Abstract:This study successfully demonstrated a significant cooling effect in rat brain by HRJVF. For preservation of brain function, HRJVF may be useful in resuscitation for trauma patients with hemorrhagic shock after further studies on animals with shock.
“…7 However, this approach may not be readily feasible in most clinical settings at present. Nasopharyngeal cooling or intraoperative cooling of the subdural space had a limited effect in lowering the brain temperature of adult patients.…”
Section: Wg Liu Ws Qiu Y Zhang Et Al Selective Brain Cooling Aftermentioning
confidence: 99%
“…2 -6 Since mild systemic hypothermia (MSH) leads to adverse sideeffects such as severe secondary infections and shock during re-warming, selective brain cooling (SBC) has been investigated for rapid local hypothermia. 5,7 Despite its promise, the clinical benefits of SBC have rarely been investigated. 5 In order to evaluate the effects of SBC in patients with severe TBI, we conducted a randomized, controlled clinical trial of SBC, MSH and normothermia in patients with severe TBI, and the clinical effects were analysed prospectively.…”
Section: Introductionmentioning
confidence: 99%
“…Rapid induction of cooling by intravenous administration of cold crystalloid is another technique. 3,7,14 Recently, Ding et al 14 described the production of SBC by regional cooling with local infusion of saline into ischaemic brain territory; in their in vivo study, prereperfusion infusion effectively induced hypothermia and ameliorated brain injury. It has been demonstrated that early head cooling is effective in preventing some of the earliest brain damage, even in the absence of profound systemic hypothermia.…”
We prospectively investigated noninvasive selective brain cooling (SBC) in patients with severe traumatic brain injury.Sixty-six in-patients were randomized into three groups. In one group, brain temperature was maintained at 33 -35°C by cooling the head and neck (SBC); in a second group, mild systemic hypothermia (MSH; rectal temperature 33 -35°C) was produced with a cooling blanket; and a control group was not exposed to hypothermia. Natural rewarming began after 3 days. Mean intracranial pressure 24, 48 or 72 h after injury was significantly lower in the SBC group than in the control group. Mean serum superoxide dismutase levels on Days 3 and 7 after injury in the SBC and MSH groups were significantly higher than in the control group. The percentage of patients with a good neurological outcome 2 years after injury was 72.7%, 57.1% and 34.8% in the SBC, MSH and control groups, respectively. Complications were managed without severe sequelae. Non-invasive SBC was safe and effective.
“…7 However, this approach may not be readily feasible in most clinical settings at present. Nasopharyngeal cooling or intraoperative cooling of the subdural space had a limited effect in lowering the brain temperature of adult patients.…”
Section: Wg Liu Ws Qiu Y Zhang Et Al Selective Brain Cooling Aftermentioning
confidence: 99%
“…2 -6 Since mild systemic hypothermia (MSH) leads to adverse sideeffects such as severe secondary infections and shock during re-warming, selective brain cooling (SBC) has been investigated for rapid local hypothermia. 5,7 Despite its promise, the clinical benefits of SBC have rarely been investigated. 5 In order to evaluate the effects of SBC in patients with severe TBI, we conducted a randomized, controlled clinical trial of SBC, MSH and normothermia in patients with severe TBI, and the clinical effects were analysed prospectively.…”
Section: Introductionmentioning
confidence: 99%
“…Rapid induction of cooling by intravenous administration of cold crystalloid is another technique. 3,7,14 Recently, Ding et al 14 described the production of SBC by regional cooling with local infusion of saline into ischaemic brain territory; in their in vivo study, prereperfusion infusion effectively induced hypothermia and ameliorated brain injury. It has been demonstrated that early head cooling is effective in preventing some of the earliest brain damage, even in the absence of profound systemic hypothermia.…”
We prospectively investigated noninvasive selective brain cooling (SBC) in patients with severe traumatic brain injury.Sixty-six in-patients were randomized into three groups. In one group, brain temperature was maintained at 33 -35°C by cooling the head and neck (SBC); in a second group, mild systemic hypothermia (MSH; rectal temperature 33 -35°C) was produced with a cooling blanket; and a control group was not exposed to hypothermia. Natural rewarming began after 3 days. Mean intracranial pressure 24, 48 or 72 h after injury was significantly lower in the SBC group than in the control group. Mean serum superoxide dismutase levels on Days 3 and 7 after injury in the SBC and MSH groups were significantly higher than in the control group. The percentage of patients with a good neurological outcome 2 years after injury was 72.7%, 57.1% and 34.8% in the SBC, MSH and control groups, respectively. Complications were managed without severe sequelae. Non-invasive SBC was safe and effective.
“…In 2005, Wen et al 43 performed a feasibility experiment assessing hypothermic retrograde jugular flush as an alternative to carotid artery infusion. The external jug ular veins of rats were cannulated and infused with cold saline at 2 temperatures, 4° or 24°C, over a period of 10 minutes.…”
Section: Endovascular Coolingmentioning
confidence: 99%
“…Hypothermic retrograde jugular flush appears to be an effective means of achieving rapid preferential hypothermia, although it is associated with increases in cerebral blood flow. 43 Conflicts regarding ICP dynamics and rates of thrombocytopenia or coagulopathy in conjunction with endovascular methods of selective hypothermia remain to be studied but may pose significant limitations in patients with TBI.…”
ObjectTraumatic brain injury (TBI) remains a significant cause of morbidity and death in the US and worldwide. Resuscitative systemic hypothermia following TBI has been established as an effective neuroprotective treatment in multiple studies in animals and humans, although this intervention carries with it a significant risk profile as well. Selective, or preferential, methods of inducing cerebral hypothermia have taken precedence over the past few years in order to minimize systemic adverse effects. In this report, the authors explore the current methods available for inducing selective cerebral hypothermia following TBI and review the literature regarding the results of animal and human trials in which these methods have been implemented.MethodsA search of the PubMed archive (National Library of Medicine) and the reference lists of all relevant articles was conducted to identify all animal and human studies pertaining to the use of selective brain cooling, selective hypothermia, preferential hypothermia, or regional hypothermia following TBI.ResultsMultiple methods of inducing selective cerebral hypothermia are currently in the experimental phases, including surface cooling, intranasal selective hypothermia, transarterial or transvenous endovascular cooling, extraluminal vascular cooling, and epidural cerebral cooling.ConclusionsSeveral methods of conferring preferential neuroprotection via selective hypothermia currently are being tested. Class I prospective clinical trials are required to assess the safety and efficacy of these methods.
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at
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