Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways

Hou, Xiaoyi; Hu, Zhuang-Li; Zhang, Deng-Zheng; Lü, Wei; Zhou, Jun; Wu, Pengfei; Guan, Xin-Lei; Han, Qian-Qian; Deng, Si-Long; Zhang, Hai; Chen, Jianguo; Wang, Fang

doi:10.1089/ars.2016.6737

Cited by 40 publications

(26 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, H 2 S ameliorated hepatic ischemia/reperfusion injury by stimulating phosphorylation of the pyruvate dehydrogenase kinase 1 (PDK-1)/Akt (protein kinase B)/mTOR/70 kDa ribosomal protein S6 kinase (p70S6K) axis [ 76 ]. The effects of H 2 S on mTOR activation are consistent with the mechanism of rapid-onset antidepressants [ 70 ].…”

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 60%

“…To understand the actions and underlying mechanisms of H 2 S related to depressive-like behavior, a recent study (intraperitoneally) injected the H 2 S donor NaHS or administered inhaled H 2 S in a chronic unpredictable mild stress (CUMS) model. The role of the mechanistic target of rapamycin (mTOR) signaling pathway and glutamate receptors ( Figure 2 ) in the antidepressant effects of H 2 S was evaluated [ 70 ]. The results indicated that a deficiency in endogenous H 2 S in the hippocampus is responsible for the abnormal behaviors associated with CUMS, whereas enhancing hippocampal H 2 S levels by the administration of NaHS or inhalation of H 2 S could correct the depressive-like behaviors of rats within a few hours.…”

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 99%

“…This suggests that H 2 S could function as a rapid-onset antidepressant. Additionally, H 2 S could counteract the loss of dendritic spines in the hippocampus that is associated with CUMS [ 70 ].…”

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 99%

“…This suggests that the synaptogenesis induced by glutamate receptor activation requires the release of BDNF to activate TrKB-mTOR signaling and synaptic protein synthesis ( Figure 2 ). In another study, it was unclear whether the peripheral effects of H 2 S played a role in the antidepressant responses; thus, additional studies are needed [ 70 ]. Nevertheless, this study also demonstrated that the acute application of H 2 S, via either the H 2 S donor NaHS or H 2 S gas inhalation, induced robust antidepressant effects that were mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway followed by the enhanced synthesis of synaptic proteins containing postsynaptic density protein 95 (PSD95) and synaptophysin.…”

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 99%

“…H 2 S also increases the levels of TrKB receptors, which further increases the activity of the GluR1 and GluR2 subunits of AMPARs. An improved understanding of the roles of H 2 S could provide insight into potential therapeutic interventions for depression [ 70 ].…”

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 99%

See 4 more Smart Citations

Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions

Shefa

Kim

et al. 2018

Neural Plasticity

View full text Add to dashboard Cite

Synaptic plasticity is important for maintaining normal neuronal activity and proper neuronal functioning in the nervous system. It is crucial for regulating synaptic transmission or electrical signal transduction to neuronal networks, for sharing essential information among neurons, and for maintaining homeostasis in the body. Moreover, changes in synaptic or neural plasticity are associated with many neuropsychiatric conditions, such as schizophrenia (SCZ), bipolar disorder (BP), major depressive disorder (MDD), and Alzheimer's disease (AD). The improper maintenance of neural plasticity causes incorrect neurotransmitter transmission, which can also cause neuropsychiatric conditions. Gas neurotransmitters (gasotransmitters), such as hydrogen sulfide (H2S), nitric oxide (NO), and carbon monoxide (CO), play roles in maintaining synaptic plasticity and in helping to restore such plasticity in the neuronal architecture in the central nervous system (CNS). Indeed, the upregulation or downregulation of these gasotransmitters may cause neuropsychiatric conditions, and their amelioration may restore synaptic plasticity and proper neuronal functioning and thereby improve such conditions. Understanding the specific molecular mechanisms underpinning these effects can help identify ways to treat these neuropsychiatric conditions.

show abstract

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 60%

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 99%

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 99%

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 99%

Section: Role Of Gasotransmitters In Neuropsychiatric Diseasementioning

confidence: 99%

See 3 more Smart Citations

Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions

Shefa

Kim

et al. 2018

Neural Plasticity

View full text Add to dashboard Cite

show abstract

Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress

Zeng

Tian

et al. 2020

Anim Models and Exp Med

View full text Add to dashboard Cite

Background:The chronic unpredictable mild stress (CUMS) model has long been considered the best model for exploring the pathophysiological mechanisms underlying depression. However, there are no widely recognised standards for strategies for modeling and for behavioral testing. The present study aimed to optimize the protocols for food deprivation and the sucrose preference test (SPT) for the CUMS model. Methods:We first evaluated the effects of different long periods of food deprivation on the body weight of Sprague Dawley (SD) rats by testing food deprivation for 24 hours (8:00-8:00 + ), food deprivation for 12 hours during the daytime (8:00-20:00) and food deprivation for 12 hours at night (20:00-8:00 + ). Next, we established a SD rat CUMS model with 15 different stimulations, and used body weight measurement, SPT, forced swim test (FST), open field test (OFT) and Morris water maze (MWM) test to verify the success of the modeling. In the SPT, consumption of sucrose and pure water within 1 and 12 hours was measured.Results: Twelve hours of food deprivation during the daytime (8:00-20:00) had no effect on body weight, while 12 hours of food deprivation at night (20:00-8:00 + ) and 24 hours of food deprivation (8:00-8:00 + ) significantly reduced the mean body weight of the SD rats. When SPT was used to verify the successful establishment of the CUMS rat model, sucrose consumption measured within 12 hours was less variable than that measured within 1 hour. Conclusions:Twelve hours of food deprivation in the daytime (8:00-20:00) may be considered a mild stimulus for the establishment of a CUMS rat model. Measuring sucrose consumption over 12 hours is recommended for SPT. K E Y W O R D S chronic unpredictable mild stress, forced swim test, Morris water maze, open field test, sucrose preference test, weight body

show abstract

One‐Step Synthesis of Chitosan Hydrogel as Electrochemical Chemosensor for Hydrogen Sulfide Detection in Pregnancy‐Induced Hypertension Syndrome Serum Sample

Fang,

Li,

Lin

et al. 2024

ChemistryOpen

View full text Add to dashboard Cite

Oxidative stress caused by pregnancy‐induced hypertension syndrome significantly affects the health of pregnant women. Hydrogen sulfide is a typical gaseous signal molecule against oxidative stress, and it is of profound significance to develop a detection method. In this study, a stimuli‐responsive hydrogel was constructed based on the coordination and bonding principle of metal ions and chitosan (CS) to realize the quantitative detection of hydrogen sulfide (H2S). The chain of CS contains a large number of amino groups and hydroxyl groups, which can form the coordination structure with Cu2+, triggering CS to form a stable hydrogel. The hydrogel can be formed within about 5 s, which has the characteristics of rapid preparation. In the presence of target H2S, the cross‐linking agent Cu2+ in the hydrogel can compete out, resulting in the collapse of the hydrogel and the release of the electrochemical probe. By detecting the concentration of the released electrochemical probe, the quantitative detection of H2S can be achieved. The prepared hydrogel has a good linear relationship with the concentration of H2S from 1 μM to 60 μm. At the same time, the hydrogel has good specificity and stability, and it can be applied to the detection of H2S in serum samples.

show abstract

Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways

Cited by 40 publications

References 47 publications

Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions

Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions

Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress

One‐Step Synthesis of Chitosan Hydrogel as Electrochemical Chemosensor for Hydrogen Sulfide Detection in Pregnancy‐Induced Hypertension Syndrome Serum Sample

Contact Info

Product

Resources

About