Rapid determination of 90Sr impurities in freshly “generator eluted” 90Y for radiopharmaceutical preparation

Radiometals for imaging and theranostics, current production, and future perspectives

“…In order to prove that the 90 Y is suitable for medical application, it is desirable to selectively separate 90 Sr from all possible impurities, including its short‐lived 90 Y daughter. Several separation methods have been reported for the purpose of fast determination of 90 Sr in 90 Y …”

“…Several separation methods have been reported for the purpose of fast determination of 90 Sr in 90 Y. [64][65][66] 3.4 | 186/188 Re The chemical similarity between technetium and rhenium has attracted the attention of researchers to design the therapeutic radiopharmaceuticals utilizing the potential of Re radionuclides. 67 The transition metal chemistry of n.c.a.…”

“…As a result, automated purification systems for use towards clinical trials have been investigated. 112,113 3.7 | 61/64/67 Cu Both 61 Cu (T 1/2 = 3.4 h) and 64 Cu (T 1/2 = 12.7 h) have been widely used for the radiolabelling of peptides, antibodies, and antibody fragments. These radionuclides have also been suggested as diagnostic isotope partners to the therapeutic 67 Cu.…”

“…As copper plays significant biological roles in vivo, care must be taken to prevent dissociation of the radiopharmaceutical complexes, and thus, much research has been conducted on novel chelators for Cu radioisotopes. 114 Production techniques for 61,64 Cu are well developed and typically make use of the 61 Ni(p,n) 61 Cu and 64 Ni(p, n) 64 Cu reactions. 115,116 Gold or silver target backings are electroplated with enriched Ni target material from electroplating baths composed of nickel sulfate or nickel chloride.…”

“…117 After irradiation, the target material is dissolved in HCl and transferred to an ion exchange column. The nickel target material is recovered in the high molarity HCl, while the 61,64 Cu is eluted in weak acid or water. Typically, a mid-range HCl concentration is used to elute coproduced 61 Co (T 1/2 = 1.65 h), which is produced via the 64 Ni(p,α) 61 Co reaction.…”