Rapid-course radiation therapy of cerebral metastases: Results and complications

Young, D. C.; Posner, Jerome B.; Chu, Florence C. H.; Nisce, Lourdes Z.

doi:10.1002/1097-0142(197410)34:4<1069::aid-cncr2820340416>3.0.co;2-4

Cited by 129 publications

(27 citation statements)

References 16 publications

(1 reference statement)

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“…Short radiation therapy courses have been tested by many authors (2,10,12,15), with results comparable to those obtained with conventional fractionation schedules (30-40 Gy in 2-4 weeks). However, no report has been published concerning multiple daily fractionation (MDF) in this clinical situation.…”

Section: Tionmentioning

confidence: 83%

Different Fractionation Schedules in Radiation Treatment of Cerebral Metastases

D’Elia

Bonucci

Biti

et al. 1986

Acta Radiologica: Oncology

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Section: Tionmentioning

confidence: 83%

Different Fractionation Schedules in Radiation Treatment of Cerebral Metastases

D’Elia

Bonucci

Biti

et al. 1986

Acta Radiologica: Oncology

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“…The Radiation Therapy Oncology Group (RTOG) 24 reported on single irradiation of 10 Gy/fraction (Fr) ϫ 1 Fr and 6 Gy/Fr ϫ 2 Fr; Young et al 25 reported on large single doses of 7.5 Gy/Fr ϫ 2 Fr over 2 weeks; Hindo et al 26 reported on doses of 10 Gy/ Fr; and Shehata et al 27 reported on doses of 10 Gy/Fr. Because patients with metastatic brain tumors are not expected to have a long survival time, the benefit of single high-dose WBRT is its short treatment period.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic radiosurgery (SRS) for multiple metastatic brain tumors: effects of the number of target tumors on exposure dose in normal brain tissues

Takahashi

Narabayashi

Kuroiwa

et al. 2003

International Journal of Clinical Oncology

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In SRS for multiple brain metastases, risks of both acute and late sequelae may increase because the exposure dose to normal brain tissues increases with increased numbers of target tumors. Dose distribution becomes more complex according to the increase in the number of targets. Based on our DVH curves, we conclude that the exposure dose to normal brain tissues is acceptable when the number of targets is less than 7. Importantly, our study also reveals that it may not be necessary or desirable to irradiate all metastatic tumors.

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“…The acute and the delayed effects may occur due to radiation induced cerebral oedema [6,7] and partly because of injury to the oligodendrocytes causing some disruptions in the synthesis of myelin. Unlike acute and delayed effects, the late effects are generally irreversible and progressive [8].…”

Section: Cranial Effects Of Whole Brain Radiotherapymentioning

confidence: 99%

Emerging Role of Neurocognitive Sparing Radiotherapy: Can it be the New Standard of Care?

Mitra¹,

Kataria²

2017

J Neurol Neurophysiol

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Whole-brain radiation therapy has been the standard form of treatment for advanced cancers, metastatic to the brain. It has the advantage of easy availability and delivery, and effectiveness in offering relief from symptoms for many suitable patients. Since most of these patients have poor outcomes and limited survival, oncologists in the past had a nihilistic approach and as a result, the potential toxicities emerging from WBRT have been largely neglected. With advances been made in neurosurgery, imaging, medical and radiation oncology, the results for many patients have improved significantly, particularly for those having favorable prognostic factors. Hence, the use of WBRT has come under scrutiny, due to its potential effect on the neurocognitive functions of the patient and their quality of life. This review article attempts to investigate if the various Neurocognitive sparing radiotherapy procedures can become a standard radiotherapy method for selected patients receiving whole brain radiotherapy for metastatic disease.

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Rapid-course radiation therapy of cerebral metastases: Results and complications

Cited by 129 publications

References 16 publications

Different Fractionation Schedules in Radiation Treatment of Cerebral Metastases

Different Fractionation Schedules in Radiation Treatment of Cerebral Metastases

Stereotactic radiosurgery (SRS) for multiple metastatic brain tumors: effects of the number of target tumors on exposure dose in normal brain tissues

Emerging Role of Neurocognitive Sparing Radiotherapy: Can it be the New Standard of Care?

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