Rapid and strong de novo donor-specific antibody development in a lung transplant recipient: Short communication/case report

Lobashevsky, Andrew L.; Rosner, Kevin M.; May, John D.; Duncan, Michael; Hage, Chadi A.; Lushin, Erin N; Anderson, Eve; Roe, David

doi:10.1016/j.trim.2016.12.003

Cited by 1 publication

(2 citation statements)

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“…The development of dnDSAs is a significant problem in contemporary solid organ transplantation. In our previous studies, using the HLAMatchmaker algorithm, we showed that the probability of kidney and liver recipients developing antibodies post‐transplantation correlates with the epitope load of MM antigens 25,40,41 . In this retrospective study, we analyzed the formation of dnDSAs in 220 LT recipients.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous studies, using the HLA-Matchmaker algorithm, we showed that the probability of kidney and liver recipients developing antibodies post-transplantation correlates with the epitope load of MM antigens. 25,40,41 In this retrospective study, we analyzed the formation of dnDSAs in 220 LT recipients. The results of these studies indicate that HLAMatchmaker and PIRCHE-II in silico technologies can be equally used to assess the epitope load of mismatched HLAs, and the latter algorithm determines the Freedom from graft failure (%)…”

Section: Discussionmentioning

confidence: 99%

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Formation of donor‐specific antibodies depends on the epitope load of mismatched HLAs in lung transplant recipients: A retrospective single‐center study

Lobashevsky

Niemann²,

Kowinski

et al. 2022

Clinical Transplantation

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The development of donor-specific antibodies (DSA) has a significant impact on graft outcome in solid organ transplantation. Mismatched HLAs are recognized directly and indirectly by the recipient immune system. Both pathways occur in parallel and result in the generation of plasma cells, DSA, cytotoxic and T helper lymphocytes. Here, we present the results of an analysis of the epitope load of mismatched HLAs in a cohort of 220 lung transplant recipients using two in silico algorithms, HLAMatchmaker and PIRCHE-II (Predicted Indirectly ReCognizable HLA Epitopes). De novo DSA (dnDSA) were detected by single antigen bead assays. The percentage of recipients who developed dnDSA was significantly higher in the group of patients who received lung transplants with a mismatching score above the detected threshold than in the group of patients who received lung transplants with a mismatching score below the threshold.In a multivariate Cox proportional hazard analysis, the PIRCHE-II score appeared to be a superior predictor of dnDSA formation. In addition, PIRCHE-II technology was shown to be useful in predicting separate dnDSA1 and dnDSA2 formation. We conclude that both algorithms can be used for the evaluation of the epitope load of mismatched HLAs and the prediction of DSA development in lung transplant recipients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%