Rapid and Transient Upregulation of <scp>CCL</scp>11 (Eotaxin‐1) in Mouse Ovary During Terminal Stages of Follicular Development

Kuwabara, Yoshimitsu; Katayama, Akira; Igarashi, Tsutomu; Tomiyama, Ryoko; Piao, Hong‐Guang; Kaneko, Ryuji; Abe, Takashi; Mine, Katsuya; Akira, Shigeo; Orimo, Hideo; Takeshita, Toshiyuki

doi:10.1111/j.1600-0897.2011.01100.x

Cited by 6 publications

(3 citation statements)

References 52 publications

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“…eotaxin‐1 mainly engaged in eosinophil and basophil migration 16 . eotaxin‐1/CCR3 axis was transiently upregulated in the ovarian theca‐interstitial layer in response to LH surge during the terminal stages of follicular development 21 . It induced oxidative stress‐related tissue damage by promoting ROS production in a dose‐dependent manner by eosinophil activation 22‐24 .…”

Section: Discussionmentioning

confidence: 99%

Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency

Liu

Zhang

Jie

et al. 2020

American J Rep Immunol

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Section: Discussionmentioning

confidence: 99%

Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency

Liu

Zhang

Jie

et al. 2020

American J Rep Immunol

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“…Little is known about the role of eotaxin in the ovary, although the presence of its ovarian transcripts has been reported in the rat (Wong et al, ). Furthermore, eotaxin has been shown to rise sharply in response to the pre‐ovulatory LH surge in mice (Kuwabara et al, ), where it may be involved in recruiting eosinophils to the peri‐ovulatory follicle in conjunction with other leukocyte subtypes (Aust et al, ). Eosinophils convert prostaglandins and leukotrienes into eicosanoids which are mediators that determine the site of ovulation (Bili et al, ; Mikuni et al, ; Matousek et al, ; Bandeira‐Melo et al, ).…”

Section: Ovulationmentioning

confidence: 99%

Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

Field

Dasgupta

Cummings

et al. 2013

Molecular Reproduction Devel

160

110

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SUMMARYCytokines are key regulators of ovarian physiology, particularly in relation to folliculogenesis and ovulation, where they contribute to creating an environment supporting follicle selection and growth. Their manifold functions include regulating cellular proliferation/differentiation, follicular survival/atresia, and oocyte maturation. Several cytokines, such as TGF-b-superfamily members, are involved at all stages of folliculogenesis while the production of others is stage-dependent. This review draws upon evidence from both human and animal models to highlight the species-specific roles at each milestone of follicular development. Given these pivotal roles and their ease of detection in follicular fluid, cytokines have been considered as attractive biomarkers of oocyte maturational status and of successful assisted reproductive outcome. Despite this, our understanding of cytokines and their interactions remains incomplete, and is still frequently limited to overly simplistic descriptions of their interrelationships. Given our increased appreciation of cytokine activity in complex and highly regulated networks, we put forward the case for using Bayesian modelling approaches to describe their hierarchical relationships in order to predict causal physiological interactions in vivo.Mol. Reprod. Dev. 81: 284À314,

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“…Patients with endometriosis and endometrial cancer generally have an increased expression of PECAM-1. Additionally, elevated PECAM-1 expression has been identified in individuals with fallopian tube cancer and tubal tuberculosis ( 44 ). These findings suggest that PECAM-1 may play a role in the onset and progression of infertility.…”

Section: Discussionmentioning

confidence: 99%

Application and discoveries of metabolomics and proteomics in the study of female infertility

Shi,

Wu,

et al. 2024

Front. Endocrinol.

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IntroductionFemale infertility is defined as the absence of clinical pregnancy after 12 months of regular unprotected sexual intercourse.MethodsThis study employed metabolomics and proteomics approaches to investigate the relationship between metabolites and proteins and female infertility. The study used metabolomics and proteomics data from the UK Biobank to identify metabolites and proteins linked to infertility.ResultsThe results showed that GRAM domain-containing protein 1C and metabolites fibrinogen cleavage peptides ADpSGEGDFXAEGGGVR and 3-Hydroxybutyrate had a positive correlation with infertility, whereas proteins such as Interleukin-3 receptor subunit alpha, Thrombospondin type-1 domain-containing protein 1, Intestinal-type alkaline phosphatase, and platelet and endothelial cell adhesion molecule 1 exhibited a negative correlation. These findings provide new clues and targets for infertility diagnosis and treatment. However, further research is required to validate these results and gain a deeper understanding of the specific roles of these metabolites and proteins in infertility pathogenesis.DiscussionIn conclusion, metabolomics and proteomics techniques have significant application value in the study of infertility, allowing for a better understanding of the biological mechanisms underlying infertility and providing new insights and strategies for its diagnosis and treatment. These research findings provide a crucial biological mechanistic basis for early infertility screening, prevention, and treatment.

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Rapid and Transient Upregulation of CCL11 (Eotaxin‐1) in Mouse Ovary During Terminal Stages of Follicular Development

Abstract: Gonadotropin surge leads to transient CCL11/CCR3 axis upregulation in the ovarian theca-interstitial layer, suggesting that it is involved in periovulatory physiological processes by affecting follicular vessels.

Cited by 6 publications

References 52 publications

Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency

Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency

Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation

Application and discoveries of metabolomics and proteomics in the study of female infertility

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