Rapid detection of alteration of serum IgG in patients with schizophrenia after risperidone treatment by matrix‐assisted laser desorption ionization/time‐of‐flight mass spectrometry

Lo, Li‐Hua; Shiea, Jentaie; Huang, Tiao‐Lai

doi:10.1002/rcm.7753

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…During 6 months of risperidone treatment (2-6 mg/day), TNF-α levels increased compared with baseline while IL-1β and IL-6 decreased at 1 month and then gradually increased at the end of the follow-up (154). In ASD patients, eotaxin and monocyte chemoattractant protein-1 (MCP-1) levels significantly decreased after 8 weeks of treatment (0.5-1.5 mg/day) (177). Regarding Igs, a report showed that a 4-week treatment with risperidone increased Igγ (IgG) chain levels significantly when compared with baseline (178).…”

Section: Risperidonementioning

confidence: 99%

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

et al. 2020

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Atypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for other psychiatric conditions in clinical practice such as affective disorders and autism spectrum disorder, among others. These drugs are differentiated from typical antipsychotics based on their clinical profile and are a better choice because they cause fewer side effects regarding extrapyramidal symptoms (EPS). Even though they provide clear therapeutic benefits, AAP induce peripheral effects that trigger phenotypic, functional, and systemic changes outside the Central Nervous System (CNS). Metabolic disease is frequently associated with AAP and significantly impacts the patient's quality of life. However, other peripheral changes of clinical relevance are present during AAP treatment, such as alterations in the immune and endocrine systems as well as the intestinal microbiome. These less studied alterations also have a significant impact in the patient's health status. This manuscript aims to revise the peripheral immunological, endocrine, and intestinal microbiome changes induced by AAP consumption recommended in the clinical guidelines for schizophrenia and other psychiatric disorders.

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Section: Risperidonementioning

confidence: 99%

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

et al. 2020

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“…Yet another report described a decreased IgD levels in BD [ 35 ]. Studies focusing on SZ revealed an elevation of IgA, IgM or IgG in the patients’ sera or CSF during acute phases of the disease ([ 1 , 3 , 6 , 10 , 11 , 16 , 27 , 29 , 32 ]). Interestingly, in SZ, IgG raises gradually to reach a peak at about 12 to 17 years after the onset typically mirroring persistence of an underlying infection [ 10 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin sub-class distribution in bipolar disorder and schizophrenia: potential relationship with latent Toxoplasma Gondii infection

et al. 2018

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BackgroundImmune dysfunction could play a significant role in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ), conditions with an underlying pro-inflammatory state. Studies on humoral immune responses (which reflects antibody mediated fight against pathogens) in schizophrenia and bipolar disorder are sparse and often providing contradictory results. The aim of this study was to assess humoral immunity in a group of stable bipolar disorder and schizophrenia patients compared to controls by determining total Immunoglobulins and IgG subclasses and to assess their association with latent Toxoplasma gondii and/or CMV infection.Methods334 subjects (124 BD, 75 SZ and 135 Healthy Controls [HC]) were included and tested for humoral immunity by determining the total immunoglobulins (IgG,A and M) and IgG subclasses (IgG1, IgG2, IgG3, IgG4) and their relationship with latent Toxoplasma gondii infection, an established risk factor for BD and SZ.ResultsAlthough lower levels of IgG, IgG1, IgG2, IgG4 and IgA were found among BD as compared to HC and/or SZ, after adjustment for confounding variables, only low levels of IgG and IgG1 in BD remai- ned significant. Strikingly highest levels of antibodies to T. gondii (but not CMV) infection in BD and SZ were associated with lowest levels of IgG3 and IgG4 levels as compared to controls.ConclusionsSchizophrenia and bipolar disorder patients with latent T. gondii specific infection may be more vulnerable to changes in immuno-inflammatory processes than controls with similar latent infectious state. Simultaneous sequential immunological monitoring both in steady state and active disease phases in the same BD and SZ patients are warranted to understand the role of Toxoplasma gondii latency in these disorders.

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“…In another study, trifluoroacetic acid was used to effectively hydrolyze albumin, and a decrease was observed in the ion ratio of transferrin to fibrinogen fragments in the sera of patients diagnosed with acute-phase mental disorders [ 20 ]. Another analytical strategy involving strong acid hydrolysis followed by off-line HPLC coupled with MALDI-TOF analysis was able to characterize serum IgG levels in schizophrenia patients before and after risperidone treatment [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Potential Protein Biomarkers for Major Depressive Disorder Using Matrix-Assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry

Lin

Hung

et al. 2021

Molecules

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Matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry is a sensitive analytical tool for characterizing various biomolecules in biofluids. In this study, MALDI-TOF was used to characterize potential plasma biomarkers for distinguishing patients with major depressive disorder (MDD) from patients with schizophrenia and healthy controls. To avoid interference from albumin—the predominant protein in plasma—the plasma samples were pretreated using acid hydrolysis. The results obtained by MALDI-TOF were also validated by electrospray ionization-quadrupole time-of-flight (ESI-QTOF) mass spectrometry. The analytical results were further treated with principal component analysis (PCA), hierarchical clustering analysis (HCA), and receiver operating characteristic (ROC) curve analysis. The statistical analyses showed that MDD patients could be distinguished from schizophrenia patients and healthy controls by the lack of apolipoprotein C1 (Apo C1), which, in fact, was detected in healthy controls and schizophrenia patients. This protein is suggested to be a potential plasma biomarker for distinguishing MDD patients from healthy controls and schizophrenia patients. Since sample preparation for MALDI-TOF is very simple, high-throughput plasma apolipoprotein analysis for clinical purposes is feasible.

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Rapid detection of alteration of serum IgG in patients with schizophrenia after risperidone treatment by matrix‐assisted laser desorption ionization/time‐of‐flight mass spectrometry

Cited by 9 publications

References 43 publications

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

Immunoglobulin sub-class distribution in bipolar disorder and schizophrenia: potential relationship with latent Toxoplasma Gondii infection

Characterization of Potential Protein Biomarkers for Major Depressive Disorder Using Matrix-Assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry

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