Rapid detection of airborne protein from Mycobacterium tuberculosis using a biosensor detection system

Abstract

Tuberculosis (TB) caused by infection with airborne Mycobacterium tuberculosis (MTB) seriously threatens human health and has become a public health problem of worldwide concern. To achieve effective control of TB,...

A self-contained and integrated microfluidic nano-detection system for the biosensing and analysis of molecular interactions

“…The conventional electrical signal detection equipment, Keithley 2400 semiconductor parameter analyzer (Keithley Instruments Inc., OH, USA), despite its high sensitivity and accuracy, can only be obtained through manual user judgment based on common sense. 24…”

“…At present, SiNW-FET biosensors often require discrete detection components that have not yet been implemented in integrated and mobile devices in actual detection. 18,24 Furthermore, because the surfaces of SiNW-FET biosensors are inevitably exposed to the external environment, they are susceptible to interference. They are extremely sensitive to external environmental factors such as temperature, light and pH, which may cause detection errors.…”

“…The conventional electrical signal detection equipment, Keithley 2400 semiconductor parameter analyzer (Keithley Instruments Inc., OH, USA), despite its high sensitivity and accuracy, can only be obtained through manual user judgment based on common sense. 24 Due to the non-contact characteristic of the light response measurements, the light calibration method has the advantage of not polluting the SiNW-FET sensor. 25 Thus, light modulation was used to improve the uniformity of the SiNW-FET biosensor.…”

Detection of SARS-COV-2 by functionally imprinted micelles

“…Near real-time detection of airborne pathogens is needed to control current and avoid future pandemics. [1][2][3][4][5][6] Described herein is a system that was developed for the near real-time detection of ambient liquid severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) samples, with the demonstration of coupling to airborne sampling. The ability to detect SARS-COV-2 or other pathogens in near real time would allow rapid screening and potential early detection of virus spread.…”

“…[16] To advance imprinting technology to be field-deployable, we have focused on the functionalization of the imprinted technology to produce a signal that can be detected by commercial electronic systems. [1][2][3][4][5][6] Micelles [17] in an electrochemical cell can produce measurable electronic signals when they change morphology. [18,19] The electronic signals from the micelles can be read as changes in the properties of the bulk liquid.…”