Abstract:BACKGROUND: Activated protein C (APC) is one of the mechanisms contributing to coagulopathy, which is associated with high mortality. The counteraction of the APC pathway could help ameliorate bleeding. However, patients also transform frequently from a hemorrhagic state to a prothrombotic state at a later time. Therefore, a prohemostatic therapeutic intervention should take this thrombotic risk into consideration.
OBJECTIVES:CT-001 is a novel factor VIIa (FVIIa) with enhanced activity and desialylated N-glyca… Show more
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