Rapid and simultaneous determination of histidine metabolism intermediates in human and mouse microbiota and biomatrices

Acuña, Inmaculada; Ruiz, Alberto Matarán; Cerdó, Tomás; Cantarero, Samuel; López‐Moreno, Ana; Aguilera, Margarita; Campoy, Cristina; Suárez, Antonio

doi:10.1002/biof.1766

Cited by 11 publications

(4 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enrichment of such cellular and genetic processing pathways suggests active cellular activity in Bengali populations. On the other hand, histidine is essential for muscle carnosine synthesis, and its metabolism is associated with physical endurance, recognition memory, neural protection, satiety, and allergic diseases 101,102 . The presence of this metabolic pathway in the Chakma and Marma tribes’ samples indicates that SCFAs play an essential role in the metabolism of their diet ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome Composition Reveals the Distinctiveness between the Bengali people and the Indigenous Ethnicities in Bangladesh

Ahammad¹,

Rahman²,

Chowdhury³

et al. 2023

Preprint

View full text Add to dashboard Cite

Human gut microbiome is influenced by ethnicity and other factors. In this study, we have explored the gut microbiome of Bengali population (n=13) and four Tibeto-Burman indigenous communities- Chakma (n=15), Marma (n=6), Khyang (n=10), and Tripura (n=11) using 16S rRNA amplicon sequencing. A total of 19 characterized phyla were identified in 5 cohorts, with Firmicutes and Bacteroidetes being the most prevalent. At the genus level, the abundance of Prevotella was relatively similar across all ethnicities. However, the Chakma population demonstrated higher Bacteroides abundance. Chakma people were more distinct than other ethnicities and exhibited a higher quantity of differentially abundant microbial features. The Bengali population had relatively low bacterial richness and Firmicutes to Bacteroidetes ratio than others with lower qualitative microbial diversity. A phylosymbiotic link between Bangladeshi indigenous people and certain ethnic groups in India have also been discovered. A comparative analysis between all Bangladeshi samples (n=55) and several tropical and subtropical countries (n=132) such as Australia, Egypt, Indonesia, Malaysia, Mexico, Thailand, and Vietnam revealed that the gut microbiota profile of Bangladeshi people is remarkably distinct from others. The insights from this study will aid further epidemiological and translational research.

show abstract

Section: Discussionmentioning

confidence: 99%

Gut Microbiome Composition Reveals the Distinctiveness between the Bengali people and the Indigenous Ethnicities in Bangladesh

Ahammad¹,

Rahman²,

Chowdhury³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Metabolites that decreased in the human feces and this murine model include N-acetylhistamine and ethylmalonate. N-acetylhistamine is a gut microbial-derived metabolite of histidine metabolism and can act as a stimulant of gastric secretion [ 73 ]. High levels of ethylmalonate observed in the rice bran group mice may indicate improved fatty acid transport associated with rice bran.…”

Section: Discussionmentioning

confidence: 99%

Integrated Microbiota and Metabolite Changes following Rice Bran Intake during Murine Inflammatory Colitis-Associated Colon Cancer and in Colorectal Cancer Survivors

Weber

Ibrahim

Baxter

et al. 2023

Cancers

View full text Add to dashboard Cite

Dietary rice bran-mediated inhibition of colon carcinogenesis was demonstrated previously for carcinogen-induced rodent models via multiple anti-cancer mechanisms. This study investigated the role of dietary rice bran-mediated changes to fecal microbiota and metabolites over the time course of colon carcinogenesis and compared murine fecal metabolites to human stool metabolic profiles following rice bran consumption by colorectal cancer survivors (NCT01929122). Forty adult male BALB/c mice were subjected to azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated colon carcinogenesis and randomized to control AIN93M (n = 20) or diets containing 10% w/w heat-stabilized rice bran (n = 20). Feces were serially collected for 16S rRNA amplicon sequencing and non-targeted metabolomics. Fecal microbiota richness and diversity was increased in mice and humans with dietary rice bran treatment. Key drivers of differential bacterial abundances from rice bran intake in mice included Akkermansia, Lactococcus, Lachnospiraceae, and Eubacterium xylanophilum. Murine fecal metabolomics revealed 592 biochemical identities with notable changes to fatty acids, phenolics, and vitamins. Monoacylglycerols, dihydroferulate, 2-hydroxyhippurate (salicylurate), ferulic acid 4-sulfate, and vitamin B6 and E isomers significantly differed between rice bran- and control-fed mice. The kinetics of murine metabolic changes by the host and gut microbiome following rice bran consumption complemented changes observed in humans for apigenin, N-acetylhistamine, and ethylmalonate in feces. Increased enterolactone abundance is a novel diet-driven microbial metabolite fecal biomarker following rice bran consumption in mice and humans from this study. Dietary rice bran bioactivity via gut microbiome metabolism in mice and humans contributes to protection against colorectal cancer. The findings from this study provide compelling support for rice bran in clinical and public health guidelines for colorectal cancer prevention and control.

show abstract

“…Histidine (His) is a nutritionally essential amino acid and plays a unique role in many physiological processes. His metabolism is a key physiologically pathway involved in the skin, recognition memory, neural protection, and allergic and kidney diseases. , The metabolites, such as histamine (Hi), imidazole-4-acetate (IMA), N -acetylhistamine ( N -acetylHi), and imidazole propionate (IMP), are all strong physiological active substances and possible neurotransmitters. Abnormal levels of His and these metabolites may be at risk for many diseases .…”

Section: Introductionmentioning

confidence: 99%

Photoluminescence–Electrochemiluminescence Dual-Mode Sensor Arrays for Histidine and Its Metabolite Discrimination and Disease Identification

Qian,

Liu,

Huo

et al. 2023

Anal. Chem.

View full text Add to dashboard Cite

Histidine (His) and its metabolite analysis is significant due to their vital roles in the diagnosis of diseases. In practical applications, simple and effective detection and discrimination of these metabolic species are still a great challenge due to their highly similar structures. Herein, photoluminescence (PL)−electrochemiluminescence (ECL) dual-mode sensor arrays consisting of a series of sensing elements were proposed for simultaneous quantitation and accurate discrimination of His and its four key metabolites (including histamine, imidazole-4-acetic acid, N-acetylhistamine, and imidazole propionate). The sensing elements of these sensor arrays were constructed by employing two solvent iridium(III) complexes ([Ir(pbz) 2 (DMSO)Cl] and [Ir-(ppy) 2 (DMSO)Cl], pbz = 3-(2-pyridyl)benzoic acid, ppy = 2phenylpyridine) with excellent PL and ECL performances as cross-responsive sensing units. Based on diverse coordination abilities of the two complexes with the imidazole group of the five targets, PL and ECL responses of each sensing unit can be enhanced to various degrees, which generate unique fingerprint patterns for the corresponding targets. Through principal component analysis, the multifarious patterns (two-, three-, and four-element sensor arrays) can be transformed into simple visualization modes, from which His and its four key metabolites can be effectively discriminated against each other. Moreover, the quantitation of an individual metabolic species at different concentrations and the recognition of the mixtures with different ratios were also accurately achieved. Notably, His and its four key metabolites in urine can also be successfully discriminated by the as-fabricated sensor arrays, and the patients with kidney diseases can be identified clearly, providing a promising way for disease diagnosis.

show abstract

Rapid and simultaneous determination of histidine metabolism intermediates in human and mouse microbiota and biomatrices

Cited by 11 publications

References 49 publications

Gut Microbiome Composition Reveals the Distinctiveness between the Bengali people and the Indigenous Ethnicities in Bangladesh

Gut Microbiome Composition Reveals the Distinctiveness between the Bengali people and the Indigenous Ethnicities in Bangladesh

Integrated Microbiota and Metabolite Changes following Rice Bran Intake during Murine Inflammatory Colitis-Associated Colon Cancer and in Colorectal Cancer Survivors

Photoluminescence–Electrochemiluminescence Dual-Mode Sensor Arrays for Histidine and Its Metabolite Discrimination and Disease Identification

Contact Info

Product

Resources

About