Rapid detection of nicotine from breath using desorption ionisation on porous silicon

Guinan, Taryn; Abdelmaksoud, Hazem H.; Voelcker, Nicolas H.

doi:10.1039/c7cc00243b

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…[108] Apart from routine validation, SALDI-MS technique gained increasing attention in drug detection, quantitation, screening, compliance, and metal-drug interaction study. [109][110][111][112][113][114] Liu et al prepared antibody-GO nanoribbons for the enrichment and determination of chloramphenicol in river water and human serum samples with a limit detection of 10 pg mL -1 . [109] GO nanoribbons are low-defect graphene materials with higher water dispersibility, the monodisperse geometry makes them easy to be modified homogenously and produces reproducible analytical results.…”

Section: Small Moleculesmentioning

confidence: 99%

“…Apart from routine validation, SALDI‐MS technique gained increasing attention in drug detection, quantitation, screening, compliance, and metal‐drug interaction study. [ 109–114 ] Liu et al. prepared antibody‐GO nanoribbons for the enrichment and determination of chloramphenicol in river water and human serum samples with a limit detection of 10 pg mL –1 .…”

Section: Applications Of Saldi‐ms In Biomedical Analysismentioning

confidence: 99%

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Nanostructured Substrates as Matrices for Surface Assisted Laser Desorption/Ionization Mass Spectrometry: A Progress Report from Material Research to Biomedical Applications

et al. 2021

Small Methods

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Section: Small Moleculesmentioning

confidence: 99%

Section: Applications Of Saldi‐ms In Biomedical Analysismentioning

confidence: 99%

Nanostructured Substrates as Matrices for Surface Assisted Laser Desorption/Ionization Mass Spectrometry: A Progress Report from Material Research to Biomedical Applications

et al. 2021

Small Methods

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“…Nonbiofluid sample types include exhaled breath [40], hair [41], nails [42], skin [43] and tissue [44]. MALDI-MS imaging is becoming increasingly useful to study solid sample matrices such as tissue for diagnosis, especially from cancerous biopsies.…”

Section: Sample and Type Of Analytesmentioning

confidence: 99%

Matrix-assisted laser desorption ionisation (MALDI) mass spectrometry (MS): basics and clinical applications

Israr

Bernieh

Salzano

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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AbstractBackgroundMatrix-assisted laser desorption ionisation (MALDI) mass spectrometry (MS) has been used for more than 30 years. Compared with other analytical techniques, it offers ease of use, high throughput, robustness, cost-effectiveness, rapid analysis and sensitivity. As advantages, current clinical techniques (e.g. immunoassays) are unable to directly measure the biomarker; rather, they measure secondary signals. MALDI-MS has been extensively researched for clinical applications, and it is set for a breakthrough as a routine tool for clinical diagnostics.ContentThis review reports on the principles of MALDI-MS and discusses current clinical applications and the future clinical prospects for MALDI-MS. Furthermore, the review assesses the limitations currently experienced in clinical assays, the advantages and the impact of MALDI-MS to transform clinical laboratories.SummaryMALDI-MS is widely used in clinical microbiology for the screening of microbial isolates; however, there is scope to apply MALDI-MS in the diagnosis, prognosis, therapeutic drug monitoring and biopsy imaging in many diseases.OutlookThere is considerable potential for MALDI-MS in clinic as a tool for screening, profiling and imaging because of its high sensitivity and specificity over alternative techniques.

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“…In particular, functionalized PSi can be fabricated into multiple sensors. Rapid desorption of nicotine from respiratory gas has been achieved by analytical ionization on the porous silicon surface [ 3 ]. Metal (Ni and Bi) coatings on the PSi nanostructure surface were prepared for high capacity and the stable performance anode material lithium ion battery [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Metal Nanoparticles/Porous Silicon Microcavity Enhanced Surface Plasmon Resonance Fluorescence for the Detection of DNA

Wang

Jia

2018

Sensors

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A porous silicon microcavity (PSiMC) with resonant peak wavelength of 635 nm was fabricated by electrochemical etching. Metal nanoparticles (NPs)/PSiMC enhanced fluorescence substrates were prepared by the electrostatic adherence of Au NPs that were distributed in PSiMC. The Au NPs/PSiMC device was used to characterize the target DNA immobilization and hybridization with its complementary DNA sequences marked with Rhodamine red (RRA). Fluorescence enhancement was observed on the Au NPs/PSiMC device substrate; and the minimum detection concentration of DNA ran up to 10 pM. The surface plasmon resonance (SPR) of the MC substrate; which is so well-positioned to improve fluorescence enhancement rather the fluorescence enhancement of the high reflection band of the Bragg reflector; would welcome such a highly sensitive in biosensor.

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Rapid detection of nicotine from breath using desorption ionisation on porous silicon

Abstract: Desorption ionisation on porous silicon mass spectrometry was used for the detection of nicotine from exhaled breath.

Cited by 9 publications

References 26 publications

Nanostructured Substrates as Matrices for Surface Assisted Laser Desorption/Ionization Mass Spectrometry: A Progress Report from Material Research to Biomedical Applications

Nanostructured Substrates as Matrices for Surface Assisted Laser Desorption/Ionization Mass Spectrometry: A Progress Report from Material Research to Biomedical Applications

Matrix-assisted laser desorption ionisation (MALDI) mass spectrometry (MS): basics and clinical applications

Metal Nanoparticles/Porous Silicon Microcavity Enhanced Surface Plasmon Resonance Fluorescence for the Detection of DNA

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