Rapid Control of a SARS-CoV-2 B.1.617.2 (Delta) Variant COVID-19 Community Outbreak: The Successful Experience in Pingtung County of Taiwan

Shy, Cherng-Gueih; Lu, Jian‐He; Lin, H. T.; Hung, Min-Nan; Chang, Hsiu-Chun; Lu, Meng-Lun; Chao, How‐Ran; Chen, Yao-Shen; Wang, Pi-Sheng

doi:10.3390/ijerph19031421

Cited by 11 publications

(13 citation statements)

References 24 publications

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“…The astonishing speed at which Delta spread led to outbreaks in many countries that had previously achieved elimination. For example, Delta outbreaks in Australia, Fiji, Vietnam, Singapore and Taiwan demonstrated how previous public health measures used to control COVID-19 were less effective against this highly transmissible variant [5][6][7][8][9] .…”

mentioning

confidence: 99%

Genomic epidemiology of Delta SARS-CoV-2 during transition from elimination to suppression in Aotearoa New Zealand

et al. 2022

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New Zealand’s COVID-19 elimination strategy heavily relied on the use of genomics to inform contact tracing, linking cases to the border and to clusters during community outbreaks. In August 2021, New Zealand entered its second nationwide lockdown after the detection of a single community case with no immediately apparent epidemiological link to the border. This incursion resulted in the largest outbreak seen in New Zealand caused by the Delta Variant of Concern. Here we generated 3806 high quality SARS-CoV-2 genomes from cases reported in New Zealand between 17 August and 1 December 2021, representing 43% of reported cases. We detected wide geographical spread coupled with undetected community transmission, characterised by the apparent extinction and reappearance of genomically linked clusters. We also identified the emergence, and near replacement, of genomes possessing a 10-nucleotide frameshift deletion that caused the likely truncation of accessory protein ORF7a. By early October, New Zealand moved from an elimination strategy to a suppression strategy and the role of genomics changed markedly from being used to track and trace, towards population-level surveillance.

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mentioning

confidence: 99%

Genomic epidemiology of Delta SARS-CoV-2 during transition from elimination to suppression in Aotearoa New Zealand

et al. 2022

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“…Both WHO 36 and CDC 37 identify 15 min of close exposure cumulatively over 24 h as a significant close contact duration. However, the 15‐min threshold is arbitrary and anecdotal evidence of fleeting contact resulting in transmission of SARS‐CoV‐2 virus has been reported in the media and elsewhere 38 . PFTs require the HCW to have direct patient contact for a minimum of 15 min and up to 120 min depending on tests ordered.…”

Section: Resultsmentioning

confidence: 99%

Pulmonary function testing during SARS‐CoV‐2: An ANZSRS/TSANZ position statement

Borg

Osadnik

Adam³

et al. 2022

Respirology

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The Thoracic Society of Australia and New Zealand (TSANZ) and the Australian and New Zealand Society of Respiratory Science (ANZSRS) commissioned a joint position paper on pulmonary function testing during coronavirus disease 2019 (COVID‐19) in July 2021. A working group was formed via an expression of interest to members of both organizations and commenced work in September 2021. A rapid review of the literature was undertaken, with a ‘best evidence synthesis’ approach taken to answer the research questions formed. This allowed the working group to accept findings of prior relevant reviews or societal document where appropriate. The advice provided is for providers of pulmonary function tests across all settings. The advice is intended to supplement local infection prevention and state, territory or national directives. The working group's key messages reflect a precautionary approach to protect the safety of both healthcare workers (HCWs) and patients in a rapidly changing environment. The decision on strategies employed may vary depending on local transmission and practice environment. The advice is likely to require review as evidence grows and the COVID‐19 pandemic evolves. While this position statement was contextualized specifically to the COVID‐19 pandemic, the working group strongly advocates that any changes to clinical/laboratory practice, made in the interest of optimizing the safety and well‐being of HCWs and patients involved in pulmonary function testing, are carefully considered in light of their potential for ongoing use to reduce transmission of other droplet and/or aerosol borne diseases.

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“…The wildtype ORF7a lineage peaked shortly after the first cases were discovered, with an Reff of 6.8 (and a 95% credible interval (CI) of 2. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Following this, Reff declined rapidly to around 1 for the remainder of the outbreak, likely as a result of a stringent public health response and high vaccination rates (86.4% of the eligible (>12 years of age) population by 1 December).…”

Section: Resultsmentioning

confidence: 99%

From elimination to suppression: genomic epidemiology of a large Delta SARS-CoV-2 outbreak in Aotearoa New Zealand

Jelley

Douglas

Ren

et al. 2022

Preprint

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New Zealand's COVID-19 elimination strategy heavily relied on the use of genomics to inform contact tracing, linking cases to the border and to clusters during community outbreaks. In August 2021, New Zealand entered its second nationwide lockdown after the detection of a single community case with no immediately apparent epidemiological link to the border. This incursion resulted in the largest outbreak seen in New Zealand caused by the Delta Variant of Concern. Here we generated 3806 high quality SARS-CoV-2 genomes from cases reported in New Zealand between 17 August and 1 December 2021, representing 43% of reported cases. We detected wide geographical spread coupled with undetected community transmission, characterised by the apparent extinction and reappearance of genomically linked clusters. We also identified the emergence, and near replacement, of genomes possessing a 10-nucleotide frameshift deletion that caused the likely truncation of accessory protein ORF7a. By early October, New Zealand moved from elimination to suppression and the role of genomics changed markedly from being used to track and trace, towards population-level surveillance.

show abstract

Rapid Control of a SARS-CoV-2 B.1.617.2 (Delta) Variant COVID-19 Community Outbreak: The Successful Experience in Pingtung County of Taiwan

Cited by 11 publications

References 24 publications

Genomic epidemiology of Delta SARS-CoV-2 during transition from elimination to suppression in Aotearoa New Zealand

Genomic epidemiology of Delta SARS-CoV-2 during transition from elimination to suppression in Aotearoa New Zealand

Pulmonary function testing during SARS‐CoV‐2: An ANZSRS/TSANZ position statement

From elimination to suppression: genomic epidemiology of a large Delta SARS-CoV-2 outbreak in Aotearoa New Zealand

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