 1.0-20 and 1.0-24 μg/ml using Quinz and ARS, respectively with good correlation coefficient (r 2 ≥ 0.9994) and with a relative standard deviation (RSD% ≤ 0.80). The limits of detection and quantificationwere found to be 0.30 and 1.0 µg/ml for Quinz and 0.29 and 0.97 µg/mL for ARS. The methods were successfully applied to the determination of VAL in its pharmaceutical formulations and the validity assesses by applying the standard addition technique. Results obtained by the proposed methods for the pure VAL and commercial tablets agreed well with those obtained by the reported method.

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Rapid determination of acyclovir in edible creatural tissues by molecularly imprinted matrix solid-phase dispersion coupled with high performance liquid chromatography

Cited by 8 publications

References 26 publications

Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Recent advances in molecularly imprinted polymers in food analysis

Utilization of charge transfer complexation reaction for the spectrophotometric determination of acyclovir as antiviral drug in pharmaceutical formulations

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