Rapid Declines in Age Group–Specific Rotavirus Infection and Acute Gastroenteritis Among Vaccinated and Unvaccinated Individuals Within 1 Year of Rotavirus Vaccine Introduction in England and Wales

Atchison, Christina; Stowe, Julia; Andrews, Nick; Collins, Sarah; Allen, David J.; Nawaz, Sameena; Brown, David; Ramsay, Mary; Ladhani, Shamez

doi:10.1093/infdis/jiv398

Cited by 78 publications

(59 citation statements)

References 25 publications

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“…The results were in contrast to those of previous reports from the US and UK describing a rapid decline in older (≥5 years) populations after RV vaccines were introduced in the national immunization program. 14,17 Although it is apparent that most children in this age group would have remained unvaccinated as they were over the eligible age for vaccination, this was also the same case for previous studies from the US and UK. Thus, it is possible that vaccination coverage in the applicable age group in Japan might have been insufficient to provide a detectable indirect effect on the older age group.…”

Section: Discussionsupporting

confidence: 59%

Sustained reduction in rotavirus-coded hospitalizations in children aged <5 years after introduction of self-financed rotavirus vaccines in Japan

Kobayashi

Miyazaki

Tatsumi³

2019

Human Vaccines & Immunotherapeutics

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This is an extension of our previous study, which evaluated the incidence of seasonal rotavirus gastroenteritis (RVGE) hospitalizations in children aged <5 years from 2009 to 2015 in Japan. Here, we evaluated the incidence of RVGE hospitalizations in children aged <10 years during the rotavirus season (January-June) from 2009 to 2017 in Japan, before and after the monovalent and pentavalent rotavirus vaccines were introduced in November 2011 and July 2012, using the same health insurance claims database and study methods. In children aged <5 years, the incidence of RVGE hospitalizations greatly declined in 2014 after vaccine introduction, consistent with our previous findings, and the decline was sustained until 2017. However, in children aged ≥5-<10 years, no apparent trend for a continuous decline in RVGE hospitalizations was observed during the study period. Improved RV vaccination coverage may lead to a further reduction in severe RVGE in Japan.

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Section: Discussionsupporting

confidence: 59%

Sustained reduction in rotavirus-coded hospitalizations in children aged <5 years after introduction of self-financed rotavirus vaccines in Japan

Kobayashi

Miyazaki

Tatsumi³

2019

Human Vaccines & Immunotherapeutics

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“…Several studies have indicated that rotavirus vaccination programs are a high‐impact intervention for public health [Vesikari et al, ; Leshem et al, ; Paternina‐Caicedo et al, ; Atchison et al, ]. Specifically, in every Latin American and the Caribbean country where rotavirus vaccine was massively introduced, reduction of the severity and cases of death related to this agent was observed [Molto et al, ; Patel et al, ; Rha et al, ; de Oliveira et al, ; Paternina‐Caicedo et al, ; Teles et al, ].…”

Section: Discussionmentioning

confidence: 99%

Rotavirus epidemiology and surveillance before vaccine introduction in Argentina, 2012–2014

Degiuseppe

Reale

Stupka

2016

Journal of Medical Virology

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Group A Rotavirus has been widely described as one of the most important infantile diarrheal pathogens worldwide. In Argentina, it is responsible for over 200,000 acute diarrhea cases and from 30 to 50 deaths annually in children under 5 years. The aim of this study is to analyze frequency, seasonality, age group distribution, and circulating genotypes based on data notified in the 2012-2014 period and in turn to assess the pre-vaccine scenario, considering that rotavirus vaccine was introduced in 2015. Data were taken from the Viral Diarrhea Notification module of the Argentine SNVS-SIVILA surveillance tool. Analyses of circulating genotypes were performed on rotavirus-positive stool specimens by conventional binary characterization of the outermost capsid genes. Overall data showed rotavirus detection in about 25% of samples tested, and higher rates in children under 2 years old were observed. Rotavirus positive cases were distributed according to a typical winter seasonal pattern. A heterogeneous regional pattern of prevalence was also observed, with higher rates detected in the North region. Genotype co-circulation and annual fluctuation were observed. In general, G1P[8], G2P[4], G3P[8], and G12P[8] were the most frequently detected genotypes. This study represents the last survey taken of a population considered to be naïve. J. Med. Virol. 89:423-428, 2017. © 2016 Wiley Periodicals, Inc.

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“…5 Rotavirus is a seasonal infection in developed western countries, with an annual peak in late winter. 6 The seasonal reduction in rotavirus cases following the introduction of childhood vaccination is marked, 7,8 and changes in seasonality with vaccination can lead to a peak every 2 years rather than annually. In developing equatorial countries rotavirus has been less seasonal than in developed western countries.…”

Section: Examining the Influence Of Weather On Rotavirus Infectionmentioning

confidence: 99%

Examining the influence of weather on rotavirus infection

Nichols

Iacono

2019

The Lancet Planetary Health

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Rapid Declines in Age Group–Specific Rotavirus Infection and Acute Gastroenteritis Among Vaccinated and Unvaccinated Individuals Within 1 Year of Rotavirus Vaccine Introduction in England and Wales

Abstract: The rapid declines in rotavirus infection and AGE in vaccinated and unvaccinated age groups within 1 year of introducing an infant rotavirus vaccination program are far greater than expected and than previously reported by other countries.

Cited by 78 publications

References 25 publications

Sustained reduction in rotavirus-coded hospitalizations in children aged <5 years after introduction of self-financed rotavirus vaccines in Japan

Sustained reduction in rotavirus-coded hospitalizations in children aged <5 years after introduction of self-financed rotavirus vaccines in Japan

Rotavirus epidemiology and surveillance before vaccine introduction in Argentina, 2012–2014

Examining the influence of weather on rotavirus infection

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