Rapid Automated Algorithm for Aligning and Reslicing PET Images

Woods, Roger P.; Cherry, Simon R.; Mazziotta, John C.

doi:10.1097/00004728-199207000-00024

Cited by 1,745 publications

(899 citation statements)

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“…These differences were evaluated using Statistical Parametric Mapping (SPM 99), (SPM Web page, 2002, www.fil.ion.ucl.ac.uk/spm/software/spm99). Automated image coregistration (Woods et al, 1992) was used to align the 12 frames within each study (Mann et al, 1996b). The resulting summarized image was transformed into standard stereotaxic atlas space (Talairach and Tournoux, 1988).…”

Section: Image Analysismentioning

confidence: 99%

Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge in Major Depressive Disorder with and without Borderline Personality Disorder

Oquendo

Krunic

Parsey

et al. 2005

Neuropsychopharmacol

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Previous neuroimaging studies of major depression have not controlled for the presence of personality disorders characterized by impulsive aggressive behavior, such as borderline personality disorder (BPD). Using positron emission tomography (PET), we studied regional glucose uptake in response to fenfluramine (FEN) in depressed subjects with BPD (n ¼ 11) and depressed patients without Cluster B Axis II disorders (n ¼ 8). Subjects were scanned while medication-free after a single blind placebo administration and after FEN on a second day. Brain responses were measured by PET imaging of [ 18 F]fluorodeoxyglucose (FDG) and serial prolactin levels. Scans were compared at a voxel level using statistical parametric mapping. Correlations of changes in relative regional cerebral uptake (rCMRglu) with clinical measures were assessed. Depressed borderline patients had greater relative activity in parietotemporal cortical regions (BA 40, BA 22, and BA 42) before and after FEN activation compared to those without BPD. They also had less relative uptake in the anterior cingulate cortex (BA 32) at baseline compared to depressed patients without BPD and FEN abolished this difference. Impulsivity was positively correlated with rCMRglu in superior and middle frontal cortex (BA 6 and 44). Hostility was positively correlated with rCMRglu in temporal cortical regions (BA 21 and 22). In conclusions, borderline pathology in the context of a Major Depressive Disorder is associated with altered activity in parietotemporal and anterior cingulate cortical regions. Controlling for the presence of BPD in future imaging studies of mood disorders may elucidate similarities and differences in regional serotonergic function in these two often comorbid disorders.

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Section: Image Analysismentioning

confidence: 99%

Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge in Major Depressive Disorder with and without Borderline Personality Disorder

Oquendo

Krunic

Parsey

et al. 2005

Neuropsychopharmacol

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“…Each subject's images were realigned in 3D space using Wood's automated image registration (AIR) algorithm [Woods et al, 1992]. All subjects' data were then registered to one representative subject's brain and pooled.…”

Section: Image Analysismentioning

confidence: 99%

Sensitivity of prefrontal cortex to changes in target probability: A functional MRI study

Casey

Forman

Franzen

et al. 2001

Human Brain Mapping

148

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Electrophysiological studies suggest sensitivity of the prefrontal cortex to changes in the probability of an event. The purpose of this study was to determine if subregions of the prefrontal cortex respond differentially to changes in target probabilities using functional magnetic resonance imaging (fMRI). Ten right-handed adults were scanned using a gradient-echo, echo planar imaging sequence during performance of an oddball paradigm. Subjects were instructed to respond to any letter but "X". The frequency of targets (i.e., any letter but X) varied across trials. The results showed that dorsal prefrontal regions were active during infrequent events and ventral prefrontal regions were active during frequent events. Further, we observed an inverse relation between the dorsal and ventral prefrontal regions such that when activity in dorsal prefrontal regions increased, activity in ventral prefrontal regions decreased, and vice versa. This finding may index competing cognitive processes or capacity limitations. Most importantly, these findings taken as a whole suggest that any simple theory of prefrontal cortex function must take into account the sensitivity of this region to changes in target probability. Hum. Brain Mapping 13:26 -33, 2001.

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“…The images from each experiment were first registered with a motion correction algorithm (AIR 3.0) (Woods et al 1992), and the signal time series in each voxel was linearly detrended with the AFNI software package (Cox 1996). For each subject in each condition (TD and FT, amphetamine and placebo), an individual correlation map was generated by cross correlating the time course of the fMRI signal in each pixel with a Figure 1.…”

Section: Image Analysismentioning

confidence: 99%