“…After 2 years of synthesis, the variations in size of Au NPs due to the presence of functional groups on the GF-Au NPs have not been significant, which confirms the stability of the green synthesized GF-Au NPs. The existence of polyphenols in the plant that acts as a covering agent prevents the aggregation of particles, which is a great advantage of the green synthesis method compared to the chemical synthesized way (Kanawaria et al 2018 ; Dehghani et al 2022 ). Fig.…”
Nowadays, nanoparticles such as gold nanoparticles (Au NPs) with specific biophysical characteristics have attracted remarkable attention as innovative options for the diagnosis and treatment of different diseases. In the present research, Au NPs were green synthesized using the
Glaucium flavum
leaf extract as an inexpensive and eco-friendly synthesis method. Then, the physicochemical properties were characterized by transmission electron microscopy (TEM), dynamic light scattering method (DLS), scanning electron microscopy (SEM), X-ray diffraction (XRD), Ultraviolet–visible absorption spectroscopy (UV–Vis), Zeta potential, and Fourier transform infrared (FTIR) spectroscopy. Afterwards, the antioxidant capacity was tested and antiviral activity against influenza virus was evaluated by applying TCID50 and PCR assays. The nanoparticles cytotoxicity was tested using the MTT method. The shape and size of Au nanoparticles were modulated by varying leaf concentrations with face-centered cubic (FCC) structure. At higher concentrations, long-time stable spherical nanoparticles were obtained with a mean particle size of 32 nm and low aggregation degree that could simply combine with various bioactive compounds. The outcomes exhibited effective antiviral and antioxidant activities with low cytotoxicity and acceptable biocompatibility of green synthesized Au NPs. The aim of the present study was to develop a potentially environmentally friendly nanoplatform with excellent antiviral and antioxidant functions and acceptable biocompatibility for promising biomedical applications in the future.
Supplementary Information
The online version contains supplementary material available at 10.1007/s13204-022-02705-1.
“…After 2 years of synthesis, the variations in size of Au NPs due to the presence of functional groups on the GF-Au NPs have not been significant, which confirms the stability of the green synthesized GF-Au NPs. The existence of polyphenols in the plant that acts as a covering agent prevents the aggregation of particles, which is a great advantage of the green synthesis method compared to the chemical synthesized way (Kanawaria et al 2018 ; Dehghani et al 2022 ). Fig.…”
Nowadays, nanoparticles such as gold nanoparticles (Au NPs) with specific biophysical characteristics have attracted remarkable attention as innovative options for the diagnosis and treatment of different diseases. In the present research, Au NPs were green synthesized using the
Glaucium flavum
leaf extract as an inexpensive and eco-friendly synthesis method. Then, the physicochemical properties were characterized by transmission electron microscopy (TEM), dynamic light scattering method (DLS), scanning electron microscopy (SEM), X-ray diffraction (XRD), Ultraviolet–visible absorption spectroscopy (UV–Vis), Zeta potential, and Fourier transform infrared (FTIR) spectroscopy. Afterwards, the antioxidant capacity was tested and antiviral activity against influenza virus was evaluated by applying TCID50 and PCR assays. The nanoparticles cytotoxicity was tested using the MTT method. The shape and size of Au nanoparticles were modulated by varying leaf concentrations with face-centered cubic (FCC) structure. At higher concentrations, long-time stable spherical nanoparticles were obtained with a mean particle size of 32 nm and low aggregation degree that could simply combine with various bioactive compounds. The outcomes exhibited effective antiviral and antioxidant activities with low cytotoxicity and acceptable biocompatibility of green synthesized Au NPs. The aim of the present study was to develop a potentially environmentally friendly nanoplatform with excellent antiviral and antioxidant functions and acceptable biocompatibility for promising biomedical applications in the future.
Supplementary Information
The online version contains supplementary material available at 10.1007/s13204-022-02705-1.
“…In opposite to bacteria and yeasts, the research on the interactions of AgNPs with filamentous fungi (molds) is still evolving (Kanawaria et al 2018). The results on AgNPs' effects on fungal growth already reported concern mainly dermatophytes and phyto pathogens (Jo et al 2009;Pulit et al 2013;Xu et al 2013), not the molds found in houses or the air.…”
Section: Introductionmentioning
confidence: 99%
“…However, some cytostatic and anti-cancer activity is reported at these concentrations (AshaRani et al 2009). Antibacterial activity of AgNPs 4 516 is rather well documented in the literature, mainly against the following species: Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli (Yoon et al 2007;Li et al 2010;Guzman et al 2012, Kanawaria et al 2018). Some information concerning growth inhibition of other bacteria (Enterococcus spp.)…”
The progress of research on silver nanoparticles (AgNPs) has led to their inclusion in many consumer products (chemicals, cosmetics, clothing, water filters, and medical devices) as a biocide. Despite the widespread use of AgNPs, their biocidal activity is not yet fully understood and is usually associated with various factors (size, composition, surface, red-ox potential, and concentration) and, obviously, specific features of microorganisms. There are merely a few studies concerning the interaction of molds with AgNPs. Therefore, the determination of the minimal AgNPs concentration required for effective growth suppression of five fungal species (Paecilomyces variotii, Penicillium pinophilum, Chaetomium globosum, Trichoderma virens, and Aspergillus brasiliensis), involved in the deterioration of construction materials, was particularly important. Inhibition of bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli) and yeasts (Candida albicans and Yarrowia lipolytica) was also assessed as the control of AgNPs effectiveness. AgNPs at the concentrations of 9–10.7 ppm displayed high inhibitory activity against moulds, yeast, and bacteria. The TEM images revealed that 20 nm AgNPs migrated into bacterial, yeast, and fungal cells but aggregated in larger particles (50–100 nm) exclusively inside eukaryotic cells. The aggregation of 20 nm AgNPs and particularly their accumulation in the cell wall, observed for A. brasiliensis cells, are described here for the first time.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
