2023
DOI: 10.3390/molecules28176349
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Rapid Chemical Profiling of Filipendula ulmaria Using CPC Fractionation, 2-D Mapping of 13C NMR Data, and High-Resolution LC–MS

Steve Thomas Pannakal,
Joan Eilstein,
Jane Hubert
et al.

Abstract: Filipendula ulmaria, commonly known as meadowsweet, is a wild herbaceous flowering plant that is widely distributed in Europe. A range of salicylic acid derivatives and flavonol glycosides have been previously associated with the antirheumatic and diuretic properties of F. ulmaria. In the present work, a hydroalcoholic extract from F. ulmaria aerial parts was extensively profiled using an efficient NMR-based dereplication strategy. The approach involves the fractionation of the crude extract by centrifugal par… Show more

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“…Despite the widespread use of meadowsweet extracts in folk medicine, the molecular components implicated in this or that activity in this species are poorly understood. Studies have linked important biological activities of F. ulmaria predominantly to secondary metabolites [72][73][74][75]. Salicylic acid, the metabolite of salicylic alcohol derivatives present in F. ulmaria, is responsible in part for the pharmacological activity of this plant [76].…”
Section: Discussionmentioning
confidence: 99%
“…Despite the widespread use of meadowsweet extracts in folk medicine, the molecular components implicated in this or that activity in this species are poorly understood. Studies have linked important biological activities of F. ulmaria predominantly to secondary metabolites [72][73][74][75]. Salicylic acid, the metabolite of salicylic alcohol derivatives present in F. ulmaria, is responsible in part for the pharmacological activity of this plant [76].…”
Section: Discussionmentioning
confidence: 99%