Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV

Evans, David T.; Knapp, Leslie A.; Jing, Peicheng; Mitchen, Jacque; Dykhuizen, Marta; Montefiori, David C.; Pauza, C. David; Watkins, David I.

doi:10.1016/s0165-2478(98)00151-5

Cited by 58 publications

(48 citation statements)

References 23 publications

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“…NB2 was included because carriers had a significantly lower viral load; therefore, NB2 may have a protective effect. Mamu-B*17 and Mamu-A*11 were included because the presence of these alleles had distinguished rapid from slow progressors in a previous study (18,42). In this study, the number of Mamu-B*17 carriers was too small to detect a significant effect.…”

Section: Association Of Mhc Class I Alleles With Viral Load and Survimentioning

confidence: 93%

“…Mhc genes and haplotypes associated with disease progression have also been identified in SIV-infected rhesus monkeys (17)(18)(19). Since the virus strains used for most experiments in SIV research are genetically less divers than the different HIV-1 subtypes, one would expect more consistent associations between Mhc alleles and disease progression than in HIV-1-infected humans.…”

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confidence: 99%

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MHC Class I Alleles Influence Set-Point Viral Load and Survival Time in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

Mühl

Krawczak

Haaft

et al. 2002

The Journal of Immunology

146

126

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In HIV-infected humans and SIV-infected rhesus macaques, host genes influence viral containment and hence the duration of the disease-free latency period. Our knowledge of the rhesus monkey immunogenetics, however, is limited. In this study, we describe partial cDNA sequences of five newly discovered rhesus macaque (Mamu) class I alleles and PCR-based typing techniques for the novel and previously published Mhc class I alleles. Using 15 primer pairs for PCR-based typing and DNA sequence analysis, we identified at least 21 Mhc class I alleles in a cohort of 91 SIV-infected macaques. The results confirm the presence of multiple class I genes in rhesus macaques. Of these alleles, Mamu-A*01 was significantly associated with lower set-point viral load and prolonged survival time. Mamu-A*1303 was associated with longer survival and a “novel” Mhc class I allele with lower set-point viral load. The alleles are frequent in rhesus macaques of Indian origin (12–22%). In addition, survival probability of individual SIV-infected rhesus monkeys increased with their number of alleles considered to be associated with longer survival. The results contribute to improve the interpretation and quality of preclinical studies in rhesus monkeys.

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Section: Association Of Mhc Class I Alleles With Viral Load and Survimentioning

confidence: 93%

mentioning

confidence: 99%

MHC Class I Alleles Influence Set-Point Viral Load and Survival Time in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

Mühl

Krawczak

Haaft

et al. 2002

The Journal of Immunology

146

126

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“…One macaque in the anti-FasL group and 2 in the control group were Mamu A01-positive, the first allele ever linked to slow progression. 22 …”

Section: Animals and Treatmentsmentioning

confidence: 99%

Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus

Poonia¹,

Salvato²,

Yagita

et al. 2009

Blood

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Immune deficiency viruses such as SIV in macaques or HIV-1 in human beings have evolved mechanisms to defeat host immunity that also impact the efficacy of vaccines. A key factor for vaccine protection is whether immune responses elicited by prior immunization remain at levels sufficient to limit disease progression once a host is exposed to the pathogen. One potential mechanism for escaping preexisting immunity is to trigger death among antigen-activated cells. We tested

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“…This finding indicates that Mhc class I genotypes have a much more marked influence upon disease progression than class II genotypes, thereby corroborating previous reports on HIV-infected humans 20 and SIV-infected macaques. 38 Mhc region configurations explain at least 48% of the variation in disease progression In order to somehow quantify the overall influence of the Mhc genotype on disease progression in our study cohort, we performed a post hoc unbalanced one-way analysis of variance (ANOVA) of the 60 observed event times (that is, euthanizations with AIDS …”

Section: Contribution Of Mhc Class II Genotypes To Survival Timementioning

confidence: 99%

Mhc class I haplotypes associated with survival time in simian immunodeficiency virus (SIV)-infected rhesus macaques

Sauermann

Siddiqui

et al. 2007

Genes Immun

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In both human immunodeficiency virus-infected humans and simian immunodeficiency virus (SIV)-infected macaques, genes encoded in the major histocompatibility complex (MHC) class I region are important determinants of disease progression. However, compared to the human human lymphocyte antigen complex, the macaque MHC region encodes many more class I genes. Macaques with the same immunodominant class I genes express additional Mhc genes with the potential to influence the disease course. We therefore assessed the association between of the Mhc class I haplotypes, rather than single gene variants, and survival time in SIV-infected rhesus macaques (Macaca mulatta). DNA sequence analysis and Mhc genotyping of 245 pedigreed monkeys identified 17 Mhc class I haplotypes that constitute 10 major genotypes. Among 81 vaccination-naive, SIV-infected macaques, 71 monkeys carried at least one Mhc class I haplotype encoding only MHC antigens that were incapable of inducing an effective anti-SIV cytotoxic T lymphocytes response. Study of these macaques enabled us to relate individual Mhc class I haplotypes to slow, medium and rapid disease progression. In a post hoc analysis, classification according to disease progression was found to explain at least 48% of the observed variation of survival time.

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Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV

Cited by 58 publications

References 23 publications

MHC Class I Alleles Influence Set-Point Viral Load and Survival Time in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

MHC Class I Alleles Influence Set-Point Viral Load and Survival Time in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus

Mhc class I haplotypes associated with survival time in simian immunodeficiency virus (SIV)-infected rhesus macaques

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