Rapid assessment of pulmonary gas transport with hyperpolarized 129<scp>X</scp>e <scp>MRI</scp> using a 3<scp>D</scp> radial double golden‐means acquisition with variable flip angles

Ruppert, K.; Amzajerdian, F.; Hamedani, Hooman; Xin, Yi; Loza, L.; Achekzai, T.S.; Duncan, I.; Profka, Harrilla; Siddiqui, S.; Pourfathi, M.; Cereda, Maurizio; Kadlecek, Stephen; Rizi, Rahim R.

doi:10.1002/mrm.27217

Cited by 8 publications

(8 citation statements)

References 49 publications

(61 reference statements)

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“…Second, pulmonary physiological status was evaluated on the seventh day after the instillation; more time points should be added to investigate the evolution of injury caused by PM 2.5 . Third, as a concept‐of‐proof study, only whole‐lung gas exchange was measured using CSSR; however, dissolved xenon imaging techniques should also be added for visualizing the heterogeneity of gas exchange caused by PM 2.5 ‐related diseases in future studies . Also, the diffusing capacity of the lungs for carbon monoxide should be added in future studies to comprehensively evaluate changes in gas exchange function caused by PM 2.5 .…”

Section: Discussionmentioning

confidence: 99%

“…Hyperpolarized 129 Xe MR has been proven to be a powerful tool to evaluate the pulmonary function and microstructure attributed to its extremely high MR sensitivity . As a noninvasive, ionizing radiation‐free technique, hyperpolarized 129 Xe MR enables quantifying the changes in pulmonary ventilation, microstructure, and gas exchange function, which have been widely used to study various lung diseases.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Zhang

et al. 2019

Magnetic Resonance in Med

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Purpose:To demonstrate the feasibility of 129 Xe MR in evaluating the pulmonary physiological changes caused by PM 2.5 in animal models. Methods: Six rats were treated with PM 2.5 solution (16.2 mg/kg) by intratracheal instillation twice a week for 4 weeks, and another six rats treated with normal saline served as the control cohort. Pulmonary function tests, hyperpolarized 129 Xe multi-b diffusion-weighted imaging, and chemical shift saturation recovery MR spectroscopy were performed on all rats, and the pulmonary structure and functional parameters were obtained from hyperpolarized 129 Xe MR data. Additionally, histological analysis was performed on all rats to evaluate alveolar septal thickness. Statistical analysis of all the obtained parameters was performed using unpaired 2-tailed t tests. Results: Compared with the control group, the measured exchange time constant increased from 11.74 ± 2.39 to 14.00 ± 2.84 ms (P < .05), and the septal wall thickness increased from 6.17 ± 0.48 to 6.74 ± 0.52 μm (P < .05) in the PM 2.5 cohort by 129 Xe MR spectroscopy, which correlated well with that obtained using quantitative histology (increased from 5.52 ± 0.32 to 6.20 ± 0.36 μm). Additionally, the mean TP/GAS ratio increased from 0.828 ± 0.115 to 1.019 ± 0.140 in the PM 2.5 cohort (P = .021). Conclusions: Hyperpolarized 129 Xe MR could quantify the changes in gas exchange physiology caused by PM 2.5 , indicating that the technique has the potential to be a useful tool for evaluation of pulmonary injury caused by air pollution in the future. K E Y W O R D Sair pollution, gas exchange, hyperpolarized 129 Xe, lung injury, PM 2.5 570 | ZHANG et Al.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Zhang

et al. 2019

Magnetic Resonance in Med

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“…Several limitations still existed in this study. First, the proposed method could only obtain the global pulmonary blood‐gas exchange parameters, and dissolved xenon imaging technologies should be combined with lung morphometric measurement and the advanced DWI method to comprehensively understand the microstructure and functions of the human lung using HP 129 Xe MR in the future. Second, the number of subjects was limited, and more healthy older subjects should be recruited to evaluate the changes in lung function and microstructure caused by age.…”

Section: Discussionmentioning

confidence: 99%

Single breath‐hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized ¹²⁹Xe MR

Xie

Zhang

et al. 2019

NMR in Biomedicine

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Pulmonary diseases usually result in changes of the blood-gas exchange function in the early stages. Gas exchange across the respiratory membrane and gas diffusion in the alveoli can be quantified using hyperpolarized 129 Xe MR via chemical shift saturation recovery (CSSR) and diffusion-weighted imaging (DWI), respectively.Generally, CSSR and DWI data have been collected in separate breaths in humans.Unfortunately, the lung inflation level cannot be the exactly same in different breaths, which causes fluctuations in blood-gas exchange and pulmonary microstructure. Here we combine CSSR and DWI obtained with compressed sensing, to evaluate the gas diffusion and exchange function within a single breath-hold in humans. A new parameter, namely the perfusion factor of the respiratory membrane (SVR d/g ), is proposed to evaluate the gas exchange function. Hyperpolarized 129 Xe MR data are compared with pulmonary function tests and computed tomography examinations in healthy young, age-matched control, and chronic obstructive pulmonary disease human cohorts. SVR d/g decreases as the ventilation impairment and emphysema index increase. Our results indicate that the proposed method has the potential to detect the extent of lung parenchyma destruction caused by age and pulmonary diseases, and it would be useful in the early diagnosis of pulmonary diseases in clinical practice.

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“…Moreover, most HP gas MRI methods acquire data during a single breath‐hold, but long breath‐holding time imposes burdens on subjects, especially for those patients with compromised respiratory function. Accordingly, various efforts have focused on accelerating the acquisition of HP gas MRI, including methods based on parallel imaging, radial, spiral, compressed sensing MRI (CS‐MRI), or the combination of these techniques . Among them, CS‐MRI is a good solution to shorten scan time by undersampling measurements in k‐space, and without additional hardware required …”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, various efforts have focused on accelerating the acquisition of HP gas MRI, including methods based on parallel imaging, 4 radial, 5 spiral, 6 compressed sensing MRI (CS-MRI), 7 or the combination of these techniques. 8,9 Among them, CS-MRI is a good solution to shorten scan time by undersampling measurements in k-space, and without additional hardware required. 10 Ajraoui et al first applied CS to reconstruct HP 3 He lung images at an acceleration factor (AF) of 2 for 2D images and 5 for 3D ventilation images.…”

Section: Introductionmentioning

confidence: 99%

Fast and accurate reconstruction of human lung gas MRI with deep learning

Duan

Xiao

et al. 2019

Magnetic Resonance in Med

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Purpose To fast and accurately reconstruct human lung gas MRI from highly undersampled k‐space using deep learning. Methods The scheme was comprised of coarse‐to‐fine nets (C‐net and F‐net). Zero‐filling images from retrospectively undersampled k‐space at an acceleration factor of 4 were used as input for C‐net, and then output intermediate results which were fed into F‐net. During training, a L2 loss function was adopted in C‐net, while a function that united L2 loss with proton prior knowledge was used in F‐net. The 871 hyperpolarized 129Xe pulmonary ventilation images from 72 volunteers were randomly arranged as training (90%) and testing (10%) data. Ventilation defect percentage comparisons were implemented using a paired 2‐tailed Student's t‐test and correlation analysis. Furthermore, prospective acquisitions were demonstrated in 5 healthy subjects and 5 asymptomatic smokers. Results Each image with size of 96 × 84 could be reconstructed within 31 ms (mean absolute error was 4.35% and structural similarity was 0.7558). Compared with conventional compressed sensing MRI, the mean absolute error decreased by 17.92%, but the structural similarity increased by 6.33%. For ventilation defect percentage, there were no significant differences between the fully sampled and reconstructed images through the proposed algorithm (P = 0.932), but had significant correlations (r = 0.975; P < 0.001). The prospectively undersampled results validated a good agreement with fully sampled images, with no significant differences in ventilation defect percentage but significantly higher signal‐to‐noise ratio values. Conclusion The proposed algorithm outperformed classical undersampling methods, paving the way for future use of deep learning in real‐time and accurate reconstruction of gas MRI.

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Rapid assessment of pulmonary gas transport with hyperpolarized 129Xe MRI using a 3D radial double golden‐means acquisition with variable flip angles

Abstract: 3D radial double golden-means acquisitions with variable flip angles provide a robust means for rapidly assessing lung function during a single breath hold, thereby constituting a particularly valuable tool for imaging uncooperative or pediatric patient populations.

Cited by 8 publications

References 49 publications

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Single breath‐hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized ¹²⁹Xe MR

Fast and accurate reconstruction of human lung gas MRI with deep learning

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Rapid assessment of pulmonary gas transport with hyperpolarized 129Xe MRI using a 3D radial double golden‐means acquisition with variable flip angles

Abstract: 3D radial double golden-means acquisitions with variable flip angles provide a robust means for rapidly assessing lung function during a single breath hold, thereby constituting a particularly valuable tool for imaging uncooperative or pediatric patient populations.

Cited by 8 publications

References 49 publications

Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance

Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance

Single breath‐hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized 129Xe MR

Fast and accurate reconstruction of human lung gas MRI with deep learning

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Product

Resources

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Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Single breath‐hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized ¹²⁹Xe MR