Rapid and ultrasensitive detection of acute kidney injury biomarkers CH3L1 and L-FABP using surface-enhanced Raman spectroscopy

Self-assembly of Au nanocubes for ultrasensitive detection of Alzheimer's disease biomarkers by SERS

“…The linear regression equations are shown in Table 2, with correlation coefficients of 0.990 and 0.991, respectively. The LOD can be calculated in the background signal according to the IUPAC, 26,49 and the LODs of Aβ 1–42 and tau protein were calculated to be 0.041 ng mL −1 and 0.008 ng mL −1 , respectively. In addition, physiological concentrations of tau protein have been reported to be at low picomolar levels in AD patients, 50 and physiological concentrations of Aβ1-42 fibrils in AD patients are at low nanomolar levels.…”

“…The limit of detection (LOD) was defined as three times the value of the value of instrumental background signal generated by the matrix blank signal (S/N = 3), as described in the literature. 26…”

“…Due to these advantages, SERS has been widely used for the qualitative and quantitative detection of trace substances in the eld of biosensing. [24][25][26] For example, Wang et al used GO/Au@Ag core/ shell nanoparticles to detect acute kidney injury biomarkers CH3L1 and L-FABP, 26 and Cui et al used gold-silver bimetallic nanotrepangs to detect cancer-related exosomes. 27 More importantly, SERS can present the characteristic peaks of many substances in a single spectrum.…”