Rapid characterisation of the inherent dispersibility of respirable powders using dry dispersion laser diffraction

Jaffari, Sara; Forbes, Ben; Collins, Elizabeth; Barlow, David J.; Martin, Gary P.; Murnane, Darragh

doi:10.1016/j.ijpharm.2013.02.034

Cited by 52 publications

(42 citation statements)

References 37 publications

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“…The methodology used was similar to the one reported by Jaffari et al except that the primary range employed was in the range of 0.12-4.51 bar to investigate the indacaterol Breezhaler particle distribution density when the primary pressure changed (19).…”

Section: Particle Size Measurement Using Dry Dispersion Laser Diffracmentioning

confidence: 99%

Study of the Emitted Dose After Two Separate Inhalations at Different Inhalation Flow Rates and Volumes and an Assessment of Aerodynamic Characteristics of Indacaterol Onbrez Breezhaler® 150 and 300 μg

et al. 2017

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Abstract.Onbrez Breezhaler® is a low-resistance capsule-based device that was developed to deliver indacaterol maleate. The study was designed to investigate the effects of both maximum flow rate (MIF) and inhalation volume (Vin) on the dose emission of indacaterol 150 and 300 μg dose strengths after one and two inhalations using dose unit sampling apparatus (DUSA) as well as to study the aerodynamic characteristics of indacaterol Breezhaler® using the Andersen cascade impactor (ACI) at a different set of MIF and Vin. Indacaterol 150 and 300 μg contain equal amounts of lactose per carrier. However, 150 μg has the smallest carrier size. The particle size distribution (PSD) of indacaterol DPI formulations 150 and 300 μg showed that the density of fine particles increased with the increase of the primary pressure. For both strengths (150 μg and 300 μg), ED1 increased and ED2 decreased when the inhalation flow rate and inhaled volume increased. The reduction in ED1 and subsequent increase in ED2 was such that when the Vin is greater than 1 L, then 60 L/min could be regarded as the minimum MIF. The Breezhaler was effective in producing respirable particles with an MMAD ≤5 μm irrespective of the inhalation flow rate, but the mass fraction of particles with an aerodynamic diameter <3 μm is more pronounced between 60 and 90 L/min. The dose emission of indacaterol was comparable for both dose strengths 150 and 300 μg. These in vitro results suggest that a minimum MIF of 60 L/min is required during routine use of Onbrez Breezhaler®, and confirm the good practice to make two separate inhalations from the same dose.

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Section: Particle Size Measurement Using Dry Dispersion Laser Diffracmentioning

confidence: 99%

Study of the Emitted Dose After Two Separate Inhalations at Different Inhalation Flow Rates and Volumes and an Assessment of Aerodynamic Characteristics of Indacaterol Onbrez Breezhaler® 150 and 300 μg

et al. 2017

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“…Determination of the most suitable sampling technique is driven by a number of different considerations including the total mass, number concentration, size distribution and chemical composition of the particles to be characterized in addition to the size distribution technique to be used [17][18][19]. When sampling powders, there are two types of sampling errors possible that can affect the particle size analysis [20]; (i) errors due to segregation of the bulk powder which can be prevented by suitable mixing and (ii) statistical errors that are due to random fluctuations and cannot be prevented.…”

Section: Introductionmentioning

confidence: 99%

Particle size analysis on wide size distribution powders; effect of sampling and characterization technique

Basim

Khalili

2015

Advanced Powder Technology

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“…a). SS was a less cohesive powder, that is, required a smaller dispersing pressure compared with SX, which has recently been reported in formulation studies . The de‐agglomeration profile for SS was normalised (Fig.…”

Section: Resultsmentioning

confidence: 87%

Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation

Muddle

Murnane

Parisini

et al. 2015

Journal of Pharmaceutical Sciences

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Rapid characterisation of the inherent dispersibility of respirable powders using dry dispersion laser diffraction

Abstract: Graphical abstract

Cited by 52 publications

References 37 publications

Study of the Emitted Dose After Two Separate Inhalations at Different Inhalation Flow Rates and Volumes and an Assessment of Aerodynamic Characteristics of Indacaterol Onbrez Breezhaler® 150 and 300 μg

Study of the Emitted Dose After Two Separate Inhalations at Different Inhalation Flow Rates and Volumes and an Assessment of Aerodynamic Characteristics of Indacaterol Onbrez Breezhaler® 150 and 300 μg

Particle size analysis on wide size distribution powders; effect of sampling and characterization technique

Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation

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