Rapid comprehensive evaluation of luminography and hemodynamic function with 3d radially undersampled phase contrast imaging MRI

Johnson, Kevin M.; François, Christopher J.; Lum, Darren P.; Bley, Thorsten Alexander; Nett, Elisabeth; Landgraf, Benjamin R; Reeder, Scott B.; Grist, Thomas M.; Wieben, Oliver

doi:10.1109/iembs.2009.5333174

Cited by 4 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The remaining six healthy subjects used flip angle = 15°, and venc = 100 cm/s. An adaptive respiratory gating scheme using respiratory bellows and a 50% acceptance window resulted in scan times of ∼10–12 minutes depending on the respiratory rate of the subject (34). Retrospective electrocardiogram (ECG) gating with temporal filtering (35) similar to view sharing in Cartesian acquisitions was used.…”

Section: Methodsmentioning

confidence: 99%

In vivo validation of 4D flow MRI for assessing the hemodynamics of portal hypertension

Roldán‐Alzate

Frydrychowicz

Niespodzany

et al. 2012

Magnetic Resonance Imaging

103

View full text Add to dashboard Cite

Purpose to implement and validate in vivo radial 4D flow MRI for quantification of blood flow in the hepatic arterial, portal venous and splanchnic vasculature of healthy volunteers and patients with portal hypertension. Methods & Materials 17 patients with portal hypertension and 7 subjects with no liver disease were included in this HIPAA-compliant and IRB-approved study. Exams were conducted at 3T using a 32-channel body coil with large volumetric coverage and 1.4mm isotropic true spatial resolution. Using post-processing software, cut-planes orthogonal to vessels were used to quantify flow (L/min) in the hepatic and splanchnic vasculature. Results Flow quantification was successful in all cases. Portal vein and supra-celiac aorta flow demonstrated high variability among patients. Measurements were validated indirectly using internal consistency at three different locations within the portal vein (error=4.2±3.9%) and conservation of mass at the portal confluence (error=5.9±2.5%) and portal bifurcation (error=5.8±3.1%). Discussion This work demonstrates the feasibility of radial 4D flow MRI to quantify flow in the hepatic and splanchnic vasculature. Flow results agreed well with data reported in the literature, and conservation of mass provided indirect validation of flow quantification. Flow in patients with portal hypertensions demonstrated high variability with patterns and magnitude consistent with the hyperdynamic state that commonly occurs in portal hypertension.

show abstract

Section: Methodsmentioning

confidence: 99%

In vivo validation of 4D flow MRI for assessing the hemodynamics of portal hypertension

Roldán‐Alzate

Frydrychowicz

Niespodzany

et al. 2012

Magnetic Resonance Imaging

103

View full text Add to dashboard Cite

show abstract

“…Studies in patients were performed on 1.5 Tesla (T) (HDx) and 3.0T (HDx and MR750) scanners (GE Healthcare) while studies in normal volunteers were all performed at 3.0T (MR750, GE Healthcare). Following intravenous contrast administration (0.1 mmol/kg gadobenate dimeglumine, MultiHance, Bracco Diagnostics, Inc., Princeton, NJ), PC data were acquired using a four‐point PC VIPR sequence (24, 28, 29) with an eight‐channel body (1 patient) or cardiac (10 patients, 10 volunteers) coil. PC VIPR was performed after the administration of intravenous contrast to maximize the intravascular signal‐to‐noise ratio (30).…”

Section: Methodsmentioning

confidence: 99%

In vivo three‐dimensional MR wall shear stress estimation in ascending aortic dilatation

Bieging

Frydrychowicz

Wentland

et al. 2011

Magnetic Resonance Imaging

100

114

View full text Add to dashboard Cite

Purpose To estimate surface-based wall shear stress (WSS) and evaluate flow patterns in ascending aortic dilatation (AscAD) using a high-resolution, time-resolved, three-dimensional (3D), three-directional velocity encoded, radially undersampled phase contrast magnetic resonance sequence (4D PC-MRI). Materials and Methods 4D PC-MRI was performed in 11 patients with AscAD (46.3±22.0 years) and 10 healthy volunteers (32.9±13.4 years) after written informed consent and IRB-approval. Following manual vessel wall segmentation of the ascending aorta (MATLAB, The Mathworks, Natick, MA), a 3D surface was created using spline interpolation. Spatial WSS variation based on surface division in 12 segments and temporal variation were evaluated in AscAD and normal aortas. Visual analysis of flow patterns was performed based on streamlines and particle traces using EnSight (v9.0, CEI, Apex, NC). Results AscAD was associated with significantly increased diastolic WSS, decreased systolic to diastolic WSS ratio, and delayed onset of peak WSS (all P < 0.001). Temporally averaged WSS was increased and peak systolic WSS was decreased. The maximum WSS in AscAD was on the anterior wall of the ascending aorta. Vortical flow with highest velocities along the anterior wall and increased helical flow during diastole were observed in AscAD compared to controls. Conclusion Changes in WSS in the ascending aorta of AscAD correspond to observed alterations in flow patterns compared to controls.

show abstract

“…However, to achieve high-spatial-resolution and whole-brain coverage within a reasonable scan time, a 3D radial trajectory is used to speed the phase-contrast acquisition. 14,16,17 …”

Section: Methodsmentioning

confidence: 99%

Fast Contrast-Enhanced 4D MRA and 4D Flow MRI Using Constrained Reconstruction (HYPRFlow): Potential Applications for Brain Arteriovenous Malformations

Chang¹,

Wu²,

Johnson³

et al. 2015

AJNR Am J Neuroradiol

Self Cite

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: HYPRFlow is a novel imaging strategy that provides fast, high-resolution contrast-enhanced time-resolved images and measurement of the velocity of the entire cerebrovascular system. Our hypothesis was that the images obtained with this strategy are of adequate diagnostic image quality to delineate the major components of AVMs. MATERIALS AND METHODS: HYPRFlow and 3D TOF scans were obtained in 21 patients with AVMs with correlative DSA examinations in 14 patients. The examinations were scored for image quality and graded by using the Spetzler-Martin criteria. Mean arterial transit time and overlap integrals were calculated from the dynamic image data. Volume flow rates in normal arteries and AVM feeding arteries were measured from the phase contrast data. RESULTS: HYPRFlow was equivalent to 3D-TOF in delineating normal arterial anatomy, arterial feeders, and nidus size and was concordant with DSA for AVM grading and venous drainage in 13 of the 14 examinations. Mean arterial transit time on the AVM side was 0.49 seconds, and on the normal contralateral side, 2.53 seconds with P < .001. Across all 21 subjects, the mean arterial volume flow rate in the M1 segment ipsilateral to the AVM was 4.07 ± 3.04 mL/s; on the contralateral M1 segment, it was 2.09 ± 0.64 mL/s. The mean volume flow rate in the largest feeding artery to the AVM was 3.86 ± 2.74 mL/s. CONCLUSIONS: HYPRFlow provides an alternative approach to the MRA evaluation of AVMs, with the advantages of increased coverage, 0.75-second temporal resolution, 0.68-mm isotropic spatial resolution, and quantitative measurement of flow in 6 minutes.

show abstract

Rapid comprehensive evaluation of luminography and hemodynamic function with 3d radially undersampled phase contrast imaging MRI

Cited by 4 publications

References 9 publications

In vivo validation of 4D flow MRI for assessing the hemodynamics of portal hypertension

In vivo validation of 4D flow MRI for assessing the hemodynamics of portal hypertension

In vivo three‐dimensional MR wall shear stress estimation in ascending aortic dilatation

Fast Contrast-Enhanced 4D MRA and 4D Flow MRI Using Constrained Reconstruction (HYPRFlow): Potential Applications for Brain Arteriovenous Malformations

Contact Info

Product

Resources

About