Rapid Cortical Oscillations and Early Motor Activity in Premature Human Neonate

Milh, Mathieu; Kamińska, Anna; Huon, Catherine; Lapillonne, Alexandre; Ben-Ari, Yehezkel; Khazipov, Roustem

doi:10.1093/cercor/bhl069

Cited by 273 publications

(244 citation statements)

References 69 publications

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“…Occasionally, we also tried touching with bare examiner's finger which yielded comparable responses. We found it to be important that stimulus was given at a time when not much other EEG activity was present (13,14), and when no other limb movements were seen in the baby. It is obvious that both active (caused by the baby) and passive (caused by the clinician) body movements result in a sensory feedback from tendons and skin receptors (14 -16).…”

Section: Methodsmentioning

confidence: 98%

An Easy and Practical Method for Routine, Bedside Testing of Somatosensory Systems in Extremely Low Birth Weight Infants

Vanhatalo

Jousmäki²,

Andersson

et al. 2009

Pediatr Res

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This study was set out to develop and describe a novel, simple, and safe method for routine bedside testing of somatosensory system in very early preterm infants. We recorded electroencephalogram (EEG) activity after tactile stimulation of hand (palm) and foot (sole) by a soft hairbrush stimulator in extremely low birth weight infants (n ϭ 10; GA, 24 -28, recording at conceptional age 30 -32 wk) and compared with the raw EEG responses to those seen by one-or two-channel brain monitors. In every subject, single tactile stimuli produced prominent (100 -350 V) somatosensory evoked responses (SERs) that were readily identified in the ongoing EEG signal. The maximal SER was in the contralateral hemisphere at around the corresponding somatosensory representation areas. Conventional EEG filtering did significantly reduce the SERs, but they could still be identified in the routine brain monitor setting widely available in NICUs. The method described here is directly applicable to assessment of integrity of somatosensory system in the early preterm period. It needs minimal training and requires an EEG system or a brain monitor device that is available in most units. Thus, the technique is likely to open a novel window to neurologic assessment of these babies. (Pediatr Res 66: 710-713, 2009)

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Section: Methodsmentioning

confidence: 98%

An Easy and Practical Method for Routine, Bedside Testing of Somatosensory Systems in Extremely Low Birth Weight Infants

Vanhatalo

Jousmäki²,

Andersson

et al. 2009

Pediatr Res

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“…This interaction may induce functional differentiation of cortical layer IV (Wilkemeyer & Angelides 1996;Catalano & Shatz 1998;Anderson & Price 2002) and can be studied by optical recording and current source density analysis Higashi et al 2005). The most significant event related to the establishment of thalamocortical connectivity is the appearance of somatosensory evoked potentials (Molliver, 1967;Kostović & Jovanov-Miloše-vić, 2006;Vanhatalo & Kaila, 2006;Kostović & Judaš, 2007;Milh et al 2007). The thalamocortical pathways conducting impulses for pain sensation mature in the same period (Slater et al 2008;Lagercrantz & Changeux, 2009).…”

Section: Penetration Of the Cortical Plate (After 24-26 Pcw)mentioning

confidence: 99%

Development of axonal pathways in the human fetal fronto‐limbic brain: histochemical characterization and diffusion tensor imaging

et al. 2010

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The development of cortical axonal pathways in the human brain begins during the transition between the embryonic and fetal period, happens in a series of sequential events, and leads to the establishment of major long trajectories by the neonatal period. We have correlated histochemical markers (acetylcholinesterase (AChE) histochemistry, antibody against synaptic protein SNAP-25 (SNAP-25-immunoreactivity) and neurofilament 200) with the diffusion tensor imaging (DTI) database in order to make a reconstruction of the origin, growth pattern and termination of the pathways in the period between 8 and 34 postconceptual weeks (PCW). Histological sections revealed that the initial outgrowth and formation of joined trajectories of subcortico-frontal pathways (external capsule, cerebral stalk-internal capsule) and limbic bundles (fornix, stria terminalis, amygdaloid radiation) occur by 10 PCW. As early as 11 PCW, major afferent fibers invade the corticostriatal junction. At 13-14 PCW, axonal pathways from the thalamus and basal forebrain approach the deep moiety of the cortical plate, causing the first lamination. The period between 15 and 18 PCW is dominated by elaboration of the periventricular crossroads, sagittal strata and spread of fibers in the subplate and marginal zone. Tracing of fibers in the subplate with DTI is unsuccessful due to the isotropy of this zone. Penetration of the cortical plate occurs after 24-26 PCW. In conclusion, frontal axonal pathways form the periventricular crossroads, sagittal strata and 'waiting' compartments during the path-finding and penetration of the cortical plate. Histochemistry is advantageous in the demonstration of a growth pattern, whereas DTI is unique for demonstrating axonal trajectories. The complexity of fibers is the biological substrate of selective vulnerability of the fetal white matter.

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“…Spindle bursts are the rodent homolog of the "delta brush" pattern observed in the human EEG 25-38 weeks after gestation (André et al, 2010;Yang et al, 2016). In both rats and human preterm infants, spindle burst/delta brushes are triggered by sensory input in somatosensory (Khazipov et al, 2004;Milh et al, 2007), motor , and auditory (Chipaux et al, 2013) cortex and by hippocampal input to prefrontal cortex (Brockmann et al, 2011). Rodent studies show that the rapid oscillations are generated in thalamus in response to the input (Yang et al, 2013;Murata and Colonnese, 2016).…”

Section: Introductionmentioning

confidence: 99%

Development of Activity in the Mouse Visual Cortex

Shen¹,

Colonnese²

2016

J. Neurosci.

124

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A comprehensive developmental timeline of activity in the mouse cortex in vivo is lacking. Understanding the activity changes that accompany synapse and circuit formation is important to understand the mechanisms by which activity molds circuits and would help to identify critical checkpoints for normal development. To identify key principles of cortical activity maturation, we systematically tracked spontaneous and sensory-evoked activity with extracellular recordings of primary visual cortex (V1) in nonanesthetized mice. During the first postnatal week (postnatal days P4 -P7), V1 was not visually responsive and exhibited long (Ͼ10 s) periods of network silence. Activation consisted exclusively of "slow-activity transients," 2-10 s periods of 6 -10 Hz "spindle-burst' oscillations; the response to spontaneous retinal waves. By tracking daily changes in this activity, two key components of spontaneous activity maturation were revealed: (1) spindle-burst frequency acceleration (eventually becoming the 20 -50 Hz broadband activity caused by the asynchronous state) and (2) "filling-in" of silent periods with low-frequency (2-4 Hz) activity (beginning on P10 and complete by P13). These two changes are sufficient to create the adult-like pattern of continuous activity, alternation between fast-asynchronous and slowsynchronous activity, by eye opening. Visual responses emerged on P8 as evoked spindle-bursts and neuronal firing with a signal-tonoise ratio higher than adult. Both were eliminated by eye opening, leaving only the mature, short-latency response. These results identify the developmental origins of mature cortical activity and implicate the period before eye opening as a critical checkpoint. By providing a systematic description of electrical activity development, we establish the murine visual cortex as a model for the electroencephalographic development of fetal humans.

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Rapid Cortical Oscillations and Early Motor Activity in Premature Human Neonate

Cited by 273 publications

References 69 publications

An Easy and Practical Method for Routine, Bedside Testing of Somatosensory Systems in Extremely Low Birth Weight Infants

An Easy and Practical Method for Routine, Bedside Testing of Somatosensory Systems in Extremely Low Birth Weight Infants

Development of axonal pathways in the human fetal fronto‐limbic brain: histochemical characterization and diffusion tensor imaging

Development of Activity in the Mouse Visual Cortex

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